A small molecule--DNA binding landscape.

abstract：:We describe the synthesis of several polyamides that retain the secondary structure of proteins and contain derivatizable side chains. The derivatizable side chain allows for further reaction of the polymer chain (e.g., chain cross-linking or addition of pendant groups). Polymers of alpha-amino acids containing a term...

journal_title：Biopolymers

authors： Guinn RM,Margot AO,Taylor JR,Schumacher M,Clark DS,Blanch HW

更新日期：1995-05-01 00:00:00

abstract：:Aromatic stacking and hydrogen bonding between nucleobases are two of the key interactions responsible for stabilization of DNA double-helical structures. The present work aims at defining the specific contributions of these interactions to the stability of individual base pairs in DNA. The two DNA double helices inve...

journal_title：Biopolymers

authors： Every AE,Russu IM

更新日期：2007-10-05 00:00:00

abstract：:The structure of starch was studied using small-angle x-ray scattering (SAXS). The scattering data was modeled by considering a finite stack of alternating lamellae that are allowed to fluctuate both along the layer repeat direction and along the transverse layer direction. Analysis in this way of the SAXS data from s...

journal_title：Biopolymers

authors： Daniels DR,Donald AM

更新日期：2003-06-01 00:00:00

abstract：:Elucidation of mechanisms underlying collagen fibril assembly and matrix-induced guidance of cell fate will contribute to the design and expanded use of this biopolymer for research and clinical applications. Here, we define how Type I collagen oligomers affect in-vitro polymerization kinetics as well as fibril micros...

journal_title：Biopolymers

authors： Bailey JL,Critser PJ,Whittington C,Kuske JL,Yoder MC,Voytik-Harbin SL

更新日期：2011-02-01 00:00:00

abstract：:Physiological properties of soluble antigen-antibody (Ag-Ab) complexes depend in part on the size of the complexes. In previous work, the size distribution and structure of model Ag-Ab complexes were determined by electron microscopy. In this study, we used constrained regularization analysis of quasi-elastic light sc...

journal_title：Biopolymers

authors： Murphy RM,Yarmush ML,Colton CK

更新日期：1991-10-01 00:00:00

abstract：:The DNA-binding protein HU from Bacillus stearothermophilus (HUBst) is a dimer with a molecular weight of 195 kDa that is capable of bending DNA. An x-ray structure has been determined previously [Tanaka et al. 1984) Nature, vol. 310, pp. 376-381], but no structure could be established for a large part of the supposed...

journal_title：Biopolymers

authors： Boelens R,Vis H,Vorgias CE,Wilson KS,Kaptein R

更新日期：1996-01-01 00:00:00

abstract：:The visual pigment rhodopsin has been extensively studied for the kinetics of its photointermediates by various spectroscopic methods. Unlike such archaeal retinal proteins as bacteriorhodopsin, visual rhodopsin does not thermally recover its dark state after photoexcitation, which precludes repeated excitation of a s...

journal_title：Biopolymers

authors： Lüdeke S,Lórenz Fonfría VA,Siebert F,Vogel R

更新日期：2006-10-05 00:00:00

abstract：:Nocistatin, a new heptadecapeptide encoded in the bPNP-3 gene, has a powerful biological activity connected with the mechanisms of pain transmission. It does not bind to the opioid receptors but to another brain receptor with high affinity. In order to substantiate these novel biological data with a structural basis, ...

journal_title：Biopolymers

authors： Crescenzi O,Guerrini R,Picone D,Salvadori S,Tancredi T,Temussi PA

更新日期：2000-03-01 00:00:00

abstract：:We developed dictionaries of two-, three-, and five-residue patterns in proteins and computed the average solvent accessibility of the central residues in their native proteins. These dictionaries serve as a look-up table for making subsequent predictions of solvent accessibility of amino acid residues. We find that p...

journal_title：Biopolymers

authors： Wang JY,Ahmad S,Gromiha MM,Sarai A

更新日期：2004-10-15 00:00:00

abstract：:A novel approach to sequentially degrade peptoid N-terminal N-(substituted)glycine residues on the solid-phase using very mild conditions is reported. This method relies on the treatment of resin-bound, bromoacetylated peptoids with silver perchlorate in THF, leading to an intramolecular cyclization reaction to libera...

journal_title：Biopolymers

authors： Proulx C,Noë F,Yoo S,Connolly MD,Zuckermann RN

更新日期：2016-09-01 00:00:00

abstract：:The degradation of elastin, the insoluble biopolymer of tropoelastin, can lead to the production of small peptides. These elastin-derived peptides (EDPs) are playing a key role in cellular behavior within the extracellular matrix, showing a great variety of biological effects such as chemotaxis, stimulation of cell pr...

journal_title：Biopolymers

authors： Moroy G,Alix AJ,Héry-Huynh S

更新日期：2005-07-01 00:00:00

abstract：:Dynamic and static intensity light scattering techniques were employed to identify conditions allowing preparation of homogeneous solutions of distinct oligomeric states of RecA protein. These hydrodynamically distinguishable oligomer populations of RecA protein were obtained in homogeneous pure quantities sufficient ...

journal_title：Biopolymers

authors： Budzynski DM,Gao X,Benight AS

更新日期：1996-04-01 00:00:00

abstract：:In continuation of our studies on the determination of the structural features of functionalized peptides in solution by combining time-resolved fluorescence data and molecular mechanics results, the conformational features of a series of linear, L-(alphaMe)Val-based peptides have been investigated in methanol. These ...

journal_title：Biopolymers

authors： Pispisa B,Mazzuca C,Palleschi A,Stella L,Venanzi M,Formaggio F,Polese A,Toniolo C

更新日期：2000-01-01 00:00:00

abstract：:Bovine carbonmonoxy hemoglobin investigated with light scattering studies is found to dissociate from its native tetramer structure into dimers and monomers. The values of the hydrated tetramer radius, RT = 32.1 A, and the fractional dissociation vs pH, have been obtained at different ionic strengths from the autocorr...

journal_title：Biopolymers

authors： Lunelli L,Zuliani P,Baldini G

更新日期：1994-06-01 00:00:00

abstract：:The differences in the absorbance in the mid infrared region (Mid IR) between normal and abnormal tissues have been shown to be a possible criterion for the detection of different forms of cancer. The present work aimed to study the effects of cell growth and DNA synthesis on the RNA/DNA ratio, which is a promising pa...

journal_title：Biopolymers

authors： Sahu RK,Mordechai S,Manor E

更新日期：2008-11-01 00:00:00

abstract：:Neurokinins and their receptors are a complex system consisting of at least three endogenous agents--substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)--and their corresponding receptor types, respectively, NK-1, NK-2, and NK-3. Investigations on receptors have been made using sensitive and fairly selective ...

journal_title：Biopolymers

authors： Regoli D,Dion S,Rhaleb NE,Rouissi N,Tousignant C,Jukic D,D'Orleans-Juste P,Drapeau G

更新日期：1989-01-01 00:00:00

abstract：:Small-angle x-ray scattering was used for studying intermediate species, isolated after heat-induced aggregation of the A variant of bovine beta-lactoglobulin. The intermediates were separated in two fractions, the heated metastable dimer and heated metastable oligomers larger than the dimer. The pair distance distrib...

journal_title：Biopolymers

authors： Carrotta R,Arleth L,Pedersen JS,Bauer R

更新日期：2003-10-01 00:00:00

abstract：:Peptides based on 2-amino-2,3-dihydro-1H-cyclopenta[b]anthracene-2-carboxylic acid (antAib), a fluorescent, achiral, alpha-amino acid belonging to the class of C(i) (alpha)-->C(i) (alpha) cyclized, C(alpha,alpha)-disubstituted glycines, combined with L-Ala, up to the hexamer level, were synthesized by solution methods...

journal_title：Biopolymers

authors： Wright K,Lohier JF,Wakselman M,Mazaleyrat JP,Peggion C,Formaggio F,Toniolo C

更新日期：2007-01-01 00:00:00

abstract：:The results are presented for the deconvolution of IR spectra of disaccharides and polysaccharides with alpha and beta configurations of the 1 --> 4 glycosidic linkage (maltose, cellobiose, amylose, and cellulose), as well as of their corresponding monosaccharides (alpha- and beta-D-glucose) in the 1200-920 cm(-1) fre...

journal_title：Biopolymers

authors： Nikonenko NA,Buslov DK,Sushko NI,Zhbankov RG

更新日期：2000-01-01 00:00:00

abstract：:Per-O-methylated β-cyclodextrin (CD) bearing an iodoacetamide group at the 6-position was synthesized to functionalize protein surfaces. Bovine serum albumin (BSA) was quantitatively modified with the CD derivative by the S(N) 2 reaction of iodoacetamide with a cysteine residue (Cys34) on the BSA surface. The resultan...

journal_title：Biopolymers

authors： Kitagishi H,Kashiwa K,Kano K

更新日期：2012-01-01 00:00:00

abstract：:The pulsed-field gel electrophoresis (PFG) is a newly developing technique used in the fractionation of large DNA fragments. Advances in PFG demand a better understanding in the corresponding mechanisms of DNA dynamics in the gel network. Detailed experiments are needed to verify and to extend existing theoretical pre...

journal_title：Biopolymers

authors： Chu B,Wang ZL,Xu RL,Lalande M

更新日期：1990-03-01 00:00:00

abstract：:Side-chain lactam bridges linking amino acid residues that are spaced several residues apart in the linear sequence offer a convenient and flexible method for introducing conformational constraints into a peptide structure. The availability of a variety of selectively cleavable protecting groups for amines and carboxy...

journal_title：Biopolymers

authors： Taylor JW

更新日期：2002-01-01 00:00:00

abstract：:To investigate the mechanism leading to the reduction in tensile strength of permanent waved human hair, the structure of cross-sections at various depths of permanent waved white human hair was directly analyzed without isolating the cuticle and cortex, using Raman spectroscopy. The beta-sheet and/or random coil cont...

journal_title：Biopolymers

authors： Kuzuhara A

更新日期：2007-02-15 00:00:00

abstract：:TACC3 is a centrosomal adaptor protein that plays important roles during mitotic spindle assembly. It interacts with chTOG/XMAP215, which catalyzes the addition of tubulin dimers during microtubule growth. A 3D coiled-coil model for this interaction is available but the structural details are not well described. To ch...

journal_title：Biopolymers

authors： Partida-Hanon A,Treviño MA,Mompeán M,Jiménez MÁ,Bruix M

更新日期：2017-11-01 00:00:00

abstract：:Inhibitor design against viral targets must take into account the peculiar characteristics of viral biology-in particular, the plasticity of their replicative machinery. This includes maturational cleavage of the polyprotein, which is mediated by virally encoded proteases. Designing against a movable target is particu...

journal_title：Biopolymers

authors： Bianchi E,Pessi A

更新日期：2002-01-01 00:00:00

abstract：:The methods used to study the relative reaction rates of 45 different aliphatic and aromatic carboxylic acids when coupled to resin-bound amino acid amides is described. Competition experiments involving the coupling of incoming carboxylic acids to resin-bound amino acid amides were performed. The relative composition...

journal_title：Biopolymers

authors： Acharya AN,Ostresh JM,Houghten RA

更新日期：2002-10-05 00:00:00

abstract：:Synthetic model membrane-interactive peptides--both of natural and designed sequence--have become convenient and systematic tools for determination of how the membrane-spanning segments within integral membrane proteins confer protein structure and biology. Conformational studies on these peptides demonstrate that the...

journal_title：Biopolymers

authors： Deber CM,Li SC

更新日期：1995-01-01 00:00:00

abstract：:The linear viscoelastic and rheological properties of high molecular weight ovine submaxillary mucin (OSM) solution have been investigated in terms of the Newtonian steady-flow viscosity [eta(gamma)], the complex oscillatory viscosity [eta*(omega)], and the storage and loss shear moduli [G'(omega) and G"(omega)]. It w...

journal_title：Biopolymers

authors： Soby LM,Jamieson AM,Blackwell J,Jentoft N

更新日期：1990-08-15 00:00:00

abstract：:Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of JAK proteins that are receptor-associated tyrosine kinases, which play key roles in the phosphorylation and subsequent activation of several transcription factors named STATs. Unlike the other SOCS proteins, SOCS1 and 3 show, in the N-termina...

journal_title：Biopolymers

authors： La Manna S,Lopez-Sanz L,Leone M,Brandi P,Scognamiglio PL,Morelli G,Novellino E,Gomez-Guerrero C,Marasco D

更新日期：2017-11-20 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) in a silver sol assisted by density functional theory (DFT) calculations is shown to be a promising tool in the characterization of platinum complexes and their interaction with nucleic acid bases. This is demonstrated using cisplatin and guanine as a model. The energies and ...

journal_title：Biopolymers

authors： Giese B,McNaughton D

更新日期：2003-01-01 00:00:00