Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1.

abstract：:Purified integral membrane proteins require amphipathic molecules to maintain their solubility in aqueous solutions. These complexes, in turn, are used in studies to characterise the protein structures by a variety of biophysical and structural techniques, including spectroscopy, crystallography, and cryo-electron mic...

journal_title：Biopolymers

authors： Ireland SM,Sula A,Wallace BA

更新日期：2018-08-01 00:00:00

abstract：:IR vibrational CD (VCD) has been observed for the cyclic pentapeptide cyclo-(-Gly-Pro-Gly-D-Ala-Pro-) in solution in CDBr3. The observed VCD spectra do not resemble the VCD features of any of the previously reported peptide secondary structures, such as alpha-helical, "random coil," or sheet structures, and might be d...

journal_title：Biopolymers

authors： Wyssbrod HR,Diem M

更新日期：1992-09-01 00:00:00

abstract：:CD experiments are reported for several coiled-coil species in the tyrosine/disulfide (approximately 250-350-nm) region. Intact noncross-linked tropomyosin (approximately 3 degrees C) shows a negative nonsymmetric band maximal at 280 nm. This spectrum is the sum over six tyrosines/chain, and has conformational signifi...

journal_title：Biopolymers

authors： Holtzer ME,Kumar S,Holtzer A,Crimmins DL

更新日期：1989-09-01 00:00:00

abstract：:Despite the positive results observed in vitro and in vivo, clinical trials with bioactive peptides are generally hampered by their fast degradation in the biological system. Two bioactive peptides, P20 (CSSRTMHHC) and the combined peptide C (CVNHPAFACGYGHTMYYHHYQHHL) have been identified as anticancer therapeutics. C...

journal_title：Biopolymers

authors： Arruda DC,de Oliveira TD,Cursino PHF,Maia VSC,Berzaghi R,Travassos LR,Tada DB

更新日期：2017-09-01 00:00:00

abstract：:The structural evolution of regenerated Bombyx mori silk fibroin during shearing with a Couette cell has been studied in situ by synchrotron radiation small- and wide-angle x-ray scattering techniques. An elongation of fibroin molecules was observed with increasing shear rate, followed by an aggregation phase. The agg...

journal_title：Biopolymers

authors： Rössle M,Panine P,Urban VS,Riekel C

更新日期：2004-07-01 00:00:00

abstract：:Peptides, peptidomimetics, and peptide derivatives that self-assemble into fibrillar gels have received increasing interest as synthetic extracellular matrices for applications in 3D cell culture and regenerative medicine. Recently, several of these fibrillizing molecules have been functionalized with bioactive compon...

journal_title：Biopolymers

authors： Jung JP,Gasiorowski JZ,Collier JH

更新日期：2010-01-01 00:00:00

abstract：:In continuation of our studies on the determination of the structural features of functionalized peptides in solution by combining time-resolved fluorescence data and molecular mechanics results, the conformational features of a series of linear, L-(alphaMe)Val-based peptides have been investigated in methanol. These ...

journal_title：Biopolymers

authors： Pispisa B,Mazzuca C,Palleschi A,Stella L,Venanzi M,Formaggio F,Polese A,Toniolo C

更新日期：2000-01-01 00:00:00

abstract：:A topochemical model to explain the biological activity of dendrotoxin-I (DTX-I), a potent blocker for potassium channels, was developed by searching common spatial arrangements of functionally important residues between DTX-I, alpha-dendrotoxin, dendrotoxin-K, BgK, ShK, and charybdotoxin. The first three are structur...

journal_title：Biopolymers

authors： Katoh E,Nishio H,Inui T,Nishiuchi Y,Kimura T,Sakakibara S,Yamazaki T

更新日期：2000-07-01 00:00:00

abstract：:The solid state conformational analysis of [Tyr4] cyclolinopeptide A has been carried out by x-ray diffraction studies. The crystal structure of the monoclinic form, grown from a dioxane-water mixture [alpha = 9.849 (5) A, b = 20.752 (4) A, c = 16.728 (5) A, beta = 98.83 (3) degrees, space group P21, Z = 2], shows the...

journal_title：Biopolymers

authors： Saviano M,Rossi F,Filizola M,Isernia C,Di Blasio B,Benedetti E,Pedone C,Siemion IZ,Pedyczak A

更新日期：1995-10-01 00:00:00

abstract：:MD simulations have been carried out to understand the dynamical behavior of the DNA substrate of the Thermus aquaticus DNA methyltransferase (M.TaqI) in the methylation process at N6 of adenine. As starting structures, an x-ray structure of M.TaqI in complex with DNA and cofactor analogue (PDB code: 1G 38) and free d...

journal_title：Biopolymers

authors： Wibowo FR,Rauch C,Trieb M,Liedl KR

更新日期：2005-10-15 00:00:00

abstract：:Photon correlation spectroscopy has been used to study the translational (D0) and internal dynamics of monodisperse linear and polydisperse superhelical plasmid-DNAs. Scattering vector dependent correlation functions were measured and analyzed with the inverse Laplace transform CONTIN written by S. Provencher. For sca...

journal_title：Biopolymers

authors： Seils J,Dorfmüller T

更新日期：1991-06-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) plays a central role in the cellular transduction network. In particular, during chronic heart failure GRK2 is upregulated and believed to contribute to disease progression. Thereby, its inhibition offers a potential therapeutic solution to several pathological conditions. In...

journal_title：Biopolymers

authors： Gomez-Monterrey I,Carotenuto A,Cipolletta E,Sala M,Vernieri E,Limatola A,Bertamino A,Musella S,Grieco P,Trimarco B,Novellino E,Iaccarino G,Campiglia P

更新日期：2014-01-01 00:00:00

abstract：:This brief account traces the development of a "competition dialysis" method used to characterize the structural and sequence selectivity of DNA binding compounds. The method was inspired by a simple "differential dialysis" method pioneered by Don Crothers to explore base-selective intercalator binding. Results from c...

journal_title：Biopolymers

authors： Chaires JB

更新日期：2015-09-01 00:00:00

abstract：:The mode coupling diffusion theory is applied to the derivation of local dynamics in proteins in solution. The rotational dynamics of the bonds along the protein sequence are calculated and compared to the experimentally measured nmr (15)N spin-lattice relaxation time T(1), at 36.5, 60.8, and 81.1 MHz of the vnd/NK-2 ...

journal_title：Biopolymers

authors： La Penna G,Fausti S,Perico A,Ferretti JA

更新日期：2000-08-01 00:00:00

abstract：:While end capping in alpha-helices is well understood, the concept of capping a beta-hairpin is a relatively recent development; to date, favorable Coulombic interactions are the only example of sidechains at the termini influencing the overall stability of a beta-hairpin. While cross-strand hydrophobic residues gener...

journal_title：Biopolymers

authors： Eidenschink L,Crabbe E,Andersen NH

更新日期：2009-07-01 00:00:00

abstract：:An examination of x-ray structures of single-cluster [4Fe-4S] proteins in the Protein Data Bank has revealed that all redox proteins and the glutamine 5-phosphoribosyl-l-pyrophosphate amidotransferase from Bacillus subtilis have a topological configuration arbitrarily designated as D, whereas the DNA repair enzyme end...

journal_title：Biopolymers

authors： Liang C,Mislow K

更新日期：1997-10-05 00:00:00

abstract：:In recent years, a revolution has occurred in the basic sciences, which exploits novel single molecule detection and manipulation tools to track and analyze biopolymers in unprecedented detail. A recent Gordon Research Conference style meeting, hosted by the University of Michigan, highlighted current status and futur...

journal_title：Biopolymers

authors： Walter NG,Meiners JC,Meyhofer E,Neubig RR,Sunahara RK,Perkins NC,Steel DG,Swanson JA

更新日期：2007-02-05 00:00:00

abstract：:The Electrostatically Driven Monte Carlo (EDMC) method was applied in a study of a decamer of glycine whose conformational behavior is described by the Empirical Conformational Energy Program for Peptides (ECEPP/2) potential energy model. When free neutral end groups were used, it was found that conformations that wer...

journal_title：Biopolymers

authors： Ripoll DR,Vásquez MJ,Scheraga HA

更新日期：1991-02-15 00:00:00

abstract：:A new triclinic crystal structure form of porcine pancreatic procarboxypeptidase B (PCPB) was obtained at higher resolution than the previously known tetragonal crystal structure. This new crystal polymorph has allowed for a corrected, accurate assignment of residues along the polypeptide chain based on the currently ...

journal_title：Biopolymers

authors： Fernández D,Boix E,Pallarès I,Avilés FX,Vendrell J

更新日期：2010-02-01 00:00:00

abstract：:Cathelicidins are a numerous group of mammalian proteins that carry diverse antimicrobial peptides at the C-terminus of a highly conserved preproregion. These peptides, which become active when released from the proregion, display a remarkable variety of sizes, sequences, and structures, and in fact comprise represent...

journal_title：Biopolymers

authors： Gennaro R,Zanetti M

更新日期：2000-01-01 00:00:00

abstract：:Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 ...

journal_title：Biopolymers

authors： Petrov RV,Mikhailova AA,Fonina LA

更新日期：1997-01-01 00:00:00

abstract：:The advent of kinetically controlled Native Chemical Ligation has permitted more efficient sequential Native Chemical Ligation reactions to take place in one pot where one or more of the peptide fragments contains an N-terminal cysteine residue and a C-terminal thioester. The reactivity of the thioester component can ...

journal_title：Biopolymers

authors： Ackrill T,Anderson DW,Macmillan D

更新日期：2010-01-01 00:00:00

abstract：:Molecular dynamics simulation, with backbone constraints for 20 ps of equilibration and simulation, of a repeating polypeptide segment, Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-Met-(Gln-Pro-Leu )4, constituting residues 112-138 of bovine amelolgenin, a 19.35 kD hydrophobic protein, are discussed. It is ...

journal_title：Biopolymers

authors： Renugopalakrishnan V,Pattabiraman N,Prabhakaran M,Strawich E,Glimcher MJ

更新日期：1989-01-01 00:00:00

abstract：:We suggest, using dynamical simulations of a simple heteropolymer modelling the alpha-carbon sequence in a protein, that generically the folded states of globular proteins correspond to statistically well-defined metastable states. This hypothesis, called the metastability hypothesis, states that there are several fre...

journal_title：Biopolymers

authors： Honeycutt JD,Thirumalai D

更新日期：1992-06-01 00:00:00

abstract：:The de novo design of peptides and proteins has emerged as an approach for investigating protein structure and function. The success relies heavily on the ability to design relatively short peptides that can adopt stable secondary structures. To this end, substitution with α,β-dehydroamino acids, especially α,β-didehy...

journal_title：Biopolymers

authors： Gupta M,Chauhan VS

更新日期：2011-03-01 00:00:00

abstract：:A suite of FORTRAN programs, PREF, is described for calculating preference functions from the data base of known protein structures and for comparing smoothed profiles of sequence-dependent preferences in proteins of unknown structure. Amino acid preferences for a secondary structure are considered as functions of a s...

journal_title：Biopolymers

authors： Juretić D,Lee B,Trinajstić N,Williams RW

更新日期：1993-02-01 00:00:00

abstract：:The use of peptide carriers, termed "cell-penetrating peptides (CPPs)" has attracted much attention due to their potential for cellular delivery of hydrophilic molecules with pharmacological interest, overcoming the membrane barrier. These peptides are able to deliver attached cargos in a nontoxic manner, with the upt...

journal_title：Biopolymers

authors： Henriques ST,Castanho MA,Pattenden LK,Aguilar MI

更新日期：2010-01-01 00:00:00

abstract：:Peptides represent a rich natural source of potential medicines with one notable pharmaceutical limitation being their relatively short duration of action. A particularly good example of this phenomenon is glucagon-like peptide 1 (GLP), a hormone of appreciable interest for the treatment of type II diabetes. In the na...

journal_title：Biopolymers

authors： De A,DiMarchi RD

更新日期：2010-01-01 00:00:00

abstract：:Multiconfiguration thermodynamic integration was used to determine the relative binding strength of tacrine and 6-chlorotacrine by Torpedo californica acetylcholinesterase. 6-Chlorotacrine appears to be bound stronger by 0.7+/-0.4 kcal/mol than unsubstituted tacrine when the active site triad residue His-440 is deprot...

journal_title：Biopolymers

authors： Wlodek ST,Antosiewicz J,McCammon JA,Straatsma TP,Gilson MK,Briggs JM,Humblet C,Sussman JL

更新日期：1996-01-01 00:00:00

abstract：:The role of phosphorylation in stabilizing the N-termini of alpha-helices is examined using computer simulations of model peptides. The models comprise either a phosphorylated or unphosphorylated serine at the helix N-terminus, followed by nine alanines. Monte Carlo/stochastic Dynamics simulations were performed on th...

journal_title：Biopolymers

authors： Smart JL,McCammon JA

更新日期：1999-03-01 00:00:00