An improved model for analyzing the small angle x-ray scattering of starch granules.

abstract：:We have studied by Raman and ir spectroscopy the structure of self-associated polyinosinic acid and polyguanylic acid in aqueous solution. The results are consistent with the formation of a four-stranded complex, which melts cooperatively near 60 degrees C in the case of poly(I) in the presence of K+ ions. The conform...

journal_title：Biopolymers

authors： Simard C,Savoie R

更新日期：1994-01-01 00:00:00

abstract：:The RNA recognition motif (RRM) is one of the most common RNA binding domains. We have investigated the contribution of three highly conserved aromatic amino acids to RNA binding by the N-terminal RRM of the U1A protein. Recently, we synthesized a modified base (A-4CPh) in which a phenyl group is tethered to adenine u...

journal_title：Biopolymers

authors： Zhao Y,Kormos BL,Beveridge DL,Baranger AM

更新日期：2006-03-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) plays a central role in the cellular transduction network. In particular, during chronic heart failure GRK2 is upregulated and believed to contribute to disease progression. Thereby, its inhibition offers a potential therapeutic solution to several pathological conditions. In...

journal_title：Biopolymers

authors： Gomez-Monterrey I,Carotenuto A,Cipolletta E,Sala M,Vernieri E,Limatola A,Bertamino A,Musella S,Grieco P,Trimarco B,Novellino E,Iaccarino G,Campiglia P

更新日期：2014-01-01 00:00:00

abstract：:Fourier transform IR (FTIR) spectroscopy has been successfully applied in recent years to examine the functional and structural properties of the membrane protein rhodopsin, a prototype G protein coupled receptor. Unlike UV-visible spectroscopy, FTIR spectroscopy is structurally sensitive. It may give us both global i...

journal_title：Biopolymers

authors： Vogel R,Siebert F

更新日期：2003-01-01 00:00:00

abstract：:The chemical synthesis and x-ray crystal structure analysis of a model peptide incorporating a conformationally adaptable unsubstituted beta-Ala residue: Boc-beta-Ala-Acc6-OCH3 (C16H28N2O5, molecular weight = 328.41; 1) has been described. The peptide crystallized in the space group P2(1)2(1)2(1) a = 8.537 (3), b = 8....

journal_title：Biopolymers

authors： Thakur AK,Kishore R

更新日期：2000-05-01 00:00:00

abstract：:Inhibitor design against viral targets must take into account the peculiar characteristics of viral biology-in particular, the plasticity of their replicative machinery. This includes maturational cleavage of the polyprotein, which is mediated by virally encoded proteases. Designing against a movable target is particu...

journal_title：Biopolymers

authors： Bianchi E,Pessi A

更新日期：2002-01-01 00:00:00

abstract：:A simple solid-state NMR method was used to study the structure of (13)C- and (15)N-enriched silk from two Australian orb-web spider species, Nephila edulis and Argiope keyserlingi. Carbon-13 and (15)N spectra from alanine- or glycine-labeled oriented dragline silks were acquired with the fiber axis aligned parallel o...

journal_title：Biopolymers

authors： Bonev B,Grieve S,Herberstein ME,Kishore AI,Watts A,Separovic F

更新日期：2006-06-05 00:00:00

abstract：:A large number of potent and selective therapeutic agents, useful for the treatment of several diseases, have been isolated from natural sources. For example, the most active thrombin inhibitors are those secreted by the salivary glands of leeches. One peculiar feature of these agents is the lack of any significant in...

journal_title：Biopolymers

authors： Lombardi A,De Simone G,Galdiero S,Staiano N,Nastri F,Pavone V

更新日期：1999-01-01 00:00:00

abstract：:This report details the observation of (a) the intact double helix of DNA at 0% relative humidity in poly(dA).poly(dT) and poly(dA-dT).poly(dA-dT) films, (b) the fractal-like growth of DNA crystals in films of poly(dA).poly(dT), and (c) poly(dA).poly(dT) with adenines in the B form and thymines in the A form. Observat...

journal_title：Biopolymers

authors： Sclavi B,Peticolas WL,Powell JW

更新日期：1994-08-01 00:00:00

abstract：:Different hexameric forms of insulin have been crystallized from a variety of conditions. In the presence of 1% phenol, 1.0 M sodium chloride, and at a pH of 8.5, a rhombohedral form is produced with two monomers in the asymmetric unit, space group R3, a = 79.92 A and c = 40.39 A. The structure has been solved and ref...

journal_title：Biopolymers

authors： Smith GD,Dodson GG

更新日期：1992-04-01 00:00:00

abstract：:Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) causes analgesia when systemically administered. The lipophilic ibuprofen-conjugated derivative of KTP-NH2 has improved analgesic efficacy. However, fast degradation by peptidases impacts negatively in the pharmacodynamics of these drugs. In this work, selected derivative...

journal_title：Biopolymers

authors： Serrano ID,Ramu VG,Pinto AR,Freire JM,Tavares I,Heras M,Bardaji ER,Castanho MA

更新日期：2015-01-01 00:00:00

abstract：:The aminoacyl-tRNA synthetases are an ancient group of enzymes that catalyze the covalent attachment of an amino acid to its cognate transfer RNA. The question of specificity, that is, how each synthetase selects the correct individual or isoacceptor set of tRNAs for each amino acid, has been referred to as the second...

journal_title：Biopolymers

authors： Beuning PJ,Musier-Forsyth K

更新日期：1999-01-01 00:00:00

abstract：:The comprehensive understanding of disassembly mechanism of amyloid fibrils requires nano-scale characterization of the mechanical properties of amyloid fibrils during the disassembly process. In this work, gemini surfactant C12 C6 C12 Br2 micelles were used as a probe to disassemble Aβ(1-40) fibrils. The microstructu...

journal_title：Biopolymers

authors： Wang W,Guo Z,Sun J,Li Z

更新日期：2017-02-01 00:00:00

abstract：:An electron paramagnetic resonance (EPR) study was performed for potato and wheat starch containing Cu2+ ions as a paramagnetic probe. Distribution of water in the starch granules as well as the interactions between the copper and starch matrix of different crystalline structures were determined. EPR spectra of the na...

journal_title：Biopolymers

authors： Łabanowska M,Bidzińska E,Dyrek K,Szymońska J

更新日期：2006-08-15 00:00:00

abstract：:The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease-targeted drug delivery approach. Smart nano...

journal_title：Biopolymers

authors： Bertoni S,Machness A,Tiboni M,Bártolo R,Santos HA

更新日期：2020-01-01 00:00:00

abstract：:The conformation of basic fatty acid binding protein from chicken liver and the binding properties of the apo protein toward 11-dansylamino-undecanoic acid were investigated by CD and fluorescence spectroscopy. In one set of experiments the binding process was followed by the appearance of induced optical activity in ...

journal_title：Biopolymers

authors： Schievano E,Quarzago D,Spadon P,Monaco HL,Zanotti G,Peggion E

更新日期：1994-07-01 00:00:00

abstract：:The pressure-induced structural changes of a de novo designed four-helix bundle protein, (alpha-l-alpha)(2), in aqueous solution have been investigated by FTIR spectroscopy. Changes in the amide I' band intensity show that pressure induces disruption of tertiary interactions and stabilizes the solvated alpha-helical f...

journal_title：Biopolymers

authors： Takekiyo T,Takeda N,Isogai Y,Kato M,Taniguchi Y

更新日期：2007-02-05 00:00:00

abstract：:Although the structural analysis of membrane proteins is advancing, an understanding of the basic principles that underlie their folding and assembly remains limited because of the high insolubility intrinsic to these molecules and concomitant challenges in obtaining crystals. Fortunately, from an experimental standpo...

journal_title：Biopolymers

authors： Rath A,Johnson RM,Deber CM

更新日期：2007-01-01 00:00:00

abstract：:A series of novel nonpeptide inhibitors of the pp60(c-Src) (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x-ray structure of citrate complexed to the pTyr binding site of the Src SH2 domain, these nonpeptide ligands i...

journal_title：Biopolymers

authors： Sundaramoorthi R,Kawahata N,Yang MG,Shakespeare WC,Metcalf CA 3rd,Wang Y,Merry T,Eyermann CJ,Bohacek RS,Narula S,Dalgarno DC,Sawyer TK

更新日期：2003-01-01 00:00:00

abstract：:The discovery of the prototype delta opioid antagonists TIPP (H-Tyr-Tic-Phe-Phe-OH) and TIP (H-Tyr-Tic-Phe-OH) in 1992 was followed by extensive structure-activity relationship studies, leading to the development of analogues that are of interest as pharmacological tools or as potential therapeutic agents. Stable TIPP...

journal_title：Biopolymers

authors： Schiller PW,Weltrowska G,Berezowska I,Nguyen TM,Wilkes BC,Lemieux C,Chung NN

更新日期：1999-01-01 00:00:00

abstract：:Human hair as alpha-keratin fiber exhibits a complex morphology, which for the context of this investigation is considered as a filament/matrix-composite, comprising the intermediate filaments (IF) and a variety of amorphous protein components as matrix. Differential scanning calorimetry (DSC) under aqueous conditions...

journal_title：Biopolymers

authors： Wortmann FJ,Popescu C,Sendelbach G

更新日期：2006-12-15 00:00:00

abstract：:The structural evolution of regenerated Bombyx mori silk fibroin during shearing with a Couette cell has been studied in situ by synchrotron radiation small- and wide-angle x-ray scattering techniques. An elongation of fibroin molecules was observed with increasing shear rate, followed by an aggregation phase. The agg...

journal_title：Biopolymers

authors： Rössle M,Panine P,Urban VS,Riekel C

更新日期：2004-07-01 00:00:00

abstract：:The methods used to study the relative reaction rates of 45 different aliphatic and aromatic carboxylic acids when coupled to resin-bound amino acid amides is described. Competition experiments involving the coupling of incoming carboxylic acids to resin-bound amino acid amides were performed. The relative composition...

journal_title：Biopolymers

authors： Acharya AN,Ostresh JM,Houghten RA

更新日期：2002-10-05 00:00:00

abstract：:Many studies have examined consensus sequences required for protein-glycosaminoglycan interactions. Through the synthesis of helical heparin binding peptides, this study probes the relationship between spatial arrangement of positive charge and heparin binding affinity. Peptides with a linear distribution of positive ...

journal_title：Biopolymers

authors： Rullo A,Nitz M

更新日期：2010-03-01 00:00:00

abstract：:Ribonuclease A is the archetype of a functionally diverse superfamily of vertebrate-specific ribonucleases. Inhibitors of its action have potential use in the elucidation of the in vivo roles of these enzymes and in the treatment of pathologies associated therewith. Derivatives of adenosine 5'-pyrophosphate are the mo...

journal_title：Biopolymers

authors： Holloway DE,Chavali GB,Leonidas DD,Baker MD,Acharya KR

更新日期：2009-12-01 00:00:00

abstract：:Surfactant protein C (SP-C) is an important constituent of lung surfactant (LS) and, along with SP-B, is included in exogenous surfactant replacement therapies for treating respiratory distress syndrome (RDS). SP-C's biophysical activity depends upon the presence of a rigid C-terminal helix, of which the secondary str...

journal_title：Biopolymers

authors： Brown NJ,Lin JS,Barron AE

更新日期：2019-06-01 00:00:00

abstract：:Alpha-synuclein (alpha-Syn) has been identified as a component of intracellular fibrillar deposits in Parkinson's disease. Though the real pathogenesis is still unknown, many investigations have revealed that conformational alteration and fibril formation of alpha-Syn protein have an important role in causing the dise...

journal_title：Biopolymers

authors： Lin XJ,Zhang F,Xie YY,Bao WJ,He JH,Hu HY

更新日期：2006-10-15 00:00:00

abstract：:The IR data for the R1 CO-O-CHR2 -CO-NHR3 derivatives are interpreted in terms of a H…π interaction involving the NH bond and the π orbitals of the ester function and giving rise to a high ν(CO) frequency and a low ν frequency. The resulting molecular conformation corresponds to the angular values ϕ # -90°, ψ # 0°. ...

journal_title：Biopolymers

authors： Boussard G,Marraud M

更新日期：1981-01-01 00:00:00

abstract：:Aromatic stacking and hydrogen bonding between nucleobases are two of the key interactions responsible for stabilization of DNA double-helical structures. The present work aims at defining the specific contributions of these interactions to the stability of individual base pairs in DNA. The two DNA double helices inve...

journal_title：Biopolymers

authors： Every AE,Russu IM

更新日期：2007-10-05 00:00:00

abstract：:The (GA)(n) microsatellite has been known from previous studies to adopt unusual, ordered, cooperatively melting secondary structures in neutral aqueous solutions containing physiological concentrations of salts, at acid pH values or in aqueous ethanol solutions. To find more about the primary structure specificity of...

journal_title：Biopolymers

authors： Kypr J,Kejnovská I,Vorlícková M

更新日期：2007-11-01 00:00:00