Abstract:
:Cathelicidins are a numerous group of mammalian proteins that carry diverse antimicrobial peptides at the C-terminus of a highly conserved preproregion. These peptides, which become active when released from the proregion, display a remarkable variety of sizes, sequences, and structures, and in fact comprise representatives of all the structural groups in which the known antimicrobial peptides have been classified. Most of the cathelicidin-derived peptides exert a broad spectrum and potent antimicrobial activity and also bind to lipopolysaccharide and neutralize its effects. In addition, some of them have recently been shown to exert other activities and might participate in host defense also by virtue of their ability to induce expression of molecules involved in a variety of biological processes. This review is aimed at providing a general overview of the cathelicidins and of the peptides derived therefrom, with emphasis on aspects such as structure, biological activities in vitro and in vivo, and structure/activity relationship studies.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Gennaro R,Zanetti Mdoi
10.1002/1097-0282(2000)55:1<31::AID-BIP40>3.0.CO;2subject
Has Abstractpub_date
2000-01-01 00:00:00pages
31-49issue
1eissn
0006-3525issn
1097-0282pii
10.1002/1097-0282(2000)55:1<31::AID-BIP40>3.0.CO;2journal_volume
55pub_type
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