Abstract:
:Vibrational spectroscopy coupled with thermogravimetry (TG) and differential scanning calorimetry (DSC) was used to characterize racemic propanoic acid, 2-methyl-5,6,7,8-tetrahydro-6-(methylamino)-1,2-naphthalenediyl ester hydrochloride (CHF-1035), which is a new DA2 dopaminergic receptor/alpha2 agonist and beta blocker under clinical investigation for the treatment of congestive heart failure. Raman spectroscopy disclosed at least two different CHF-1035 polymorphs; the marker bands characteristic of each form were identified. The modifications undergone by the CHF-1035 drug as a consequence of grinding and heating were investigated. Mechanical and gentle thermal treatments caused a polymorphic transformation of the drug crystal form. Raman spectroscopy proved suitable for investigating the possible presence of different polymorphic forms, their relative stability, and interconversion tendency in relation to industrial manufacturing processes undergone by the drug (i.e., grinding, compression, and heating).
journal_name
Biopolymersjournal_title
Biopolymersauthors
Taddei P,Torreggiani A,Fini Gdoi
10.1002/bip.10089subject
Has Abstractpub_date
2002-01-01 00:00:00pages
289-93issue
4-5eissn
0006-3525issn
1097-0282journal_volume
67pub_type
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