Abstract:
:The solid state conformational analysis of [Tyr4] cyclolinopeptide A has been carried out by x-ray diffraction studies. The crystal structure of the monoclinic form, grown from a dioxane-water mixture [alpha = 9.849 (5) A, b = 20.752 (4) A, c = 16.728 (5) A, beta = 98.83 (3) degrees, space group P21, Z = 2], shows the presence of five intramolecular N-H...O = C hydrogen bonds, with formation of one C17 ring structure, one alpha-turn (C13), one inverse gamma-turn (C7), and two beta-turns (C10, one of type III and one of type I). The Pro1-Pro2 peptide unit is cis (omega = 5 degrees), all others are trans. The structure is almost superimposable with that of cyclolinopeptide A. The rms deviation for the atoms of the backbones is on the average 0.33 A.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Saviano M,Rossi F,Filizola M,Isernia C,Di Blasio B,Benedetti E,Pedone C,Siemion IZ,Pedyczak Adoi
10.1002/bip.360360408subject
Has Abstractpub_date
1995-10-01 00:00:00pages
453-60issue
4eissn
0006-3525issn
1097-0282journal_volume
36pub_type
杂志文章相关文献
BIOPOLYMERS文献大全abstract::Among the most exciting functional features of G-protein coupled receptors (GPCRs) that are coming into focus lately are those relating to the role and structural characteristics of their oligomerization (mostly homo- and heterodimers). The structural underpinnings of these novel functional insights are still not clea...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.10311
更新日期:2002-01-01 00:00:00
abstract::Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all eukaryotes studied to date. In humans, more than 600 ligases are involved in the reversible modification of specific lysine side-chain amines in substrate proteins by conjugation with the C-terminal carboxylate of Ub. Initially monoub...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22253
更新日期:2014-02-01 00:00:00
abstract::In the present paper we describe the synthesis, purification, and single crystal x-ray analysis of the cyclic pentapeptide cyclo-(Pro-Phe-Phe-beta-Ala-beta-Ala). This compound crystallizes in the orthorhombic space group P2I2I2I from methanol and adopts in the solid state an unusual conformation characterized by a cis...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360380602
更新日期:1996-06-01 00:00:00
abstract::The thermal conformational transitions of two sonicated samples of schizophyllan were studied in water-dimethylsulfoxide (DMSO) mixtures by high-sensitivity differential scanning calorimetry (DSC). Two transitions were observed over most of the range of solvent compositions. These were assigned to an internal change o...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360280208
更新日期:1989-02-01 00:00:00
abstract::Many studies have examined consensus sequences required for protein-glycosaminoglycan interactions. Through the synthesis of helical heparin binding peptides, this study probes the relationship between spatial arrangement of positive charge and heparin binding affinity. Peptides with a linear distribution of positive ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21339
更新日期:2010-03-01 00:00:00
abstract::Although several models have been proposed for the interaction of collagen with gelatinase-A (matrix metalloproteinases-2 (MMP-2)), the extensive role of each domain of gelatinase A in hydrolyzing the collagens with and without interruptions is still elusive. Molecular docking, molecular dynamics (MD) simulation, norm...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22457
更新日期:2014-07-01 00:00:00
abstract::We suggest, using dynamical simulations of a simple heteropolymer modelling the alpha-carbon sequence in a protein, that generically the folded states of globular proteins correspond to statistically well-defined metastable states. This hypothesis, called the metastability hypothesis, states that there are several fre...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360320610
更新日期:1992-06-01 00:00:00
abstract::The use of alpha,alpha-disubstituted amino acids represents a valuable strategy to exercise conformational control in peptides. Incorporation of the nonstereogenic alpha-aminoisobutyryl-glycyl (Aib-Gly) dipeptidyl sequence into i+1 and i+2 positions of an acyclic peptide sequence, originally designed and investigated ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20738
更新日期:2007-01-01 00:00:00
abstract::A systematic molecular dynamics (MD) simulation has been carried out on collagen-like peptides with different combinations of interruptions in the Gly-X(AA) -Y(AA) repeats. Although experimental studies have been carried out to elucidate the structural consequences of homotrimeric collagen-like peptides, this is the f...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22085
更新日期:2012-11-01 00:00:00
abstract::Caspases comprise a family of dimeric cysteine proteases that control apoptotic programmed cell death and are therefore critical in both organismal development and disease. Specific inhibition of individual caspases has been repeatedly attempted, but has not yet been attained. Caspase-9 is an upstream or initiator cas...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22080
更新日期:2012-01-01 00:00:00
abstract::We have found that tri-L-alanine (Ala3) can crystallize in a parallel-chain beta structure in addition to the previously known antiparallel-chain beta structure. Although the chain conformations in each structure are essentially similar, the ir and Raman spectra are distinctively different. We have calculated the norm...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360310208
更新日期:1991-02-05 00:00:00
abstract::Insect neuropeptides of the insect kinin class share a common C-terminal pentapeptide sequence F(1)X(1)(2)X(2)(3)W(4)G(5)-NH(2) (X(2)(3) = P, S, A) and regulate such critical physiological processes as water balance and digestive enzyme release. Analogs of the insect kinin class, in which the critical residues of F(1)...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20638
更新日期:2007-01-01 00:00:00
abstract::A natural rubber was identified and characterized for the first time in the latex of the perennial Mediterranean shrub Euphorbia characias. Four different methods, i.e., acetone, acetic acid, trichloroacetic acid, and Triton® X-100, followed by successive treatments with cyclohexane/ethanol, were employed to extract t...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22044
更新日期:2012-08-01 00:00:00
abstract::The conformational heterogeneity of several quinoxaline antibiotics, a class of naturally occurring quinoxaline peptides with antitumor properties, and their synthetic analogues was investigated in polar and nonpolar solvents by high performance liquid chromatography (HPLC) with uv photodiode array detection, uv-absor...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360311404
更新日期:1991-12-01 00:00:00
abstract::The de novo design of peptides and proteins has emerged as an approach for investigating protein structure and function. The success relies heavily on the ability to design relatively short peptides that can adopt stable secondary structures. To this end, substitution with α,β-dehydroamino acids, especially α,β-didehy...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.21561
更新日期:2011-03-01 00:00:00
abstract::The formation mechanism of an alanine-based peptide has been studied by all-atom molecular dynamics simulations with a recently developed all-atom point-charge force field and the Generalize Born continuum solvent model at an effective salt concentration of 0.2M. Thirty-two simulations were conducted. Each simulation ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.10216
更新日期:2003-01-01 00:00:00
abstract::Differential scanning calorimetry measurements performed on RNase A in aqueous binary solutions containing different concentrations of urea, tetramethylurea, guanidinium chloride, and guanidinium thiocyanate, and in aqueous ternary solutions, containing the same denaturants plus 1 M trimethylamine N-oxide, TMAO, demon...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23104
更新日期:2018-08-01 00:00:00
abstract::Elastin-like polypeptide (ELP) fusions have been designed to allow large-scale, nonchromatographic purification of many soluble proteins by using the inverse transition cycling (ITC) method; however, the sensitivity of the aqueous lower critical solubility phase transition temperature (T(t)) of ELPs to the addition of...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22137
更新日期:2013-01-01 00:00:00
abstract::The sweet protein brazzein isolated from the fruit of the African plant, Pentadiplandra brazzeana Baillon is 2000-500 times sweeter than sucrose and consists of 54 amino acid residues with four intramolecular disulfide bonds. Brazzein was prepared by the fluoren-9-yl-methoxycarbonyl solid-phase method, and was identic...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(sici)1097-0282(199607)39:1<95::aid-bip10>
更新日期:1996-07-01 00:00:00
abstract::Individual ethidium-stained DNA molecules, embedded in an agarose gel made with electrophoresis buffer (0.05 molar salt), are observed using a fluorescence microscope. In the first experiment, open circular 66 kilobase pair (kbp) plasmids, immobilized by agarose fibers threaded through their centers, display entropic ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360290807
更新日期:1990-07-01 00:00:00
abstract::Bombolitins are five structurally related heptadecapeptides originally isolated from the venom of a bumblebee, acting at membrane level and able to enhance the activity of Phospholipase A2. The biological activity of this class of natural peptides seems to be related to the their ability to form amphiphilic helical st...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0282(1997)43:6<419::AID-BIP4>3.
更新日期:1997-01-01 00:00:00
abstract::A highly potent and selective agonist to the tachykinin NK-3 receptor, [pGlu6,N-MePhe8,Aib9] substance P (6-11) (I), was synthesized via the solid phase method. The ED50 of I was 4 nM in the guinea pig ileum in the absence of atropine (NK-1+NK-3 receptors) and this agonist was 5000-fold less potent in the presence of ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360330607
更新日期:1993-06-01 00:00:00
abstract::Although the structural analysis of membrane proteins is advancing, an understanding of the basic principles that underlie their folding and assembly remains limited because of the high insolubility intrinsic to these molecules and concomitant challenges in obtaining crystals. Fortunately, from an experimental standpo...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20668
更新日期:2007-01-01 00:00:00
abstract::Small multidisulfide-containing proteins are attractive structural templates to produce a biologically active conformation that mimics the binding surface of natural large proteins. In particular, the structural motif that is evolutionary conserved in all scorpion toxins has a small size (30-40 amino acid residues), a...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0282(1998)47:1<93::AID-BIP10>3.
更新日期:1998-01-01 00:00:00
abstract::A winter flounder antifreeze polypeptide (HPLC-6) has been studied in vacuo and in aqueous solution using molecular dynamics computer simulation techniques. The helical conformation of this polypeptide was found to be stable both in vacuum and in solution. The major stabilizing interactions were found to be the main-c...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360331002
更新日期:1993-10-01 00:00:00
abstract::A novel approach to sequentially degrade peptoid N-terminal N-(substituted)glycine residues on the solid-phase using very mild conditions is reported. This method relies on the treatment of resin-bound, bromoacetylated peptoids with silver perchlorate in THF, leading to an intramolecular cyclization reaction to libera...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22884
更新日期:2016-09-01 00:00:00
abstract::The HPLC retention behavior of three complete single methionine and methionine sulfoxide replacement sets of two 18-mer model peptides and neuropeptide Y (NPY) were investigated. All peptides were prepared by multiple solid-phase peptide synthesis. Plotting the retention time differences between methionine and methion...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0282(199608)39:2%3C207::AID-BIP
更新日期:1996-08-01 00:00:00
abstract::Decomposition of CD spectra for the unfolding of both coiled-coil and single-helical molecules is carried out via the convex constraint algorithm (CCA) [A. Perczel, M. Hollósi, G. Tusnády, and G. D. Fasman (1991) Protein Engineering, Vol. 4, pp. 669-679]. Examined are (1) our thermal unfolding data for rabbit alpha al...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360360310
更新日期:1995-09-01 00:00:00
abstract::Four members of the carcinoembryonic antigen family, CEACAMs 1, 3, 6, and 8, are expressed on human neutrophils and can trigger an activation signal that increases neutrophil adhesion to human umbilical vein endothelial cell (HUVEC) monolayers. To identify active sites on CEACAM1, we previously performed molecular mod...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21447
更新日期:2011-01-01 00:00:00
abstract::Piscidin 1 (Pis-1) has a high broad-spectrum activity against bacteria, fungi, and viruses but it also has a moderate hemolytic activities. To improve the antibacterial activity and to reduce toxicity, mutants Pis-1AA (G8A/G13A double mutant) and Pis-1PG (G8P mutant) have been designed based on the crystal structure o...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22116
更新日期:2012-12-01 00:00:00