Abstract:
:The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Yague-Sanz C,Vázquez E,Sánchez M,Antequera F,Hermand Ddoi
10.1007/s00294-016-0642-ysubject
Has Abstractpub_date
2017-05-01 00:00:00pages
187-193issue
2eissn
0172-8083issn
1432-0983pii
10.1007/s00294-016-0642-yjournal_volume
63pub_type
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