A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions.

Abstract:

:The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.

journal_name

Curr Genet

journal_title

Current genetics

authors

Yague-Sanz C,Vázquez E,Sánchez M,Antequera F,Hermand D

doi

10.1007/s00294-016-0642-y

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

187-193

issue

2

eissn

0172-8083

issn

1432-0983

pii

10.1007/s00294-016-0642-y

journal_volume

63

pub_type

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