HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

Abstract:

:The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.

journal_name

Curr Genet

journal_title

Current genetics

authors

Sánchez-Díaz A,Blanco MA,Jones N,Moreno S

doi

10.1007/s002940100241

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

110-8

issue

2

eissn

0172-8083

issn

1432-0983

journal_volume

40

pub_type

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