Abstract：
:Efficient mating-type (MT) switching in homothallic strains of Schizosaccharomyces pombe is significantly reduced if they have a mutation in any of the eleven known swi genes. The swi4 mutation causes heterothallic as well as homothallic segregants, both of which have duplications in the MT region. In contrast to homothallic strains, h+ swi4 strains yield only a few duplications. The duplications originate in the process of MT switching, presumably by mistakes in the resolution of DNA intermediates. They always consist of one cassette and one of the intervening sequences, L and K respectively. Strains with up to seven cassettes in the MT region were found. The possible modes of their origins are discussed.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Fleck O,Heim L,Gutz Hdoi
10.1007/BF00327020subject
Has Abstractpub_date
1990-12-01 00:00:00pages
501-9issue
6eissn
0172-8083issn
1432-0983journal_volume
18pub_type
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