Abstract：
BACKGROUND:The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades. AIMS:To clarify the relationship between cumulative MS factors and symptomatic KOA. METHODS:A cross-sectional survey involving 119 women aged 45-88 years who were scheduled to undergo knee surgery was conducted. They were stratified into tertiles of symptoms as assessed by the Japanese Orthopedic Association score for KOA. Multinomial logistic regressions were performed using the severity of symptomatic KOA as the dependent variable and each MS factor or the cumulative MS factors as the independent variables. RESULTS:Logistic regression analyses were performed with the upper tertile of stratified symptoms of subjects used as the reference group. After adjustment for confounders, KOA patients who had two (p = 0.004) or three or more (p < 0.0001) MS factors were significantly more likely to have severe symptoms compared to those who had no MS factors. MS factors excluding obesity were similarly analyzed. Even after additional adjustment for body mass index (BMI), KOA patients who had two or more (p = 0.005) MS factors were significantly more likely to have severe symptoms. CONCLUSION:Among KOA female patients diagnosed using radiographic definition, the severity of symptomatic KOA was significantly associated with hypertension, dyslipidemia, and the number of MS factors after adjustment for age, BMI, strength of the knee extensor, and Kellgren-Lawrence grade. The severity of radiographic KOA was not associated with any MS factor or cumulative MS factors.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Yasuda E,Nakamura R,Matsugi R,Goto S,Ikenaga Y,Kuroda K,Nakamura S,Katsuki Y,Katsuki Tdoi
10.1007/s40520-017-0808-6subject
Has Abstractpub_date
2018-05-01 00:00:00pages
481-488issue
5eissn
1594-0667issn
1720-8319pii
10.1007/s40520-017-0808-6journal_volume
30pub_type
杂志文章abstract：BACKGROUND AND AIMS:Squamous cell carcinoma (SCC) of the oral tongue is one of the most frequent head and neck cancers. The over-70-year age group is the fastest growing segment of the population. Age, however, is not considered a prognostic factor in oral tongue SCC. This study investigated the clinical and histopatho...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324964
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring f...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0377-5
更新日期：2016-10-01 00:00:00
abstract：:Mood disorders are common and often under-recognised in older people whereby, together with the general ageing of the population, they are becoming a significant and growing public health problem worldwide. However, the need to address the problem of late life mood disorders in a real-world setting is met with a surpr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0149-z
更新日期：2014-04-01 00:00:00
abstract：AIMS:The objective of this study was to examine baseline frailty status (including cognitive deficits) and important clinical outcomes, to inform shared decision-making in older adults receiving transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS:We conducted a prospective, observational study of 82 TA...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01525-z
更新日期：2020-03-19 00:00:00
abstract：OBJECTIVE:Attitude of healthcare providers toward older people is very important in the aging world. Neurologists contact older adults very frequently. We aimed to investigate the attitudes of neurologists toward older adults. MEASUREMENTS:We recorded participants age; sex; duration of clinical practice in neurology; ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0606-6
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327370
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03351076
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Walking is the core physical activity of older persons. The assessment of walking capacity is increasingly important for clinical purposes and clinical research. Differences between assessment tools and protocols for short walks to obtain gait characteristics can be responsible for changes, e.g., in...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01703-z
更新日期：2020-09-15 00:00:00
abstract：BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324544
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) patients with frailty syndrome (FS) are at higher risk of falling, decreased mobility, ability to perform the basic activities of daily living, frequent hospitalizations, and death. AIMS:The purpose of this study was to evaluate the correlations between FS and hospital readmissions, and t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0824-6
更新日期：2018-06-01 00:00:00
abstract：:Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01156-z
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The research aim was to study the associations of nature diversity with quality of life (QoL) and depressive symptoms among older people, and whether physical activity explains the associations. METHODS:Community-dwelling people aged 75-90 years (n = 848) living in Central Finland were interviewed in their ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0797-5
更新日期：2018-05-01 00:00:00
abstract：AIM:We report 3 cases of spontaneous insufficiency fracture of long bones, to promote awareness of this phenomenon to medical personnel dealing with long-term bedridden patients. METHODS:Cases were analyzed in the light of a literature review. RESULTS:Our patients were all women, who were severely debilitated and had...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324821
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Aging has several effects on auditory processing with the most important effect known as speech perception impairment in noise. AIMS:The aim of the present study was to investigate the effects of aging on spatial hearing using quick speech in noise (QSIN) and binaural masking level difference (BMLD) tests a...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01233-3
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:It is unclear whether motor-cognitive dual tasks predict cognitive decline better than either motor or cognitive tasks alone. AIMS:To examine the utility of the novel motor-cognitive dual-task test [Stepping Trail Making Test (S-TMT)], as a predictor of cognitive decline, and compare its predictive performa...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01714-w
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/BF03325216
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Functional brain imaging has shown that bilateral brain reorganization may occur after unilateral cerebral damage. The present study searched for evidence of bilateral motor control changes in gait in patients with chronic unilateral stroke. METHODS:Gait variables (temporal and spatial parameters, ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324759
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. AIMS:We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. METHODS:A total of 125 consecutive ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0507-0
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX®) as well as whet...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0634-2
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS:We aimed to explore the relationship betwee...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0847-z
更新日期：2018-01-01 00:00:00
abstract：:Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0838-0
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS:The cognitive functions of 98 elderly patients who were scheduled t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0519-9
更新日期：2016-12-01 00:00:00
abstract：:Most visual and cognitive functions are affected by aging over the lifespan. In this study, our aim was to investigate the loss in sensitivity to different classes of second-order stimuli-a class of stimuli supposed to be mainly processed in extrastriate cortex-in the aging population. These stimuli will then allow on...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1018-6
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emerge...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01735-5
更新日期：2020-11-18 00:00:00
abstract：AIM:The main purpose of the present study was to verify the feasibility of wearable inertial sensors (IMUs) in a clinical setting to screen gait and functional mobility in Italian older persons. In particular, we intended to verify the capability of IMUs to discriminate individuals with and without cognitive impairment...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01715-9
更新日期：2020-09-25 00:00:00
abstract：BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325234
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Osteoporosis is a common disease in elderly, characterized by poor bone quality as a result of alterations affecting trabecular bone. However, recent studies have described also an important role of alterations of cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0423-3
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Higher age is associated with reduced physical capability in the general population. The role of age and gender for physical performance in older adults who exercises regularly is, however, not clear, and there is also a lack of recommendations for outcomes to address physical performance for this population...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01190-x
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The incidence and costs of acute myocardial infarction (AMI) in Europe represent a substantial problem due to population aging. METHODS:Between 2001 and 2005, Italian hospitalization records were examined to evaluate hospital admissions and costs of AMI in adults aged ≥ 45 and in elderly people ≥ 65 or ≥ 75...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03337744
更新日期：2011-02-01 00:00:00
abstract：:Age-related macular disease (AMD) is the leading cause of legal blindness among the elderly in Western nations. The magnitude of the problem will undoubtedly grow, as age is a significant risk factor and the number of people aged 65 and over is projected to increase. The most frequent cause of severe visual loss assoc...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03327409
更新日期：2005-12-01 00:00:00
