Abstract:
BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emergency surgery. STUDY DESIGN:1024 patients older than 65 years who required urgent surgical procedures were prospectively recruited from 38 Italian centers participating to the multicentric FRAILESEL (Frailty and Emergency Surgery in the Elderly) study, between December 2016 and May 2017. A univariate analysis was carried out, with the purpose of developing a frailty index in emergency surgery called "EmSFI". Receiver operating characteristic curve analysis was then performed to test the accuracy of our predictive score. RESULTS:784 elderly patients were consecutively enrolled, constituting the development set and results were validated considering further 240 consecutive patients undergoing colorectal surgical procedures. A logistic regression analysis was performed identifying different EmSFI risk classes. The model exhibited good accuracy as regard to mortality for both the development set (AUC = 0.731 [95% CI 0.654-0.772]; HL test χ2 = 6.780; p = 0.238) and the validation set (AUC = 0.762 [95% CI 0.682-0.842]; HL test χ2 = 7.238; p = 0.299). As concern morbidity, our model showed a moderate accuracy in the development group, whereas a poor discrimination ability was observed in the validation cohort. CONCLUSIONS:The validated EmSFI represents a reliable and time-sparing tool, despite its discriminative value decreased regarding complications. Thus, further studies are needed to investigate specifically surgical settings, validating the EmSFI prognostic role in assessing the procedure-related morbidity risk.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Costa G,Bersigotti L,Massa G,Lepre L,Fransvea P,Lucarini A,Mercantini P,Balducci G,Sganga G,Crucitti A,ERASO (Elderly Risk Assessment, Surgical Outcome) Collaborative Study Group.doi
10.1007/s40520-020-01735-5subject
Has Abstractpub_date
2020-11-18 00:00:00eissn
1594-0667issn
1720-8319pii
10.1007/s40520-020-01735-5pub_type
杂志文章abstract::Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery t...
journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
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