Abstract:
BACKGROUND:Osteoporosis is a common disease in elderly, characterized by poor bone quality as a result of alterations affecting trabecular bone. However, recent studies have described also an important role of alterations of cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry (DXA) is a valid method to assess bone mineral density, in the presence of comorbidities real bone fragility is unable to be evaluated. The number of hip fractures is rising, especially in people over 85 years old. AIMS:The aim is to evaluate an alternative method so that it can indicate fracture risk, independent of bone mineral density (BMD). Femoral cortical index (FCI) assesses cortical bone stock using femur X-ray. METHODS:A retrospective study has been conducted on 152 patients with hip fragility fractures. FCI has been calculated on fractured femur and on the opposite side. The presence of comorbidities, osteoporosis risk factors, vitamin D levels, and BMD have been analyzed for each patient. RESULTS:Average values of FCI have been 0.42 for fractured femurs and 0.48 at the opposite side with a statistically significant difference (p = 0.002). Patients with severe hypovitaminosis D had a minor FCI compared to those with moderate deficiency (0.41 vs. 0.46, p < 0.011). 42 patients (27.6%) with osteopenic or normal BMD have presented low values of FCI. DISCUSSION AND CONCLUSION:A significant correlation among low values of FCI, comorbidities, severe hypovitaminosis D. and BMD in patients with hip fractures has been found. FCI could be a useful tool to evaluate bone fragility and to predict fracture risk even in the normal and osteopenic BMD patients.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Feola M,Rao C,Tempesta V,Gasbarra E,Tarantino Udoi
10.1007/s40520-015-0423-3subject
Has Abstractpub_date
2015-10-01 00:00:00pages
S45-50eissn
1594-0667issn
1720-8319pii
10.1007/s40520-015-0423-3journal_volume
27 Suppl 1pub_type
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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doi:10.1007/s40520-019-01239-x
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324842
更新日期:2006-10-01 00:00:00
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324618
更新日期:2005-08-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s40520-019-01297-1
更新日期:2020-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-015-0356-x
更新日期:2015-12-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0803-y
更新日期:2018-05-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-019-01191-w
更新日期:2019-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1099-2
更新日期:2019-11-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
abstract::Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00