Acute lymphocytic leukemia with eosinophilia: a case report and review of the literature.


:We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, myocardial infarction, and eosinophilic pneumonia. He was treated with high dose of steroids resulting in a rapid suppression of the eosinophilia. Two weeks later, the eosinophilia had relapsed, so a bone marrow aspiration was performed. Cytomorphological examination of the bone marrow showed typical ALL features, while flow cytometric analysis revealed an My+pre-B-ALL immunophenotype, and chromosome analysis of bone marrow showed a normal karyotype. He received chemotherapy according to the standard protocol for ALL and died from refractory respiratory failure and congestive heart failure immediately after antileukemic therapy. We review the literature and compare the demographics, clinical features, and outcomes of several cases and reported studies.


Aging Clin Exp Res


Song G,Liu H,Sun F,Gu L,Wang S




Has Abstract


2012-10-01 00:00:00














  • Post-operative degree of mobilization at two weeks predicts one-year mortality after hip fracture.

    abstract:BACKGROUND AND AIMS:Although several investigations have tested physical activity a few months or one year after hip fracture, only a few have assessed physical activity shortly after hip fracture. The aim of this study was to evaluate how physical function two weeks after hip fracture operation predicts 12-month morta...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Heinonen M,Karppi P,Huusko T,Kautiainen H,Sulkava R

    更新日期:2004-12-01 00:00:00

  • Association between vitamin D deficiency and long hospital stay in geriatric acute care unit: results from a pilot cohort study.

    abstract::Finding a biomarker of long length-of-stay (LOS) would provide a simple solution to target frail older inpatients at such risk. The aim of this study was to determine whether serum 25-hydroxyvitamin D (25OHD) deficiency, defined as serum concentration <25 nmol/L, was associated with long LOS among inpatients admitted ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Beauchet O,Launay CP,Maunoury F,de Decker L,Fantino B,Annweiler C

    更新日期:2013-04-01 00:00:00

  • Cellular and molecular mechanisms of new onset seizure generation.

    abstract::New onset epilepsy and seizures are common neurological disorders in aged people, second only to stroke and dementia. They are frequently related to other pathological conditions including stroke, trauma, tumors and neurological diseases whereas in about one-third of cases the origin is unknown. Besides the origin, th...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Losi G,Gomez-Gonzalo M,Zonta M,Chiavegato A,Carmignoto G

    更新日期:2019-11-15 00:00:00

  • Latin American Adult Immunisation Advocacy Summit: Overcoming regional barriers to adult vaccination.

    abstract::Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Barratt J,Mishra V,Acton M

    更新日期:2019-03-01 00:00:00

  • Life review with older women: an intervention to reduce depression and improve autobiographical memory.

    abstract:BACKGROUND AND AIMS:As life expectancy rises worldwide and the population grows older, psychopathology in older adults becomes a significant public health concern and intervention methods acquire renewed importance. The aim of the present study was to assess the efficacy of Life Review as an intervention strategy in wo...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Gonçalves DC,Albuquerque PB,Paul C

    更新日期:2009-08-01 00:00:00

  • Mild cognitive impairment, degenerative and vascular dementia as predictors of intra-hospital, short- and long-term mortality in the oldest old.

    abstract:BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Zekry D,Herrmann FR,Graf CE,Giannelli S,Michel JP,Gold G,Krause KH

    更新日期:2011-02-01 00:00:00

  • Measuring physical performance in highly active older adults: associations with age and gender?

    abstract:BACKGROUND:Higher age is associated with reduced physical capability in the general population. The role of age and gender for physical performance in older adults who exercises regularly is, however, not clear, and there is also a lack of recommendations for outcomes to address physical performance for this population...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Tangen GG,Robinson HS

    更新日期:2020-02-01 00:00:00

  • Osseointegration in the elderly.

    abstract::Osseointegration is a term that refers to the formation of a direct interface between an implant and bone without intervening soft tissue. Cementless femoral fixation in total hip arthroplasty is dependent on mechanical and biological factors that affect implant stability and long-term outcome. Osteoporosis leads to m...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Piarulli G,Rossi A,Zatti G

    更新日期:2013-10-01 00:00:00

  • Frailty syndrome and rehospitalizations in elderly heart failure patients.

    abstract:BACKGROUND:Heart failure (HF) patients with frailty syndrome (FS) are at higher risk of falling, decreased mobility, ability to perform the basic activities of daily living, frequent hospitalizations, and death. AIMS:The purpose of this study was to evaluate the correlations between FS and hospital readmissions, and t...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Uchmanowicz I,Kuśnierz M,Wleklik M,Jankowska-Polańska B,Jaroch J,Łoboz-Grudzień K

    更新日期:2018-06-01 00:00:00

  • Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.

    abstract::Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD). Acetylcholinesterase inhibitors (AChEI), the symptomatic therapy in AD, attenuate and delay the cognitive deficit by enhancing cholinergic synapses...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Benfante R,Di Lascio S,Cardani S,Fornasari D

    更新日期:2019-10-03 00:00:00

  • Old age as an "alternative" to illness: gerontological and medico-legal aspects.

    abstract::The current trend toward an ever increasing aging population forces society to face the problem of how to care for elderly people who are exposed to the risk of so-called "elder abuse," a phenomenon becoming increasingly widespread in Italy, as legislation does not provide a precise juridical definition of "elderly" n...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Molinelli A,Viale L,Landolfa MC,De Stefano F

    更新日期:2011-04-01 00:00:00

  • Prevalence of clinically relevant muscle weakness and its association with vitamin D status among older adults in Ecuador.

    abstract:BACKGROUND:Muscle weakness and 25-hydroxyvitamin D (25(OH)D) deficiency have been associated with adverse outcomes among older adults. However, little is known about the relationship between clinically relevant muscle weakness and 25(OH)D levels in Ecuador. AIMS:To examine the prevalence of muscle weakness and its ass...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Orces CH

    更新日期:2017-10-01 00:00:00

  • Characteristics and determinants of survival in oldest old nursing home residents admitted to hospital with an acute illness compared to their younger counterparts.

    abstract:BACKGROUND AND OBJECTIVES:The clinical problems and needs of our oldest old (≥85 years) are often substantially different from those of younger patients, and are arguably different from younger elderly patients (age 65-84). With the increasing number of frail oldest olds residing in Nursing Homes (NH), we aim to identi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Honney K,Trepte NJ,Parker RA,Patel J,Mallinson R,Sultanzadeh SJ,Potter JF,Myint PK

    更新日期:2014-04-01 00:00:00

  • Gender differences and burden of chronic conditions: impact on quality of life among the elderly in Taiwan.

    abstract:BACKGROUND:Multiple chronic conditions affect people's health-related quality of life (QoL) and the distributions of the conditions may differ between genders. Our goal was to examine gender differences in chronic conditions and QoL among community-living elderly in Taiwan and to examine whether differences in QoL betw...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Yu T,Enkh-Amgalan N,Zorigt G,Hsu YJ,Chen HJ,Yang HY

    更新日期:2019-11-01 00:00:00

  • The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery.

    abstract:BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emerge...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Costa G,Bersigotti L,Massa G,Lepre L,Fransvea P,Lucarini A,Mercantini P,Balducci G,Sganga G,Crucitti A,ERASO (Elderly Risk Assessment, Surgical Outcome) Collaborative Study Group.

    更新日期:2020-11-18 00:00:00

  • Incorporation of a patient navigator into a secondary fracture prevention program identifies barriers to patient care.

    abstract:INTRODUCTION:Patient navigation improves outcomes in various clinical contexts, but has not been evaluated in secondary fracture prevention. METHODS:We retrospectively reviewed charts of patients, age 50 + from April to October, 2016 hospitalized with fragility fracture contacted by a patient navigator. Patients were ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Jia KQ,Southerland L,Phieffer L,Stephens JA,Ing SW

    更新日期:2020-12-01 00:00:00

  • Multi-sensory training and wrist fractures: a randomized, controlled trial.

    abstract:BACKGROUND:Asymmetric vestibular function, decreased plantar sensation, postural control and functional ability have been associated with fall-related wrist fractures. OBJECTIVE:To investigate whether multi-sensory training (MST) improves postural control, vestibular function, foot sensation and functional ability amo...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Baldursdottir B,Whitney SL,Ramel A,Jonsson PV,Mogensen B,Petersen H,Kristinsdottir EK

    更新日期:2020-01-01 00:00:00

  • Effect of a mixed-exercise program on physical capacity and sedentary behavior in older adults during cancer treatments.

    abstract:BACKGROUND:Aging, cancer and its treatment all contribute to increase the risk of deconditioning and sedentary behaviors. Mixed exercise is recognized to counteract the effects of aging and deconditioning as well as improving physical capacity during cancer treatment in adults. AIMS:To determine the impact of a mixed ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Maréchal R,Fontvieille A,Parent-Roberge H,Fülöp T,Riesco E,Pavic M,Dionne IJ

    更新日期:2019-11-01 00:00:00

  • Hydration status of community-dwelling seniors.

    abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Morgan AL,Masterson MM,Fahlman MM,Topp RV,Boardley D

    更新日期:2003-08-01 00:00:00

  • Effects of denosumab on cortical and trabecular microarchitecture: evidences from clinical studies.

    abstract::Excess of bone remodeling is still the major pathogenic factor in involutional osteoporosis. This phenomenon is linked to an imbalance between neoformation (by osteoblasts) and resorption (by osteoclasts). Recently, research in drug development is focused on new and more "physiological" approach to balance bone remode...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Iolascon G,Resmini G,Tarantino U

    更新日期:2013-10-01 00:00:00

  • Effects of participatory art-based painting workshops in geriatric inpatients: results of a non-randomized open label trial.

    abstract:BACKGROUND:Art-based activities like painting workshops demonstrated health benefits in older individuals living in home care facilities. Few studies examined the effects of painting workshops in geriatric inpatients. AIM:The study aims to examine whether the participation in painting workshops performed in patients a...

    journal_title:Aging clinical and experimental research

    pub_type: 临床试验,杂志文章


    authors: Beauchet O,Lafleur L,Remondière S,Galery K,Vilcocq C,Launay CP

    更新日期:2020-12-01 00:00:00

  • Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging.

    abstract:BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Viidik A,Skalicky M

    更新日期:2003-12-01 00:00:00

  • Sarcopenic obesity: research advances in pathogenesis and diagnostic criteria.

    abstract::Sarcopenic obesity (SO) refers to an obesity disease accompanied by low skeletal muscle quality, strength and/or function, which is more common in the elderly and seriously affects their quality of life and can lead to falls, unstable walking, balance disorders and fractures in the elderly. The increase in aging popul...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Xie WQ,Xiao GL,Fan YB,He M,Lv S,Li YS

    更新日期:2019-12-16 00:00:00

  • The effect of individualized, theory-based counselling intervention on active aging and quality of life among older people (the AGNES intervention study).

    abstract:BACKGROUND:We define active aging as a striving for activities as per one's goals, capacities and opportunities. AIM:To test the 1-year counselling intervention effects on active aging. METHODS:In this two-arm single-blinded randomized controlled trial, the intervention group received individually tailored counsellin...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Rantanen T,Hassandra M,Pynnönen K,Siltanen S,Kokko K,Karavirta L,Kauppinen M,Sipilä S,Saajanaho M,Portegijs E

    更新日期:2020-10-01 00:00:00

  • A carbohydrate-rich drink shortly before surgery affected IGF-I bioavailability after a total hip replacement. A double-blind placebo controlled study on 29 patients.

    abstract:BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Aronsson A,Al-Ani NA,Brismar K,Hedström M

    更新日期:2009-04-01 00:00:00

  • Mortality among elderly receiving long-term care: a longitudinal cohort study.

    abstract:BACKGROUND AND AIMS:To investigate mortality, determinants of mortality, and time until death among elderly subjects receiving public long-term care. METHODS:This study comprises 626 respondents (age: 65-98 years). Data were collected for two cohorts (2001 and 2002). Cox regression analysis was used to identify determ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Jakobsson U,Hallberg IR

    更新日期:2006-12-01 00:00:00

  • Home-made oral supplement as nutritional support of old nursing home residents, who are undernourished or at risk of undernutrition based on the MNA. A pilot trial. Mini Nutritional Assessment.

    abstract:AIMS:The aim of this pilot study was to examine the effect of a home-made oral supplement on body weight and energy intake of old people residing in a nursing home. METHODS:Sixty-six old (65+ years) nursing home residents were included and divided into three classes according to their Mini Nutritional Assessment (MNA)...

    journal_title:Aging clinical and experimental research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beck AM,Ovesen L,Schroll M

    更新日期:2002-06-01 00:00:00

  • Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease.

    abstract:BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Galizia G,Cacciatore F,Testa G,Della-Morte D,Mazzella F,Langellotto A,Raucci C,Gargiulo G,Ferrara N,Rengo F,Abete P

    更新日期:2011-04-01 00:00:00

  • Initiation of antipsychotics after moving to residential aged care facilities and mortality: a national cohort study.

    abstract:BACKGROUND:There is a high burden of antipsychotic use in residential aged care facilities (RACFs) and there is concern regarding potential inappropriate prescribing of antipsychotics in response to mild behavioural symptoms. Antipsychotic use has been associated with a higher risk of mortality in community-dwelling ol...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Harrison SL,Sluggett JK,Lang C,Whitehead C,Crotty M,Corlis M,Wesselingh S,Inacio MC

    更新日期:2020-03-11 00:00:00

  • External hip protectors in home-dwelling older persons.

    abstract:BACKGROUND AND AIMS:External hip protectors have been shown to have a good preventive effect against hip fractures in many studies. However, these studies were carried out either entirely or mostly among older persons living in institutions. The aim of this study was to investigate whether health nurses can, after brie...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Heikinheimo R,Jalonen-Männikkö A,Asumaniemi H,Lehtomäki E

    更新日期:2004-02-01 00:00:00