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Serum superoxide dismutase and malondialdehyde levels in a group of Chinese patients with age-related macular degeneration.

Abstract：

BACKGROUND AND AIMS:The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). METHODS:Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, geographic atrophy, and wet) and 34 healthy controls matched with age and sex. RESULTS:Serum MDA levels were significantly higher in AMD (3.68 ± 1.06 nmol/mL) than in controls (2.83 ± 0.43 nmol/mL; p=0.000), and was significantly higher in wet AMD (3.79 ± 0.79 nmol/mL) than in early dry AMD (3.26 ± 0.99 nmol/mL; p=0.038). Serum SOD activity was significantly higher in AMD (87.12 ± 13.22 U/mL) than in controls (79.91 ± 11.80 U/mL; p=0.012), and slightly higher in wet AMD (89.52 ± 16.25 U/mL) than in GA (83.62 ± 9.75 U/mL; p=0.275) and early dry AMD (81.64 ± 18.90 U/mL; p=0.093). There was a positive correlation between serum MDA levels and SOD activities in AMD patients and controls (r=0.320, p=0.002). CONCLUSIONS:The observed increase in SOD activity in our study may be related to increased MDA levels, as a compensatory regulation in response to oxidative stress in AMD patients. The present data also demonstrate that oxido-reduction disturbance may be hypothesized in the pathogenesis of AMD.

journal_name

Aging Clin Exp Res

journal_title

Aging clinical and experimental research

authors

Jia L,Dong Y,Yang H,Pan X,Fan R,Zhai L

doi

10.1007/BF03324965

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

264-7

issue

4

eissn

1594-0667

issn

1720-8319

pii

8083

journal_volume

23

pub_type

杂志文章

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