Abstract：
BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular action, such as control of balance, may therefore be negatively affected by these changes. Recent investigations of smaller intrinsic hand muscles have suggested that strength training may attenuate the normal age-related decrease in strength and control of force resulting in increased strength and control. The effects of strength training on the larger, more powerful, anti-gravity muscle of the quadriceps, where age-related changes are noted earlier, are unknown. Thus, the purpose of this study was to assess the effects of 12 weeks of high intensity strength training on strength and the ability to control muscular force in untrained older adults. METHODS:Twenty-two subjects aged 59-83 years (11 males, 11 females) were compared to 5 untrained, age-matched controls 58-76 years of age (3 females, 2 males). Maximal isometric knee extensor strength and control of force at 30, 60, and 90% of maximum were measured at 0, 6, and 12 weeks. RESULTS:Significant increases in quadriceps strength were noted in the exercise group but neither group showed a change in the ability to control sub-maximal forces. CONCLUSIONS:These findings suggest that high intensity strength training may be efficacious for improving strength but does not improve the ability to control sub-maximal isometric forces.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Bellew JWdoi
10.1007/BF03324415subject
Has Abstractpub_date
2002-02-01 00:00:00pages
35-41issue
1eissn
1594-0667issn
1720-8319journal_volume
14pub_type
杂志文章abstract：BACKGROUND:SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. AIMS:To create a Japanese version of the SARC-F (SARC-F-J), a questionnaire for diabetic patients, and to investigate its reliability and validity. METHODS:This...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0668-5
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Poor adherence to medications is a major health concern especially among older subjects. To plan future studies to improve adherence, an epidemiological study, called "Fiesole Misurata", was conducted. The aim of the present paper was to verify the representativeness of the database in evaluating th...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0060-7
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324953
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Peptydil prolyl cis-trans isomerase (PIN-1), which specifically regulates the conformational changes following phosphorylation of several proteins, targets the inactive hyper-phosphorylated tau on the Thr231-Pro motif and directly restores its biological function. Interestingly, PIN-1 is oxidatively...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324722
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0943-8
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Fall-induced deaths of elderly people are a major problem. AIM AND METHODS:Using the Official Cause-of-Death Statistics of Finland, we aimed to determine the current trends in the number and age-adjusted incidence (per 100,000 persons) of fall deaths among older Finns by taking into account 50 years or olde...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0898-9
更新日期：2018-09-01 00:00:00
abstract：AIM:To evaluate the role of balance and gait disorders, comorbidities and laboratory abnormalities in the occurrence of falls in an institutionalized elderly population. METHODS:We made a non-interventional, prospective, observational study in elderly institutionalized people. Comorbidities and information on treatmen...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0304-1
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01420-2
更新日期：2019-11-22 00:00:00
abstract：:Dysfunctional T-cell immunity contributes to susceptibility to infectious disease in the elderly. A characteristic feature of this "immunosenescence" is the predominance of clonal expansions of CD8 cells and decreased diversity of the T-cell antigen receptor repertoire. Lifelong chronic antigenic stress commonly cause...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03327436
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND AIMS:To assess the incidence and prognostic value of hypoglycemia in hospitalized non-diabetic elderly patients. METHODS:An observational retrospective study, with a 3-year follow-up, was performed in a series of 678 patients aged over 65 years, admitted between January 1 2001 and December 31 2001 to th...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324842
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-017-0830-8
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The aging trajectory from a state of robustness and good health proceeds from sarcopenia to frailty followed by disability and death due to decline in skeletal muscle mass and function. Sarcopenia is now formally recognized as a muscle disease with an ICD-10-MC diagnosis code. The autophagic response seems t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01642-9
更新日期：2020-06-27 00:00:00
abstract：BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0746-3
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND AIMS:This study aimed at examining factors related to osteoarthritis (OA) symptom severity in African American and Caucasian veterans (n=202). METHODS:OA symptom severity (lower extremity pain, stiffness, and physical function) was measured by the Western Ontario and McMaster Universities Osteoarthritis...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324608
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND AIMS:One of the factors playing a role in both the aging process and the etiopathogenesis of primary hypertension is oxidative stress. The purpose of this work was to estimate the production of nitric oxide (NO), oxidase activity of ceruloplasmin (Cp) and level of malondialdehyde (MDA), the end-product o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324634
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Bone structure, geometry and mineral content represent complex traits with a significant heritable component. However, the specific contributing genes have not been unambiguously identified. The aim of the present cross-sectional study was to analyse an association between heel ultrasound measuremen...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324584
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS:To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the facto...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0742-7
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Despite the increase in research on delirium, it remains underdiagnosed and difficult to manage, and the outcome is poor especially in older people. AIMS:To identify the clinically diagnosed rates of delirium, the possible aetiologies, to describe treatment, number and type of psychotropic medication used a...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0227-x
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to develop a Turkish version of the Nottingham Extended Activities of Daily Living Scale (NEADLS) and to assess its reliability and validity. METHODS:Sixty healthy volunteers over 67 years old were included in the study. After translation, the Turkish version of the scale ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325144
更新日期：2008-10-01 00:00:00
abstract：AIMS:The aim of this pilot study was to examine the effect of a home-made oral supplement on body weight and energy intake of old people residing in a nursing home. METHODS:Sixty-six old (65+ years) nursing home residents were included and divided into three classes according to their Mini Nutritional Assessment (MNA)...
journal_title：Aging clinical and experimental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03324439
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8757
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327370
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325234
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emerge...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01735-5
更新日期：2020-11-18 00:00:00
abstract：BACKGROUND:Sepsis is more common in the elderly. TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺. Little is known about how innate immunity is altered in healthy human aging that predisposes to sepsis. AIMS AND...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1064-0
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of the present study is to describe the effects of aging on various cognitive domains (global cognitive function, executive function, motor speed) in a population sample of elderly men, and to describe how their age-related changes are influenced by education, depression, or prevalent cerebr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324624
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Sagittal spinal alignment is an important determinant for proper spinal function. Alterations in spinal alignment may serve as leading factor for diminished body biomechanics. Although increased age is suggested to be associated with changes in lumbosacral alignment, in turn body posture, this is still a cur...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0274-3
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0112-z
更新日期：2013-10-01 00:00:00
abstract：:We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0383-7
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Osteoporosis and fall fractures are increasing problems amongst the elderly. The aim of this study was to explore whether combined population-based and individual interventions directed at risk factors for osteoporosis and falls result in behavioral changes in an elderly population. METHODS:A quasi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324654
更新日期：2006-06-01 00:00:00
