Abstract:
:Senescence of the brain seems to be related to increased levels of free oxygen radical (FOR). FOR may damage macromolecular compounds such as: proteins, lipids, and DNA. In the aging brain, increased FOR levels damage DNA, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA). In DNA they damage single and double strands, leading to mutations in mtDNA and nDNA. Damage to mtDNA seems to result in decay of mitochondria, decreased production of ATP, and in the activation of the apoptotic process. In the aging brain, apoptosis does not seem to be activated in wild-type p53-expressing cells because the elevated levels of the p53 protein are no longer accompanied by decreased levels of the Bcl-2 protein and increased levels of the Bax protein. It seems that, in the aging brain, changes in the metabolism of neurons may lead to their decreased numbers in the cerebral and cerebellar cortex, hippocampus, basal nucleus of Meynert, locus ceruleus, and substantia nigra, as well as to decreased numbers of synapses and disturbed stimulation of synaptic plasticity in the senescent brain. Simultaneously, a decrease in neurogenesis in the aging brain may lead to a decline in the maintenance of tissue integrity, function, and regenerative response. Environmental enrichment and physical activity may improve hippocampal neurogenesis and induce neuronal plasticity. The morphological lesions in the senescent brain are undoubtedly followed by a disturbed balance between various types of neurons in the CNS. Nevertheless, the high plasticity of the CNS in humans most probably does not allow for the development of abnormalities in higher functions.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Dorszewska Jdoi
10.1007/s40520-013-0004-2subject
Has Abstractpub_date
2013-04-01 00:00:00pages
25-34issue
1eissn
1594-0667issn
1720-8319journal_volume
25pub_type
杂志文章,评审abstract:BACKGROUND:Interprofessional collaborative practice (ICP) is currently recommended for the delivery of high-quality integrated care for older people. Frailty prevention and management are key elements to be tackled on a multi-professional level. AIM:This study aims to develop a consensus-based European multi-professio...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-019-01455-5
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Although several investigations have tested physical activity a few months or one year after hip fracture, only a few have assessed physical activity shortly after hip fracture. The aim of this study was to evaluate how physical function two weeks after hip fracture operation predicts 12-month morta...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327405
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The SarQoL® is a recently developed quality of life questionnaire specific to sarcopenia. AIM:To compare the quality of life (QoL) of subjects identified as sarcopenic with that of non-sarcopenic subjects when using six different operational definitions of sarcopenia. METHODS:Participants of the SarcoPhAge...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0866-9
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS:The cognitive functions of 98 elderly patients who were scheduled t...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0519-9
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:A lack of understanding of the causes of attrition in longitudinal studies of older adults may lead to higher attrition rates and bias longitudinal study results. In longitudinal epidemiological studies of Alzheimer's disease and related dementias, high rates of attrition may cause a systematic underestimatio...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1087-6
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Poor adherence to medications is a major health concern especially among older subjects. To plan future studies to improve adherence, an epidemiological study, called "Fiesole Misurata", was conducted. The aim of the present paper was to verify the representativeness of the database in evaluating th...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0060-7
更新日期:2013-08-01 00:00:00
abstract:AIMS:1) to evaluate the prevalence of diabetes mellitus (DM) in a geriatric ward; 2) to assess the efficacy and safety of insulin analogs in elderly inpatients over 65 years of age. METHODS:We analysed the medical records of 1851 elderly inpatients admitted to our geriatric clinic from March 2009 to September 2011, to...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Walking is the core physical activity of older persons. The assessment of walking capacity is increasingly important for clinical purposes and clinical research. Differences between assessment tools and protocols for short walks to obtain gait characteristics can be responsible for changes, e.g., in...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01703-z
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/7519
更新日期:2012-02-01 00:00:00
abstract:AIMS:The aim of this pilot study was to examine the effect of a home-made oral supplement on body weight and energy intake of old people residing in a nursing home. METHODS:Sixty-six old (65+ years) nursing home residents were included and divided into three classes according to their Mini Nutritional Assessment (MNA)...
journal_title:Aging clinical and experimental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03324439
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Muscle weakness and 25-hydroxyvitamin D (25(OH)D) deficiency have been associated with adverse outcomes among older adults. However, little is known about the relationship between clinically relevant muscle weakness and 25(OH)D levels in Ecuador. AIMS:To examine the prevalence of muscle weakness and its ass...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0678-3
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The Short Physical Performance Battery (SPPB) and the De Morton Mobility Index (DEMMI) are two commonly used instruments to assess mobility in older patients. AIMS:To compare the two assessments in acute senior trauma patients with regard to sensitivity to change during an acute care, and prediction of disc...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01249-9
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Changes in some rhythmometric parameters have been reported in the elderly as a consequence of both structural and neurochemical changes occurring in the central nervous system. Since alterations of lipid and lipoprotein metabolism are directly involved in several age-related disorders, the aim of t...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324422
更新日期:2002-04-01 00:00:00
abstract::Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01156-z
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:In addition to the normal process of ageing, frailty, defined as a geriatric syndrome, is becoming more prevalent. Around 10% of people over 65 years and 25-50% of those aged over 85 years are frail. Frail elderly are more vulnerable to external stressors and have an increased risk of adverse health outcomes...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0918-9
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. AIMS:To create a Japanese version of the SARC-F (SARC-F-J), a questionnaire for diabetic patients, and to investigate its reliability and validity. METHODS:This...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0668-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324693
更新日期:2007-06-01 00:00:00
abstract::Visual identification of vertebral fractures from spinal radiographs makes use of operator expertise in ruling out non-fracture deformities or normal variants. Morphometric X-ray absorptiometry (MXA) has recently been developed to assess vertebral deformity status quantitatively by dual energy X-ray absorptiometry (DX...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Glycemic control in geriatric patients with type 2 diabetes (T2DM) remains clinically challenging. The objective of this study was to compare the safety and efficacy of insulin lispro in patients C65 years (geriatric) to those\65 years (non-geriatric), using a metaanalysis of randomized controlled c...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,meta分析
doi:10.1007/s40520-013-0125-7
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/BF03325216
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Hip and knee replacements have become increasingly common in the older population but the prevalence of these procedures and the potential impact on functioning towards the end of life have not been previously described. The aim of this study was to estimate the rates and distribution of hip and kne...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324481
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Multimorbidity in older adults needs to be assessed as it is a risk factor for disability, cognitive decline, and mortality. AIMS:A community-based longitudinal study was performed to determine the incidence and to identify possible predictors of multimorbidity among multiethnic older adults population in M...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1007-9
更新日期:2019-02-01 00:00:00
abstract::Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0278-z
更新日期:2015-06-01 00:00:00
abstract:AIM:Falls are a significant problem for older people, but are few studies of the risk of falling in residents of nursing homes in Japan. We aimed to investigate the risk factors for falls and the association of medication use and falls in nursing home residents in Japan. METHODS:This case-control study reviewed the re...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01265-9
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03351076
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0025-x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03325244
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0331-6
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Elderly people experience a gradual loss of muscle strength and a reduction of serum levels of vitamin D and of vitamin D receptor expression in skeletal muscle cells. AIMS:The aim of our study was to evaluate the association among serum levels of 25-hydroxy-vitamin D [25(OH)D3], muscle strength, and physic...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0405-5
更新日期:2015-10-01 00:00:00
abstract::Physical frailty (PF) and sarcopenia are major health issues in geriatric populations, given their high prevalence and association with several adverse outcomes. Nevertheless, the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation. Existing definitional ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-016-0708-1
更新日期:2017-02-01 00:00:00