Abstract:
BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage in the poor cognitive performance observed in patients with stroke. METHODS:Atahualpa residents aged ≥60 years were identified during a door-to-door survey and invited to undergo brain MRI for identification of stroke lesions and white matter hyperintensities (WMH) of presumed vascular origin. Cognitive performance was evaluated by the use of the Montreal Cognitive Assessment (MoCA). Using a generalized linear model, we examined the association between MoCA score, stroke and WMH, after adjusting for demographics, education, vascular risk factors, depression and edentulism. RESULTS:Out of 311 persons aged ≥60 years, 242 (78 %) were enrolled. MRI showed strokes in 39 (16 %) and moderate-to-severe WMH in 52 (22 %) cases. Mean MoCA score was 18.5 ± 4.7 in the entire population. When participants were stratified according to the median age of the population (67 years), the generalized linear model showed that MoCA scores were not different in younger persons irrespective of the presence of stroke or WMH. In contrast, increased age associated with lower MoCA scores in persons with WMH (p = 0.002) or with both stroke and WMH (p = 0.003), but not in those with stroke without WMH (p = 0.087). CONCLUSIONS:Interaction of age and diffuse subcortical damage are major determinants for poor cognitive performance among stroke patients.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Del Brutto OH,Mera RM,Zambrano M,Lama Jdoi
10.1007/s40520-015-0331-6subject
Has Abstractpub_date
2015-10-01 00:00:00pages
647-52issue
5eissn
1594-0667issn
1720-8319pii
10.1007/s40520-015-0331-6journal_volume
27pub_type
杂志文章abstract:BACKGROUND AND AIMS:Despite evidence of cognitive impairment and difficulties in performing daily activities among elderly people with major depression, studies implementing objective performance-based evaluation of functional deficits in this patient population are scarce. With the aid of a computerized device we exam...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324463
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324759
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral bl...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327392
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abstract::This case report concerns an elderly woman referred with a 6-month history of rising and falling fever in the range 38-40°C. She was examined repeatedly by her family doctor and given various antibiotic treatments before being hospitalized in our geriatric unit. Laboratory tests and microbiological studies led to a di...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/8179
更新日期:2012-10-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01449-3
更新日期:2020-11-01 00:00:00
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03337718
更新日期:2005-02-01 00:00:00
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doi:10.1007/s40520-020-01665-2
更新日期:2020-09-08 00:00:00
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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journal_title:Aging clinical and experimental research
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
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journal_title:Aging clinical and experimental research
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更新日期:2020-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-017-0830-8
更新日期:2018-07-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00