Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.


BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using a rat model. METHODS:Rapid resolution liquid chromatography/electrospray ionization quadrupole-time of flight mass spectrometry (RRLC/ESI-Q-TOFMS) was employed to analyze metabolomic profiling of urine samples from aging rats who underwent caloric restriction (CR; n=7) or were provided a normal diet (N; n=8) for 12 weeks time. Multivariate data analysis was performed on the mass data of metabolomic profiles to uncover the differences between the CR and N groups. RESULTS:CR treatment led to manifest metabolic changes in aging rats, and fifteen urinary metabolites including hypoxanthine, hippurate, dimethylglycine and creatinine were significantly different in the rat groups. CONCLUSION:Our study demonstrates the high reliability of the HPLC-based metabolomic approach towards the study of anti-aging effects induced by CR, while the urinary metabolites we identified may become potential biomarkers of aging.


Aging Clin Exp Res


Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C




Has Abstract


2012-02-01 00:00:00














  • Cognitive performance in community-dwelling older adults with stroke and the contribution of age and diffuse subcortical damage: a population-based study in rural Ecuador (The Atahualpa Project).

    abstract:BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Del Brutto OH,Mera RM,Zambrano M,Lama J

    更新日期:2015-10-01 00:00:00

  • Hydration status of community-dwelling seniors.

    abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Morgan AL,Masterson MM,Fahlman MM,Topp RV,Boardley D

    更新日期:2003-08-01 00:00:00

  • Depressed mood: changes during a five-year follow-up in 75-year-old men and women in three Nordic localities.

    abstract::The aim of the study was to look firstly at the changes that occurred in depressive symptomatology over a 5-year period among originally 75-year-old residents in three Nordic localities: Glostrup in Denmark, Göteborg in Sweden and Jyväskylä in Finland, and secondly, at some selected variables if they predicted depress...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Heikkinen RL,Berg S,Avlund K,Tömäkangas T

    更新日期:2002-06-01 00:00:00

  • The role of cognitive reserve as mediator for addition and multiplication skills in late adulthood.

    abstract:BACKGROUND:The role played by cognitive reserve for the maintenance of numeracy skills in late adulthood is still not sufficiently explored. AIMS:This study mainly investigated whether cognitive reserve (i.e., vocabulary) mediates on the relationship between non-verbal reasoning and addition and multiplication skills ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Mulas I,Ruiu M,Fastame MC

    更新日期:2020-06-18 00:00:00

  • Motivators for Alzheimer's disease clinical trial participation.

    abstract:BACKGROUND:Alzheimer's disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations. METHODS:Participants, or their caregivers, from AD treatment and prevention CTs ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bardach SH,Holmes SD,Jicha GA

    更新日期:2018-02-01 00:00:00

  • The effect of aging on gait parameters in able-bodied older subjects: a literature review.

    abstract:BACKGROUND:Gait disorders are common in the elderly populations, and their prevalence increases with age. Abnormal gait has been associated with greater risk for adverse outcomes in older adults, such as immobility and falls, which in turn lead to loss of functional independence and death. AIM:The purpose of this revi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Aboutorabi A,Arazpour M,Bahramizadeh M,Hutchins SW,Fadayevatan R

    更新日期:2016-06-01 00:00:00

  • A carbohydrate-rich drink shortly before surgery affected IGF-I bioavailability after a total hip replacement. A double-blind placebo controlled study on 29 patients.

    abstract:BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Aronsson A,Al-Ani NA,Brismar K,Hedström M

    更新日期:2009-04-01 00:00:00

  • Physical frailty in older people with severe aortic stenosis.

    abstract:BACKGROUND:Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. AIMS:We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. METHODS:A total of 125 consecutive ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Fukui S,Kawakami M,Otaka Y,Ishikawa A,Mizuno K,Tsuji T,Hayashida K,Inohara T,Yashima F,Liu M

    更新日期:2016-12-01 00:00:00

  • Suicide and euthanasia in late life.

    abstract::Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, persona...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: De Leo D,Spathonis K

    更新日期:2003-04-01 00:00:00

  • Assessing competence at a higher level among older adults: development of the Japan Science and Technology Agency Index of Competence (JST-IC).

    abstract:BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Iwasa H,Masui Y,Inagaki H,Yoshida Y,Shimada H,Otsuka R,Kikuchi K,Nonaka K,Yoshida H,Yoshida H,Suzuki T

    更新日期:2018-04-01 00:00:00

  • Measurement of lean body mass using bioelectrical impedance analysis: a consideration of the pros and cons.

    abstract::The assessment of body composition has important applications in the evaluation of nutritional status and estimating potential health risks. Bioelectrical impedance analysis (BIA) is a valid method for the assessment of body composition. BIA is an alternative to more invasive and expensive methods like dual-energy X-r...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Sergi G,De Rui M,Stubbs B,Veronese N,Manzato E

    更新日期:2017-08-01 00:00:00

  • Oral diadochokinesis is related to decline in swallowing function among community-dwelling Japanese elderly: a cross-sectional study.

    abstract:BACKGROUND:Since oral organs function in the first stage of the swallowing process, it is possible that decline in swallowing function can be partly related to oral frailty. AIMS:The purpose of this study was to investigate the association between swallowing function and oral function among community-dwelling elderly ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Takeuchi N,Sawada N,Ekuni D,Morita M

    更新日期:2020-04-18 00:00:00

  • Income differentials in functional disability in old age: relative risks of onset, recovery, decline, attrition and mortality.

    abstract:BACKGROUND AND AIMS:Socioeconomic status (SES) differences in health decline in late life may be underestimated, because the relatively higher risks of attrition of lower-SES persons are seldom taken into account. This longitudinal study aimed at comparing income differences in the course of disability, non-mortality a...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Broese van Groenou MI,Deeg DJ,Penninx BW

    更新日期:2003-04-01 00:00:00

  • Incorporation of a patient navigator into a secondary fracture prevention program identifies barriers to patient care.

    abstract:INTRODUCTION:Patient navigation improves outcomes in various clinical contexts, but has not been evaluated in secondary fracture prevention. METHODS:We retrospectively reviewed charts of patients, age 50 + from April to October, 2016 hospitalized with fragility fracture contacted by a patient navigator. Patients were ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Jia KQ,Southerland L,Phieffer L,Stephens JA,Ing SW

    更新日期:2020-12-01 00:00:00

  • Validity of the interRAI Acute Care based on test content: a multi-center study.

    abstract:BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Wellens NI,Deschodt M,Boonen S,Flamaing J,Gray L,Moons P,Milisen K

    更新日期:2011-10-01 00:00:00

  • Acute lymphocytic leukemia with eosinophilia: a case report and review of the literature.

    abstract::We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Song G,Liu H,Sun F,Gu L,Wang S

    更新日期:2012-10-01 00:00:00

  • Evaluation of an osteoporosis and fall risk intervention program for community-dwelling elderly. A quasi-experimental study of behavioral modifications.

    abstract:BACKGROUND AND AIMS:Osteoporosis and fall fractures are increasing problems amongst the elderly. The aim of this study was to explore whether combined population-based and individual interventions directed at risk factors for osteoporosis and falls result in behavioral changes in an elderly population. METHODS:A quasi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Grahn Kronhed AC,Blomberg C,Löfman O,Timpka T,Möller M

    更新日期:2006-06-01 00:00:00

  • The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health.

    abstract::Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Veronese N,Reginster JY

    更新日期:2019-06-01 00:00:00

  • Is it safe and useful, laparoscopic peritoneal lavage in the treatment of acute diverticulitis of octogenarian patients? A multicenter retroprospective observational study.

    abstract:BACKGROUND:Diverticular disease of the colon also affects older people. Generally, older patients with diverticulitis may be regarded as too risky to undergo surgery. This retroprospective multicentric observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage (LPL) in elderly patients...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Boselli C,Gemini A,Cirocchi R,Grassi V,Avenia S,Polistena A,Sanguinetti A,Pironi D,Santoro A,Tabola R,Burattini MF,Avenia N

    更新日期:2017-02-01 00:00:00

  • Nutritional status, physical performance and disability in the elderly of the Peruvian Andes.

    abstract:BACKGROUND:Although nutritional status plays an important part in the physical performance and disability of older people, this relationship has been little studied in developing countries. AIMS:A study on the effects of nutritional status on the physical performance and functional status of elderly people living in r...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Tramontano A,Veronese N,Giantin V,Manzato E,Rodriguez-Hurtado D,Trevisan C,De Zaiacomo F,Sergi G

    更新日期:2016-12-01 00:00:00

  • Educational vaccine tools: the French initiative.

    abstract::Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Belmin J,Bourée P,Camus D,Guiso N,Jeandel C,Trivalle C,Veyssier P

    更新日期:2009-06-01 00:00:00

  • Comparing the influence of exercise intensity on brain-derived neurotrophic factor serum levels in people with Parkinson's disease: a pilot study.

    abstract:INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a p...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: O'Callaghan A,Harvey M,Houghton D,Gray WK,Weston KL,Oates LL,Romano B,Walker RW

    更新日期:2020-09-01 00:00:00

  • The system of care for the elderly in Thailand: capitalizing from an integrated community-based health system through reform.

    abstract::Thailand is facing a dramatic challenge of how to ensure good health and quality of life for its rapidly increasing number of elderly citizens. The modern health services system established a century ago has a larger proportion of public providers, but only 35-40% share public spending on health. The health services a...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Chunharas S

    更新日期:2002-08-01 00:00:00

  • Educational strategies to train health care professionals across the education continuum on the process of frailty prevention and frailty management: a systematic review.

    abstract:BACKGROUND:In addition to the normal process of ageing, frailty, defined as a geriatric syndrome, is becoming more prevalent. Around 10% of people over 65 years and 25-50% of those aged over 85 years are frail. Frail elderly are more vulnerable to external stressors and have an increased risk of adverse health outcomes...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Windhaber T,Koula ML,Ntzani E,Velivasi A,Rizos E,Doumas MT,Pappas EE,Onder G,Vetrano DL,Roudriguez Laso A,Roudriguez Manjas L,Illario M,Roller-Wirnsberger RE,ADVANTAGE JA WP8 group.

    更新日期:2018-12-01 00:00:00

  • Concordance between clinical and radiographic evaluations of knee osteoarthritis.

    abstract:BACKGROUND:Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS:We aimed to explore the relationship betwee...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Parsons C,Fuggle NR,Edwards MH,Goulston L,Litwic AE,Jagannath D,van der Pas S,Cooper C,Dennison EM,EPOSA Research Group.

    更新日期:2018-01-01 00:00:00

  • Lack of association between appendectomy and Parkinson's disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Accumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson's disease (PD). The appendix contains abundant α-synuclein and lacks a blood-tissue barrier, suggesting that appendectomy might reduce α-synuclein aggregation, and therefore the ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,meta分析,评审


    authors: Lu HT,Shen QY,Xie D,Zhao QZ,Xu YM

    更新日期:2020-11-01 00:00:00

  • A prevalence study of potentially inappropriate medications use in hospitalized Pakistani elderly.

    abstract:BACKGROUND:Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS:To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the facto...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Mazhar F,Akram S,Malhi SM,Haider N

    更新日期:2018-01-01 00:00:00

  • Predictors of institutionalization in people with dementia: a survey linked with administrative data.

    abstract:BACKGROUND:For people with dementia, moving into a nursing home is usually considered at some point in time. Currently available information on predictors of institutionalization is often based on small sample sizes, not taking competing risks into account, and with inconclusive results for sex. AIMS:We aimed to carry...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Runte R

    更新日期:2018-01-01 00:00:00

  • Changes in person-environmental fit and ADL dependence among older Swedish adults. A 10-year follow-up.

    abstract:BACKGROUND AND AIMS:In order to investigate the relation between personal functional capacity and the physical housing environment during the aging process, the aim of this study was to give a long-term description of person-environmental fit (P-E fit) problems in terms of housing accessibility and ADL dependence among...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Werngren-Elgström M,Carlsson G,Iwarsson S

    更新日期:2008-10-01 00:00:00

  • Health status in the oldest old. Age and sex differences in the Umeå 85+ Study.

    abstract:BACKGROUND AND AIMS:With an increasing population aged 85 years and over, the aim of this study was to describe health status and living conditions in the oldest old and to estimate age and sex differences in a Northern European population. METHODS:A population-based cross-sectional study, The Umeå 85+ Study, was carr...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: von Heideken Wågert P,Gustavsson JM,Lundin-Olsson L,Kallin K,Nygren B,Lundman B,Norberg A,Gustafson Y

    更新日期:2006-04-01 00:00:00