Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

Abstract:

BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using a rat model. METHODS:Rapid resolution liquid chromatography/electrospray ionization quadrupole-time of flight mass spectrometry (RRLC/ESI-Q-TOFMS) was employed to analyze metabolomic profiling of urine samples from aging rats who underwent caloric restriction (CR; n=7) or were provided a normal diet (N; n=8) for 12 weeks time. Multivariate data analysis was performed on the mass data of metabolomic profiles to uncover the differences between the CR and N groups. RESULTS:CR treatment led to manifest metabolic changes in aging rats, and fifteen urinary metabolites including hypoxanthine, hippurate, dimethylglycine and creatinine were significantly different in the rat groups. CONCLUSION:Our study demonstrates the high reliability of the HPLC-based metabolomic approach towards the study of anti-aging effects induced by CR, while the urinary metabolites we identified may become potential biomarkers of aging.

journal_name

Aging Clin Exp Res

authors

Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

doi

10.3275/7519

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

79-84

issue

1

eissn

1594-0667

issn

1720-8319

pii

7519

journal_volume

24

pub_type

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