Abstract：
BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral blood mononuclear cells (PBMC) were isolated and PBMC proliferation and production of IL-6, tumor necrosis factor (TNF)-alpha, and IL-10 in the presence and absence of lipopolysaccharide (LPS) were examined. RESULTS:We found that frail subjects had a significantly lower LPS-induced PBMC proliferation ratio compared with non-frail subjects (2.1+/-0.9 vs 3.11+/-1.9, p<0.03). In addition, frail subjects had higher IL-6 production by PBMC at 48 hours after LPS stimulation (35678+/-15637 vs 25178+/-6342 pg/mL, p<0.03). No significant differences were observed in TNF-alpha, and IL-10 production between groups. CONCLUSIONS:These results suggest that, compared with non-frail controls, frail older adults have both decreased LPS-induced proliferation and increased IL-6 production by PBMC.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Leng SX,Yang H,Walston JDdoi
10.1007/BF03327392subject
Has Abstractpub_date
2004-06-01 00:00:00pages
249-52issue
3eissn
1594-0667issn
1720-8319journal_volume
16pub_type
杂志文章abstract：:The current trend toward an ever increasing aging population forces society to face the problem of how to care for elderly people who are exposed to the risk of so-called "elder abuse," a phenomenon becoming increasingly widespread in Italy, as legislation does not provide a precise juridical definition of "elderly" n...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/7042
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03351076
更新日期：2011-04-01 00:00:00
abstract：:Neoplastic diseases may be complicated by rheumatic diseases or may be occur with them. Dermatomyositis/polymyositis and polymyalgia rheumatica are described as paraneoplastic syndromes. We report a case with proximal muscular weakness as only symptom of colon cancer in the absence of other symptoms and laboratory abn...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0034-9
更新日期：2013-05-01 00:00:00
abstract：AIM:We report 3 cases of spontaneous insufficiency fracture of long bones, to promote awareness of this phenomenon to medical personnel dealing with long-term bedridden patients. METHODS:Cases were analyzed in the light of a literature review. RESULTS:Our patients were all women, who were severely debilitated and had...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324821
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Gender and age effect on brain morphology have been extensively investigated. However, the great variety in methods applied to morphology partly explain the conflicting results of linear patterns of tissue changes and lateral asymmetry in men and women. The aim of the present study was to assess the...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324618
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Interprofessional collaborative practice (ICP) is currently recommended for the delivery of high-quality integrated care for older people. Frailty prevention and management are key elements to be tackled on a multi-professional level. AIM:This study aims to develop a consensus-based European multi-professio...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01455-5
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Higher age is associated with reduced physical capability in the general population. The role of age and gender for physical performance in older adults who exercises regularly is, however, not clear, and there is also a lack of recommendations for outcomes to address physical performance for this population...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01190-x
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Lumbar spinal stenosis (LSS), osteoarthritis (OA) of the knee, and osteoporosis are major locomotive diseases in the elderly population. The aim of this study was to examine the effectiveness of exercise in these three diseases. METHODS:We reviewed the relevant literature, i.e., systematic reviews ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03324783
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some r...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01191-w
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
doi：10.1007/BF03325244
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. AIMS:We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. METHODS:A total of 125 consecutive ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0507-0
更新日期：2016-12-01 00:00:00
abstract：:The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：
更新日期：2011-04-01 00:00:00
abstract：:Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01174-x
更新日期：2019-06-01 00:00:00
abstract：:Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD). Acetylcholinesterase inhibitors (AChEI), the symptomatic therapy in AD, attenuate and delay the cognitive deficit by enhancing cholinergic synapses...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01359-4
更新日期：2019-10-03 00:00:00
abstract：BACKGROUND AND AIMS:Marital and parental role characteristics are important factors in both men and women's health. Most studies to date have either focused on disease specific outcomes or summary measures of self-reported health rather than using functional tests of performance. The goal of this study is to investigat...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325226
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Diagnosis of dementia is often difficult in subjects with low educational level. Our aim was to evaluate the role of functional performance and the possibility of preferring scores of activities of daily living (ADL) and instrumental activities of daily living (IADL) in screening elderly people for ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324675
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:The role played by cognitive reserve for the maintenance of numeracy skills in late adulthood is still not sufficiently explored. AIMS:This study mainly investigated whether cognitive reserve (i.e., vocabulary) mediates on the relationship between non-verbal reasoning and addition and multiplication skills ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01632-x
更新日期：2020-06-18 00:00:00
abstract：BACKGROUND AND AIMS:Hip and knee replacements have become increasingly common in the older population but the prevalence of these procedures and the potential impact on functioning towards the end of life have not been previously described. The aim of this study was to estimate the rates and distribution of hip and kne...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324481
更新日期：2003-02-01 00:00:00
abstract：:Age-related macular disease (AMD) is the leading cause of legal blindness among the elderly in Western nations. The magnitude of the problem will undoubtedly grow, as age is a significant risk factor and the number of people aged 65 and over is projected to increase. The most frequent cause of severe visual loss assoc...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03327409
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324693
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND AND AIMS:In Italy there is a paucity of empirical data on practices concerning end-of-life decisions (ELDs) in geriatrics. We aimed to investigate the frequency and characteristics of ELDs made by Italian physicians and nurses in the geriatric setting. METHODS:In 2009, an anonymous questionnaire was sent to...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8588
更新日期：2012-10-01 00:00:00
abstract：:The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid prof...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0218-y
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Monochromatic pulsating light may have effects on wound healing. In an earlier study of grade II ulcers, there was a tendency toward better healing in the phototherapy group (p=0.06). The present study on patients with grade II ulcers was performed to verify these findings. Data from this study were...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/BF03324734
更新日期：2007-12-01 00:00:00
abstract：:Risk for or established malnutrition is frequent in older adults, accompanied by functional limitations, increased morbidity and mortality. Protein-energy malnutrition is often observed and leads besides other predisposing factors to sarcopenia, the increased loss of muscle mass with aging. Sarcopenia is an integral c...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01170-1
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND AND AIMS:An accurate diagnosis of sarcopenia is required. The aim of this study is to correlate the results of two methods to define sarcopenia using cross sectional body composition data, with actual loss of fat free mass. METHODS:Healthy older subjects (926 females and 381 males aged 70 years or more) and...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324705
更新日期：2007-08-01 00:00:00
abstract：:Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0278-z
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The primary aim of the present study was to examine whether there is an association between blood pressure and the risk of subsequent cognitive decline in the oldest old. Various factors associated with blood pressure and cognitive function were considered. METHODS:The study comprised 599 individua...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325209
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8757
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND AIMS:This pilot study measured the effects of an original low-intensity training program, called "posture-balancing-mobility" (PBM), on muscular function. METHODS:Nine non-disabled, elderly (74.3 +/- 6 years) subjects were trained with the PBM technique for 11 weeks (2 sessions per week). Mean power and...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327350
更新日期：2002-12-01 00:00:00
abstract：:Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0838-0
更新日期：2018-07-01 00:00:00
