Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study.


:The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid profile, nitrite concentration (NO2) and lipid peroxide levels (T-BARS). Also, genomic DNA was extracted from plasma for genotyping NOS3 polymorphisms (-786T>C; 894G>T; and VNTR in intron 4). TS was determined by one-mile walk test and Functional Fitness Test Battery from AAHPERD (TS1-regular TS; TS2-good TS; and TS3-very good TS). BP was not influenced by TS, but NO2 was 15% higher in TS3 (123 ± 27 nM) compared to TS-2 (106 ± 22 nM). No differences were found in plasma NO2 in the haplotype analyses. However, the presence of the C allele (T-786C) and ASP allele (Glu298Asp) was found to enhance the correlation between TS and NO2 levels (r = 0.492 in C/4b/ASP haplotype and r = 0.855 in C/4a/ASP haplotype). This study thus identifies NOS3 polymorphism-dependent sensitivity to the effects of physical training on plasma NO2. Maintenance of good levels of training status, in carriers of C allele for T-786C polymorphism, combined with ASP allele for Glu298Asp polymorphism, may result in an increase in the NO2 plasma concentrations, which may reflect improved NO bioavailability in older adult normotensive individuals.


Aging Clin Exp Res


da Silva RF,Sertório JT,Lacchini R,Trapé AA,Tanus-Santos JE,Rush JW,Amaral SL,Zago AS




Has Abstract


2014-12-01 00:00:00












  • Related factors of cognitive impairment in community-dwelling older adults in Beijing Longitudinal Study of Aging.

    abstract:OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Han R,Tang Z,Ma L

    更新日期:2019-01-01 00:00:00

  • The Charlson Comorbidity and Barthel Index predict length of hospital stay, mortality, cardiovascular mortality and rehospitalization in unselected older patients admitted to the emergency department.

    abstract:BACKGROUND AND AIMS:The Charlson Comorbidity Index (CCI) is the most widely used assessment tool to report the presence of comorbid conditions. The Barthel index (BI) is used to measure performance in activities of daily living. We prospectively investigated the performance of CCI or BI to predict length of hospital st...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bahrmann A,Benner L,Christ M,Bertsch T,Sieber CC,Katus H,Bahrmann P

    更新日期:2019-09-01 00:00:00

  • Focal muscle vibration as a possible intervention to prevent falls in elderly women: a pragmatic randomized controlled trial.

    abstract:BACKGROUNDS:Different and new approaches have been proposed to prevent the risk of falling of elderly people, particularly women. AIMS:This study investigates the possibility that a new protocol based on the focal mechanical muscle vibration may reduce the risk of falling of elderly women. METHODS:A pragmatic randomi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Celletti C,Fattorini L,Camerota F,Ricciardi D,La Torre G,Landi F,Filippi GM

    更新日期:2015-12-01 00:00:00

  • Association between the severity of symptomatic knee osteoarthritis and cumulative metabolic factors.

    abstract:BACKGROUND:The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades. AIMS:To clarify the relationship between cumulative MS factors and symptomatic KOA. METHODS:A cross-sectional survey involving 119 women aged 45-88 years who were...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Yasuda E,Nakamura R,Matsugi R,Goto S,Ikenaga Y,Kuroda K,Nakamura S,Katsuki Y,Katsuki T

    更新日期:2018-05-01 00:00:00

  • The contribution of CNVs to the most common aging-related neurodegenerative diseases.

    abstract::Alzheimer and Parkinson's diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address these complex multifactorial traits, a systems biolog...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Gentile G,La Cognata V,Cavallaro S

    更新日期:2020-02-06 00:00:00

  • Testosterone effect on brain metabolism in elderly patients with Alzheimer's disease: comparing two cases at different disease stages.

    abstract:OBJECTIVE:To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer's disease (AD), respectively. METHODS:We describe the clinical and positron emission tomography (PET) findings for two individuals, one with ea...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Tan RS

    更新日期:2013-06-01 00:00:00

  • Predictors of institutionalization among home-dwelling older Finnish people: a 22-year follow-up study.

    abstract:BACKGROUND:Identification of predictive factors on institutionalization provides the basis for the development and application of preadmission assessment. There is a lack of evidence for predictors of institutionalization for older people. AIMS:To examine the effect of predictive factors on institutionalization in hom...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,收录出版


    authors: Salminen M,Vire J,Viikari L,Vahlberg T,Isoaho H,Lehtonen A,Viitanen M,Arve S,Eloranta S

    更新日期:2017-06-01 00:00:00

  • Predictors of institutionalization in people with dementia: a survey linked with administrative data.

    abstract:BACKGROUND:For people with dementia, moving into a nursing home is usually considered at some point in time. Currently available information on predictors of institutionalization is often based on small sample sizes, not taking competing risks into account, and with inconclusive results for sex. AIMS:We aimed to carry...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Runte R

    更新日期:2018-01-01 00:00:00

  • Is it safe and useful, laparoscopic peritoneal lavage in the treatment of acute diverticulitis of octogenarian patients? A multicenter retroprospective observational study.

    abstract:BACKGROUND:Diverticular disease of the colon also affects older people. Generally, older patients with diverticulitis may be regarded as too risky to undergo surgery. This retroprospective multicentric observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage (LPL) in elderly patients...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Boselli C,Gemini A,Cirocchi R,Grassi V,Avenia S,Polistena A,Sanguinetti A,Pironi D,Santoro A,Tabola R,Burattini MF,Avenia N

    更新日期:2017-02-01 00:00:00

  • Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.

    abstract::Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD). Acetylcholinesterase inhibitors (AChEI), the symptomatic therapy in AD, attenuate and delay the cognitive deficit by enhancing cholinergic synapses...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Benfante R,Di Lascio S,Cardani S,Fornasari D

    更新日期:2019-10-03 00:00:00

  • Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

    abstract:BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

    更新日期:2012-02-01 00:00:00

  • Cardiovascular mortality and C-reactive protein in elderly patients beginning dialysis: reverse epidemiology?

    abstract:BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Millet C,Bosson JL,Pernod G,Wauters JP,Couturier P,Quesada JL,Zaoui P

    更新日期:2011-10-01 00:00:00

  • Acute effects of exergames on cognitive function of institutionalized older persons: a single-blinded, randomized and controlled pilot study.

    abstract:BACKGROUND:Improvements on balance, gait and cognition are some of the benefits of exergames. Few studies have investigated the cognitive effects of exergames in institutionalized older persons. AIMS:To assess the acute effect of a single session of exergames on cognition of institutionalized older persons. METHODS:N...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Monteiro-Junior RS,da Silva Figueiredo LF,Maciel-Pinheiro PT,Abud ELR,Braga AEMM,Barca ML,Engedal K,Nascimento OJM,Deslandes AC,Laks J

    更新日期:2017-06-01 00:00:00

  • Evaluation of an osteoporosis and fall risk intervention program for community-dwelling elderly. A quasi-experimental study of behavioral modifications.

    abstract:BACKGROUND AND AIMS:Osteoporosis and fall fractures are increasing problems amongst the elderly. The aim of this study was to explore whether combined population-based and individual interventions directed at risk factors for osteoporosis and falls result in behavioral changes in an elderly population. METHODS:A quasi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Grahn Kronhed AC,Blomberg C,Löfman O,Timpka T,Möller M

    更新日期:2006-06-01 00:00:00

  • Incidence, risk factors and consequences of falling injuries among the community-dwelling elderly in Shihpai, Taiwan.

    abstract:BACKGROUND AND AIMS:Falls causing injuries among older people and the consequences of those injuries are of increasing concern to public health practitioners. The aims of this study were to determine the incidence, characteristics and risk factors of fall injuries among the community-dwelling elderly in Shihpai, Taiwan...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Chang NT,Yang NP,Chou P

    更新日期:2010-02-01 00:00:00

  • Clinically silent idiopathic Parkinson's disease unmasked by valproate use: a brief report.

    abstract::Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Athauda D,Batley R,Ellis C

    更新日期:2015-06-01 00:00:00

  • Lack of association between appendectomy and Parkinson's disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Accumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson's disease (PD). The appendix contains abundant α-synuclein and lacks a blood-tissue barrier, suggesting that appendectomy might reduce α-synuclein aggregation, and therefore the ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,meta分析,评审


    authors: Lu HT,Shen QY,Xie D,Zhao QZ,Xu YM

    更新日期:2020-11-01 00:00:00

  • Alternative and complementary therapies in osteoarthritis and cartilage repair.

    abstract::Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for thi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Fuggle NR,Cooper C,Oreffo ROC,Price AJ,Kaux JF,Maheu E,Cutolo M,Honvo G,Conaghan PG,Berenbaum F,Branco J,Brandi ML,Cortet B,Veronese N,Kurth AA,Matijevic R,Roth R,Pelletier JP,Martel-Pelletier J,Vlaskovska M,Thoma

    更新日期:2020-04-01 00:00:00

  • The effect of strength training on control of force in older men and women.

    abstract:BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bellew JW

    更新日期:2002-02-01 00:00:00

  • Latin American Adult Immunisation Advocacy Summit: Overcoming regional barriers to adult vaccination.

    abstract::Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Barratt J,Mishra V,Acton M

    更新日期:2019-03-01 00:00:00

  • Neural substrate of a cognitive intervention program using Go game: a positron emission tomography study.

    abstract:BACKGROUND:Influence of cognitive intervention programs on brain activity has not been enough explored. AIMS:The aims of the present study were to clarify changes in brain activity from a cognitive intervention program utilizing the board game "Go" and to examine the relationship between brain activity and the acquisi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Iizuka A,Ishii K,Wagatsuma K,Ishibashi K,Onishi A,Tanaka M,Suzuki H,Awata S,Fujiwara Y

    更新日期:2020-11-01 00:00:00

  • The occurrence of acute myocardial infarction in Italy: a five-year analysis of hospital discharge records.

    abstract:BACKGROUND:The incidence and costs of acute myocardial infarction (AMI) in Europe represent a substantial problem due to population aging. METHODS:Between 2001 and 2005, Italian hospitalization records were examined to evaluate hospital admissions and costs of AMI in adults aged ≥ 45 and in elderly people ≥ 65 or ≥ 75...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Piscitelli P,Iolascon G,Greco M,Marinelli A,Gimigliano F,Gimigliano R,Gisonni P,Giordano A,Migliore A,Granata M,Tarantino U,Brandi ML,Baggiani A,Distante A

    更新日期:2011-02-01 00:00:00

  • Nature diversity and well-being in old age.

    abstract:BACKGROUND:The research aim was to study the associations of nature diversity with quality of life (QoL) and depressive symptoms among older people, and whether physical activity explains the associations. METHODS:Community-dwelling people aged 75-90 years (n = 848) living in Central Finland were interviewed in their ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Rantakokko M,Keskinen KE,Kokko K,Portegijs E

    更新日期:2018-05-01 00:00:00

  • Prevention of the spread of multidrug-resistant organisms in nursing homes.

    abstract::The increase in the aged population led to a global rise in the demand for elderly healthcare services, such as long-term care facilities (LTCFs), nursing homes, residential homes. Unfortunately, the spread of multidrug-resistant organisms (MDROs) in these structures represent an urgent public health threat requiring ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Tinelli M,Tiseo G,Falcone M,ESCMID Study Group for Infections in the Elderly.

    更新日期:2021-01-11 00:00:00

  • Morphometric dual-energy X-ray absorptiometry (MXA) for identification of vertebral fractures.

    abstract::Visual identification of vertebral fractures from spinal radiographs makes use of operator expertise in ruling out non-fracture deformities or normal variants. Morphometric X-ray absorptiometry (MXA) has recently been developed to assess vertebral deformity status quantitatively by dual energy X-ray absorptiometry (DX...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Francucci CM,Romagni P,Fiscaletti P,Caudarella R,Boscaro M

    更新日期:2007-06-01 00:00:00

  • Cognitive performance in community-dwelling older adults with stroke and the contribution of age and diffuse subcortical damage: a population-based study in rural Ecuador (The Atahualpa Project).

    abstract:BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Del Brutto OH,Mera RM,Zambrano M,Lama J

    更新日期:2015-10-01 00:00:00

  • Concordance between clinical and radiographic evaluations of knee osteoarthritis.

    abstract:BACKGROUND:Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS:We aimed to explore the relationship betwee...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Parsons C,Fuggle NR,Edwards MH,Goulston L,Litwic AE,Jagannath D,van der Pas S,Cooper C,Dennison EM,EPOSA Research Group.

    更新日期:2018-01-01 00:00:00

  • Quality indicators in acute stroke care: a prospective observational survey in 13 Italian regions.

    abstract:BACKGROUND AND AIMS:Quality monitoring has great relevance in stroke care. The Project "How to guarantee adherence to effective interventions in stroke care" aimed to estimate adherence to acute-phase guidelines in stroke care in Italy. METHODS:A prospective observational study was performed in 27 hospitals of 13 Ital...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Di Carlo A,Accetta G,Bellan M,Terni G,Lamassa M,Facchini R,Biggeri A,Inzitari D,Ferro S,National Stroke Care Group.

    更新日期:2014-06-01 00:00:00

  • Feasibility of a machine vs free weight strength training program and its effects on physical performance in nursing home residents: a pilot study.

    abstract:BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Johnen B,Schott N

    更新日期:2018-07-01 00:00:00

  • Mild cognitive impairment, degenerative and vascular dementia as predictors of intra-hospital, short- and long-term mortality in the oldest old.

    abstract:BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Zekry D,Herrmann FR,Graf CE,Giannelli S,Michel JP,Gold G,Krause KH

    更新日期:2011-02-01 00:00:00