Abstract:
:The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid profile, nitrite concentration (NO2) and lipid peroxide levels (T-BARS). Also, genomic DNA was extracted from plasma for genotyping NOS3 polymorphisms (-786T>C; 894G>T; and VNTR in intron 4). TS was determined by one-mile walk test and Functional Fitness Test Battery from AAHPERD (TS1-regular TS; TS2-good TS; and TS3-very good TS). BP was not influenced by TS, but NO2 was 15% higher in TS3 (123 ± 27 nM) compared to TS-2 (106 ± 22 nM). No differences were found in plasma NO2 in the haplotype analyses. However, the presence of the C allele (T-786C) and ASP allele (Glu298Asp) was found to enhance the correlation between TS and NO2 levels (r = 0.492 in C/4b/ASP haplotype and r = 0.855 in C/4a/ASP haplotype). This study thus identifies NOS3 polymorphism-dependent sensitivity to the effects of physical training on plasma NO2. Maintenance of good levels of training status, in carriers of C allele for T-786C polymorphism, combined with ASP allele for Glu298Asp polymorphism, may result in an increase in the NO2 plasma concentrations, which may reflect improved NO bioavailability in older adult normotensive individuals.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
da Silva RF,Sertório JT,Lacchini R,Trapé AA,Tanus-Santos JE,Rush JW,Amaral SL,Zago ASdoi
10.1007/s40520-014-0218-ysubject
Has Abstractpub_date
2014-12-01 00:00:00pages
591-8issue
6eissn
1594-0667issn
1720-8319journal_volume
26pub_type
杂志文章abstract:BACKGROUND AND AIMS:Most elderly persons live in developing countries where current geriatric epidemiological data are scarce. We aimed to study major comorbidities, polypharmacy, functional and nutritional status in a Turkish community-dwelling female elderly clinic population. METHODS:Female geriatrics outpatient cl...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0229-8
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0786-8
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Researchers and policy-makers have recognized that quality of life assessments are essential to better understand the benefits of rehabilitation intervention. The purpose of the study was to examine associations between functional status and satisfaction with community participation for persons with...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03337718
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324953
更新日期:2011-02-01 00:00:00
abstract::The increase in the aged population led to a global rise in the demand for elderly healthcare services, such as long-term care facilities (LTCFs), nursing homes, residential homes. Unfortunately, the spread of multidrug-resistant organisms (MDROs) in these structures represent an urgent public health threat requiring ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01746-2
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND AND AIMS:The success of I-131 therapy in geriatric patients who were referred to an endocrinology clinic with toxic nodular goiter and who lived in iodine-deficiency regions was studied. MATERIALS AND METHODS:Patients older than 60 years who received I-131 therapy were included via retrospective data analys...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/8759
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Few studies have explored the activity levels of hospitalised older people and the intra-daily activity patterns in this group have not been described. AIMS:To describe the quantity and daily pattern of physical activity among hospitalised older people using two accelerometers: the ankle-worn StepWatch Acti...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0930-0
更新日期:2018-11-01 00:00:00
abstract::Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01156-z
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Swallowing dysfunction and risk of undernutrition increase the risk of pneumonia, morbidity, and mortality. Short-term care is an unexplored care context, where many older people stay yearly. AIM:This cross-sectional study aimed to describe and analyze the relationship between swallowing dysfunction and ris...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/s40520-018-0944-7
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Fall-induced deaths of elderly people are a major problem. AIM AND METHODS:Using the Official Cause-of-Death Statistics of Finland, we aimed to determine the current trends in the number and age-adjusted incidence (per 100,000 persons) of fall deaths among older Finns by taking into account 50 years or olde...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0898-9
更新日期:2018-09-01 00:00:00
abstract::The assessment of body composition has important applications in the evaluation of nutritional status and estimating potential health risks. Bioelectrical impedance analysis (BIA) is a valid method for the assessment of body composition. BIA is an alternative to more invasive and expensive methods like dual-energy X-r...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-016-0622-6
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND AIMS:The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). METHODS:Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, ge...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324965
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03324513
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Advances such as passive monitoring technology (PMT), which provides holistic supervision of chronically ill and elderly patients, enable and support improved monitoring and observation, thus empowering the growing population of older adults to live more independently while lowering health care expenses. AI...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01323-2
更新日期:2020-07-01 00:00:00
abstract::Visual identification of vertebral fractures from spinal radiographs makes use of operator expertise in ruling out non-fracture deformities or normal variants. Morphometric X-ray absorptiometry (MXA) has recently been developed to assess vertebral deformity status quantitatively by dual energy X-ray absorptiometry (DX...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03325244
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Higher age is associated with reduced physical capability in the general population. The role of age and gender for physical performance in older adults who exercises regularly is, however, not clear, and there is also a lack of recommendations for outcomes to address physical performance for this population...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01190-x
更新日期:2020-02-01 00:00:00
abstract::Thailand is facing a dramatic challenge of how to ensure good health and quality of life for its rapidly increasing number of elderly citizens. The modern health services system established a century ago has a larger proportion of public providers, but only 35-40% share public spending on health. The health services a...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03324448
更新日期:2002-08-01 00:00:00
abstract::Depression is one of the leading causes of suffering in the elderly, but it is often under-diagnosed and under-treated, partly due to the false belief that depression is a common aspect of aging. Depression in the elderly is frequently comorbid with medical illnesses, may often be expressed by somatic complaints, and ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03327382
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Frailty is a public health concern in the ageing population. Little is known about the role of gender in the relationship between frailty and health care utilization in older adults. AIMS:The study aims to examine gender differences in the association between different frailty status and health care utiliza...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01410-4
更新日期:2020-10-01 00:00:00
abstract::Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0278-z
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Proximal femoral fracture is often associated with long-term residual disability. Quadriceps weakness may be a factor in poor outcome. This study aimed to determine whether training of the quadriceps using electrical stimulation (ES) increases leg extensor power and decreases disability in elderly s...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/BF03324749
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Declines in hamstrings and quadriceps maximal and rapid strength are commonly reported as a consequence of aging; however, few studies have investigated the influence of age on maximal and rapid hamstrings to quadriceps (H/Q) strength ratios. This study aimed to examine the effects of age on leg ext...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0734-7
更新日期:2017-12-01 00:00:00
abstract::Celiac disease is a genetic disorder, presenting with malabsorption-related problems because of mucosal damage after ingestion of gluten. The only known effective treatment is a gluten-free diet. Early diagnosis and treatment are essential in preventing complications due to malabsorption. Here we report the case of an...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324644
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The role played by cognitive reserve for the maintenance of numeracy skills in late adulthood is still not sufficiently explored. AIMS:This study mainly investigated whether cognitive reserve (i.e., vocabulary) mediates on the relationship between non-verbal reasoning and addition and multiplication skills ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01632-x
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:We define active aging as a striving for activities as per one's goals, capacities and opportunities. AIM:To test the 1-year counselling intervention effects on active aging. METHODS:In this two-arm single-blinded randomized controlled trial, the intervention group received individually tailored counsellin...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01535-x
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Cutbacks in human resources are putting home care personnel under increasing pressure in their work. Home health care personnel need to know how they can prevent undesirable conditions and support older people towards successful aging. The aim of this ten-year follow-up study was to identify factors...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324832
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring f...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0377-5
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND AIMS:To investigate mortality, determinants of mortality, and time until death among elderly subjects receiving public long-term care. METHODS:This study comprises 626 respondents (age: 65-98 years). Data were collected for two cohorts (2001 and 2002). Cox regression analysis was used to identify determ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324851
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/8757
更新日期:2012-12-01 00:00:00