Abstract：
:We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cytokine genes that we had previously found to be associated with a higher risk of LOAD (IL-10, IL-6, TNF-α). Results showed that all subjects carried one ε4 allele of the APOE gene and those with the earliest age of onset exhibited the AA (-1082) IL-10 and the CC (-174) IL-6 genotypes. The only male had a genetic profile which also included the A (-308) TNF-α allele. These data confirm the role of the APOE gene as genetic risk factor in LOAD, and suggest that the risk of developing AD may be governed by a "susceptibility profile" involving polymorphisms in inflammatory genes.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Abbate C,Arosio B,Cantatore A,Viti N,Giunco F,Bagarolo R,Nicolini P,Gussago C,Ferri E,Casati M,Rossi PD,Casè A,Bergamaschini L,Vergani C,Mari Ddoi
10.1007/s40520-015-0383-7subject
Has Abstractpub_date
2016-10-01 00:00:00pages
991-5issue
5eissn
1594-0667issn
1720-8319pii
10.1007/s40520-015-0383-7journal_volume
28pub_type
杂志文章abstract：BACKGROUND:Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. AIMS:In order to assure broader coverage o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0651-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Aging, cancer and its treatment all contribute to increase the risk of deconditioning and sedentary behaviors. Mixed exercise is recognized to counteract the effects of aging and deconditioning as well as improving physical capacity during cancer treatment in adults. AIMS:To determine the impact of a mixed ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-018-1097-4
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324693
更新日期：2007-06-01 00:00:00
abstract：INTRODUCTION:Using biomarkers to predict mortality in patients with sepsis is important because these patients frequently have high mortality rates and unsatisfactory outcomes. The performance of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and C-reactive protein (CRP) to predict clinical outcomes in elderly s...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01244-0
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND AND AIMS:To assess the incidence and prognostic value of hypoglycemia in hospitalized non-diabetic elderly patients. METHODS:An observational retrospective study, with a 3-year follow-up, was performed in a series of 678 patients aged over 65 years, admitted between January 1 2001 and December 31 2001 to th...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324842
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Adaptation to strength training in very old mobility-limited individuals is not fully characterized. Therefore, the aim of this study was to perform a thorough investigation of the adaptation to a lower body strength training regime in this population, with particular emphasis on the relationship between cha...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-019-01234-2
更新日期：2020-04-01 00:00:00
abstract：:Osseointegration is a term that refers to the formation of a direct interface between an implant and bone without intervening soft tissue. Cementless femoral fixation in total hip arthroplasty is dependent on mechanical and biological factors that affect implant stability and long-term outcome. Osteoporosis leads to m...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0103-0
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND AND AIMS:With an increasing population aged 85 years and over, the aim of this study was to describe health status and living conditions in the oldest old and to estimate age and sex differences in a Northern European population. METHODS:A population-based cross-sectional study, The Umeå 85+ Study, was carr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327426
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND AIMS:External hip protectors have been shown to have a good preventive effect against hip fractures in many studies. However, these studies were carried out either entirely or mostly among older persons living in institutions. The aim of this study was to investigate whether health nurses can, after brie...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324530
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325234
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0786-8
更新日期：2018-04-01 00:00:00
abstract：AIM:The main purpose of the present study was to verify the feasibility of wearable inertial sensors (IMUs) in a clinical setting to screen gait and functional mobility in Italian older persons. In particular, we intended to verify the capability of IMUs to discriminate individuals with and without cognitive impairment...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01715-9
更新日期：2020-09-25 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to develop a Turkish version of the Nottingham Extended Activities of Daily Living Scale (NEADLS) and to assess its reliability and validity. METHODS:Sixty healthy volunteers over 67 years old were included in the study. After translation, the Turkish version of the scale ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325144
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of the present study is to describe the effects of aging on various cognitive domains (global cognitive function, executive function, motor speed) in a population sample of elderly men, and to describe how their age-related changes are influenced by education, depression, or prevalent cerebr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324624
更新日期：2005-10-01 00:00:00
abstract：:Despite strong evidence for the efficacy of integrated systems, securing the participation of health professionals, particularly primary care physicians (PCPs), has proven difficult. Novel approaches are needed to resolve these problems. We developed a model - COPA - that is based on scientific evidence and an origina...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327446
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS:The cognitive functions of 98 elderly patients who were scheduled t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0519-9
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0943-8
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral bl...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327392
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The SarQoL® is a recently developed quality of life questionnaire specific to sarcopenia. AIM:To compare the quality of life (QoL) of subjects identified as sarcopenic with that of non-sarcopenic subjects when using six different operational definitions of sarcopenia. METHODS:Participants of the SarcoPhAge...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0866-9
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01555-7
更新日期：2020-04-16 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to ascertain whether there are gender-related differences in the morphological characteristics of the soleus and tibialis anterior muscles in young adult and old Fischer 344/Brown Norway F1 rats. METHODS:We tested 1) whether there was a gender-related difference between th...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324508
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Cutbacks in human resources are putting home care personnel under increasing pressure in their work. Home health care personnel need to know how they can prevent undesirable conditions and support older people towards successful aging. The aim of this ten-year follow-up study was to identify factors...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324832
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The clinical problems and needs of our oldest old (≥85 years) are often substantially different from those of younger patients, and are arguably different from younger elderly patients (age 65-84). With the increasing number of frail oldest olds residing in Nursing Homes (NH), we aim to identi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0145-3
更新日期：2014-04-01 00:00:00
abstract：:Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, persona...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03324486
更新日期：2003-04-01 00:00:00
abstract：:The occurrence of a given disease in a population is measured by prevalence and incidence. Prevalence reflects the burden of a given disease in a specific population and is calculated as point prevalence or period prevalence. Incidence denotes the number of new cases of a given disease which occur in a cohort of indiv...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03325157
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVES:The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age. METHODS:Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (avera...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-016-0531-8
更新日期：2016-12-01 00:00:00
abstract：:Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324906
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Sagittal spinal alignment is an important determinant for proper spinal function. Alterations in spinal alignment may serve as leading factor for diminished body biomechanics. Although increased age is suggested to be associated with changes in lumbosacral alignment, in turn body posture, this is still a cur...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0274-3
更新日期：2015-06-01 00:00:00
abstract：:Thailand is facing a dramatic challenge of how to ensure good health and quality of life for its rapidly increasing number of elderly citizens. The modern health services system established a century ago has a larger proportion of public providers, but only 35-40% share public spending on health. The health services a...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03324448
更新日期：2002-08-01 00:00:00
abstract：:Senescence of the brain seems to be related to increased levels of free oxygen radical (FOR). FOR may damage macromolecular compounds such as: proteins, lipids, and DNA. In the aging brain, increased FOR levels damage DNA, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA). In DNA they damage single and double strands,...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0004-2
更新日期：2013-04-01 00:00:00
