Abstract：
BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring flow-mediated dilatation (FMD). MATERIALS AND METHODS:The study included 20 cases with wet AMD (Group 1, mean age 65.9 ± 7.2 years) and 24 healthy individuals (Group 2, mean age 62.0 ± 11.9 years). In all cases, a cardiologist assessed the responses of endothelial function by measuring the FMD following brachial artery occlusion. RESULTS:Mean FMD, an indicator of endothelial function was found to be 6.4 ± 2.7 % in Group 1 and 15.6 ± 7.3 % in Group 2 (p < 0.001). There was no significant difference between patient and control groups regarding age, sex, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, ESR and CRP. CONCLUSION:Reduced FMD is present in patients with wet AMD, suggesting that impaired peripheral endothelial function may be involved in its pathogenesis.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Arifoglu HB,Karatepe Hashas AS,Atas M,Sarli B,Ozkose A,Demircan Sdoi
10.1007/s40520-015-0377-5subject
Has Abstractpub_date
2016-10-01 00:00:00pages
853-6issue
5eissn
1594-0667issn
1720-8319pii
10.1007/s40520-015-0377-5journal_volume
28pub_type
杂志文章abstract：BACKGROUND AND AIMS:In Italy there is a paucity of empirical data on practices concerning end-of-life decisions (ELDs) in geriatrics. We aimed to investigate the frequency and characteristics of ELDs made by Italian physicians and nurses in the geriatric setting. METHODS:In 2009, an anonymous questionnaire was sent to...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8588
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Changes in some rhythmometric parameters have been reported in the elderly as a consequence of both structural and neurochemical changes occurring in the central nervous system. Since alterations of lipid and lipoprotein metabolism are directly involved in several age-related disorders, the aim of t...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324422
更新日期：2002-04-01 00:00:00
abstract：:Senescence of the brain seems to be related to increased levels of free oxygen radical (FOR). FOR may damage macromolecular compounds such as: proteins, lipids, and DNA. In the aging brain, increased FOR levels damage DNA, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA). In DNA they damage single and double strands,...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0004-2
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Low total lymphocyte count (TLC) has been found to be a poor prognostic factor in adults affected by heart diseases, malignancy, and renal failure. The aims of this study were to verify if a low TLC was associated with in-hospital mortality in older persons and to evaluate whether this association w...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324858
更新日期：2008-08-01 00:00:00
abstract：:MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-020-01516-0
更新日期：2020-05-01 00:00:00
abstract：AIM:To evaluate the role of balance and gait disorders, comorbidities and laboratory abnormalities in the occurrence of falls in an institutionalized elderly population. METHODS:We made a non-interventional, prospective, observational study in elderly institutionalized people. Comorbidities and information on treatmen...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0304-1
更新日期：2015-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid prof...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0218-y
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0746-3
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Osteoporosis is a common disease in elderly, characterized by poor bone quality as a result of alterations affecting trabecular bone. However, recent studies have described also an important role of alterations of cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0423-3
更新日期：2015-10-01 00:00:00
abstract：:The occurrence of a given disease in a population is measured by prevalence and incidence. Prevalence reflects the burden of a given disease in a specific population and is calculated as point prevalence or period prevalence. Incidence denotes the number of new cases of a given disease which occur in a cohort of indiv...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03325157
更新日期：2012-04-01 00:00:00
abstract：:The aim of the study was to look firstly at the changes that occurred in depressive symptomatology over a 5-year period among originally 75-year-old residents in three Nordic localities: Glostrup in Denmark, Göteborg in Sweden and Jyväskylä in Finland, and secondly, at some selected variables if they predicted depress...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Art-based activities like painting workshops demonstrated health benefits in older individuals living in home care facilities. Few studies examined the effects of painting workshops in geriatric inpatients. AIM:The study aims to examine whether the participation in painting workshops performed in patients a...
journal_title：Aging clinical and experimental research
pub_type： 临床试验,杂志文章
doi：10.1007/s40520-020-01675-0
更新日期：2020-12-01 00:00:00
abstract：:Excess of bone remodeling is still the major pathogenic factor in involutional osteoporosis. This phenomenon is linked to an imbalance between neoformation (by osteoblasts) and resorption (by osteoclasts). Recently, research in drug development is focused on new and more "physiological" approach to balance bone remode...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0086-x
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Although nutritional status plays an important part in the physical performance and disability of older people, this relationship has been little studied in developing countries. AIMS:A study on the effects of nutritional status on the physical performance and functional status of elderly people living in r...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0591-9
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND AND AIMS:The effect of heavy work-related physical loads (WRPL) on low back pain (LBP) and impaired physical function has been studied extensively in active workers but not in pensioners. METHODS:We compared LBP and physical function in post-menopausal pensioners, divided according to their life-long WRPL i...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324899
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-017-0830-8
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01555-7
更新日期：2020-04-16 00:00:00
abstract：BACKGROUND:In spite of a rapidly ageing population, there is a lack of population-based data on mortality among nursing home residents in Southern Europe. AIMS:To assess mortality rates, their determinants, and causes of death in newly admitted nursing home residents in the Veneto region (northeastern Italy). METHODS...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01441-x
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324415
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:To determine the association between the level of nutritional risk and the mortality of hospitalized patients with atrial fibrillation. METHODS:In a prospective cohort study, we included patients hospitalized with atrial fibrillation in an internal medicine department in 2007. We calculated the nutritional r...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01152-3
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND AND AIM:Sarcopenia and sarcopenic obesity (SO) are associated with adverse health outcomes in older people. Data on sarcopenia- and SO-related mortality are insufficient for hospitalized older people. The aim of this study was to evaluate the relationship between sarcopenia, SO and mortality among hospitaliz...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01277-5
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0943-8
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND AIMS:The success of I-131 therapy in geriatric patients who were referred to an endocrinology clinic with toxic nodular goiter and who lived in iodine-deficiency regions was studied. MATERIALS AND METHODS:Patients older than 60 years who received I-131 therapy were included via retrospective data analys...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8759
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Hip fractures (HF) are a major issue worldwide. We aimed at evaluating the practices in delivering care to patients with HF among several Italian Orthogeriatric centers. METHODS:The study took place from February 2016 to July 2018. Seven performance indicators (pre-surgical cognitive assessment, surgery per...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01488-1
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). METHODS:Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, ge...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324965
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to develop a Turkish version of the Nottingham Extended Activities of Daily Living Scale (NEADLS) and to assess its reliability and validity. METHODS:Sixty healthy volunteers over 67 years old were included in the study. After translation, the Turkish version of the scale ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325144
更新日期：2008-10-01 00:00:00
abstract：:We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0383-7
更新日期：2016-10-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for thi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-020-01515-1
更新日期：2020-04-01 00:00:00
abstract：:The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The clinical problems and needs of our oldest old (≥85 years) are often substantially different from those of younger patients, and are arguably different from younger elderly patients (age 65-84). With the increasing number of frail oldest olds residing in Nursing Homes (NH), we aim to identi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0145-3
更新日期：2014-04-01 00:00:00
