Abstract:
BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome of elderly and younger patients hospitalized with AF in a Middle-Eastern country and examine the trends of AF etiologies over a 20-year period. METHODS:A retrospective analysis of a prospective registry of all patients hospitalized with AF in Qatar from 1991 through 2010 was made. Patients were divided into three groups; group 1: patients ≤50 years old, group 2: patients between 51 and 70 years old, and group 3: patients >70 years old. Clinical characteristics, management, and outcomes of AF patients were compared according to age. RESULTS:Between the year 1991 and the end of 2010, a total 3848 consecutive patients were admitted with AF. One thousand three hundred and forty-five patients were ≤50 years, 1759 were between 51 and 70 years and 744 patients were >70 years old. Elderly patients were more likely to have hypertension and chronic renal impairment. There was a higher prevalence of associated coronary artery disease and aortic stenosis in elderly patients with a lower left ventricular ejection fraction than the younger age groups. A lower use of anticoagulation in the elderly group was observed but there was no underuse of other evidence-based medications. The older AF patients had significantly higher in-hospital mortality and stroke rates with no significant changes in mortality trends over the 20 years of study. An increasing trend of the associated acute coronary syndromes, hypertension and diabetes mellitus prevalence was observed in the elderly group. CONCLUSION:Anticoagulation remains underutilized in elderly patients with AF despite proven efficacy and increasing trends of cardiovascular comorbidities. The current study underscores the urgent need for prospective studies to investigate warfarin contraindications, relative warfarin efficacy and bleeding risks in our region to help guide healthcare providers in warfarin prescribing in this frail patient population and consequently reduce the risk of AF-related disabling strokes and mortality.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Salam AM,AlBinali HA,Al-Sulaiti EM,Al-Mulla AW,Singh R,Al Suwaidi Jdoi
10.3275/8757subject
Has Abstractpub_date
2012-12-01 00:00:00pages
682-90issue
6eissn
1594-0667issn
1720-8319pii
8757journal_volume
24pub_type
杂志文章abstract:AIMS:This study aimed at examining whether ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) were independently associated with carotid Intima-media thickness (CIMT) or carotid artery plaque (CAP) in elderly people. METHODS:A cross-sectional analysis was performed in 155 individuals aged over 7...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01415-z
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Muscle strength may decline with age differentially in the upper and lower limbs. This information is difficult to capture through a single measure. The present study therefore aimed to characterize the relative changes in handgrip and lower limb muscle strength with aging by expressing them as a ra...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03325252
更新日期:2012-06-01 00:00:00
abstract::The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The effect of heavy work-related physical loads (WRPL) on low back pain (LBP) and impaired physical function has been studied extensively in active workers but not in pensioners. METHODS:We compared LBP and physical function in post-menopausal pensioners, divided according to their life-long WRPL i...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324899
更新日期:2009-02-01 00:00:00
abstract::Depression is one of the leading causes of suffering in the elderly, but it is often under-diagnosed and under-treated, partly due to the false belief that depression is a common aspect of aging. Depression in the elderly is frequently comorbid with medical illnesses, may often be expressed by somatic complaints, and ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03327382
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Bone structure, geometry and mineral content represent complex traits with a significant heritable component. However, the specific contributing genes have not been unambiguously identified. The aim of the present cross-sectional study was to analyse an association between heel ultrasound measuremen...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324584
更新日期:2005-04-01 00:00:00
abstract:AIM:We report 3 cases of spontaneous insufficiency fracture of long bones, to promote awareness of this phenomenon to medical personnel dealing with long-term bedridden patients. METHODS:Cases were analyzed in the light of a literature review. RESULTS:Our patients were all women, who were severely debilitated and had...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324821
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) and type 2 diabetes, two diseases that contribute considerable morbidity and mortality in middle-age and elderly people, coexist and progress in parallel, leading to the presumption that one may cause the other. However, a causative link has not yet been established. METHODS:This st...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0181-z
更新日期:2014-02-01 00:00:00
abstract::We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.3275/8337
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregu...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/6810
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Gait disorders are common in the elderly populations, and their prevalence increases with age. Abnormal gait has been associated with greater risk for adverse outcomes in older adults, such as immobility and falls, which in turn lead to loss of functional independence and death. AIM:The purpose of this revi...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-015-0420-6
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:It is important to identify the relevant parameters of physical performance to prevent early functional decline and to prolong independent living. The aim of this study is to describe the development of physical performance in a healthy community-dwelling older cohort aged 70+ years using comprehensive asses...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01562-8
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Nursing home institutionalization tends to exacerbate loss of functioning. AIMS:Examine the feasibility and the effect of a psychomotor intervention-a multimodal exercise program promoting simultaneous cognitive and motor stimulation-on the executive (planning ability and selective attention) and physical f...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0803-y
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03324513
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is highly prevalent and increasing in geriatric population. Depression and sleep disorders occur at a higher rate in patients with diabetes compared with controls. AIM:The purpose of this study was to demonstrate whether diabetic complications influence the sleep quality and depressio...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0293-0
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0130-x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIMS:To assess the incidence and prognostic value of hypoglycemia in hospitalized non-diabetic elderly patients. METHODS:An observational retrospective study, with a 3-year follow-up, was performed in a series of 678 patients aged over 65 years, admitted between January 1 2001 and December 31 2001 to th...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324842
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND AIMS:This pilot study measured the effects of an original low-intensity training program, called "posture-balancing-mobility" (PBM), on muscular function. METHODS:Nine non-disabled, elderly (74.3 +/- 6 years) subjects were trained with the PBM technique for 11 weeks (2 sessions per week). Mean power and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327350
更新日期:2002-12-01 00:00:00
abstract::Thailand is facing a dramatic challenge of how to ensure good health and quality of life for its rapidly increasing number of elderly citizens. The modern health services system established a century ago has a larger proportion of public providers, but only 35-40% share public spending on health. The health services a...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03324448
更新日期:2002-08-01 00:00:00
abstract:AIM:To evaluate the role of balance and gait disorders, comorbidities and laboratory abnormalities in the occurrence of falls in an institutionalized elderly population. METHODS:We made a non-interventional, prospective, observational study in elderly institutionalized people. Comorbidities and information on treatmen...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0304-1
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Fast- and usual-paced 400-m walking tests are often used to assess physical fitness or function, respectively, though it is not known how performance converges on these tests. This study aims to determine whether performance on the fast- and usual-paced 400-m walks varies based upon age and physical...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0287-y
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Cutbacks in human resources are putting home care personnel under increasing pressure in their work. Home health care personnel need to know how they can prevent undesirable conditions and support older people towards successful aging. The aim of this ten-year follow-up study was to identify factors...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324832
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND AIMS:To investigate mortality, determinants of mortality, and time until death among elderly subjects receiving public long-term care. METHODS:This study comprises 626 respondents (age: 65-98 years). Data were collected for two cohorts (2001 and 2002). Cox regression analysis was used to identify determ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324851
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01420-2
更新日期:2019-11-22 00:00:00
abstract:BACKGROUND AND AIMS:This study aimed at examining factors related to osteoarthritis (OA) symptom severity in African American and Caucasian veterans (n=202). METHODS:OA symptom severity (lower extremity pain, stiffness, and physical function) was measured by the Western Ontario and McMaster Universities Osteoarthritis...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324608
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Oxidative stress has been considered one of the causes of aging. For this reason, treatments based on antioxidants or those capable of increasing endogenous antioxidant activity have been taken into consideration to delay aging or age-related disease progression. AIM:In this paper, we determine if resveratr...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0366-8
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND/AIM:Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug-drug interactions, prescribing cascades, and potentially inappropriate medication...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01239-x
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0943-8
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cognitive and physical deficits independently raise the risk for negative events in older adults. Less is known about whether their co-occurrence constitutes a distinct risk profile. This study quantifies the association between cognitive impairment, no dementia (CIND), slow walking speed (WS) and their comb...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01297-1
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0746-3
更新日期:2018-01-01 00:00:00