当前位置： SCI文献检索 > AGING CLINICAL AND EXPERIMENTAL RESEARCH期刊下所有文献 > Disability trajectories and mortality in older adults with different cognitive and physical profiles.

Disability trajectories and mortality in older adults with different cognitive and physical profiles.

Abstract：

BACKGROUND:Cognitive and physical deficits independently raise the risk for negative events in older adults. Less is known about whether their co-occurrence constitutes a distinct risk profile. This study quantifies the association between cognitive impairment, no dementia (CIND), slow walking speed (WS) and their combination and disability and mortality. METHODS:We examined 2546 dementia-free people aged ≥ 60 years, part of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) up to 12 years. The following four profiles were created: (1) healthy profile; (2) isolated CIND (scoring 1.5 SD below age-specific means on at least one cognitive domain); (3) isolated slow WS (< 0.8 m/s); (4) CIND+ slow WS. Disability was defined as the sum of impaired activities of daily living and trajectories of disability were derived from mixed-effect linear regression models. Piecewise proportional hazard models were used to estimate mortality rate [hazard ratios (HRs)]. Population attributable risks of death were calculated. RESULTS:Participants with both CIND and slow WS had the worst prognosis, especially in the short-term period. They experienced the steepest increase in disability and five times the mortality rate (HR 5.1; 95% CI 3.5-7.4) of participants free from these conditions. Similar but attenuated results were observed for longer follow-ups. Co-occurring CIND and slow WS accounted for 30% of short-term deaths. CONCLUSIONS:Co-occurring cognitive and physical limitations constitute a distinct risk profile in older people, and account for a large proportion of short-term deaths. Assessing cognitive and physical function could enable early identification of people at high risk for adverse events.

journal_name

Aging Clin Exp Res

journal_title

Aging clinical and experimental research

authors

Grande G,Vetrano DL,Fratiglioni L,Marseglia A,Vanacore N,Laukka EJ,Welmer AK,Rizzuto D

doi

10.1007/s40520-019-01297-1

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1007-1016

issue

6

eissn

1594-0667

issn

1720-8319

pii

10.1007/s40520-019-01297-1

journal_volume

32

pub_type

杂志文章

相关文献

AGING CLINICAL AND EXPERIMENTAL RESEARCH文献大全
  • Comorbidities, polypharmacy, functionality and nutritional status in Turkish community-dwelling female elderly.

    abstract：BACKGROUND AND AIMS:Most elderly persons live in developing countries where current geriatric epidemiological data are scarce. We aimed to study major comorbidities, polypharmacy, functional and nutritional status in a Turkish community-dwelling female elderly clinic population. METHODS:Female geriatrics outpatient cl...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-014-0229-8

    authors： Bahat G,Tufan F,Bahat Z,Tufan A,Aydin Y,Akpinar TS,Nadir S,Erten N,Karan MA

    更新日期：2014-06-01 00:00:00

  • Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

    abstract：BACKGROUND:Physical exercise and nutrition seem to have a key role in the management of hip fracture patients. AIM:To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients. METHODS:In th...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40520-018-1090-y

    authors： Invernizzi M,de Sire A,D'Andrea F,Carrera D,Renò F,Migliaccio S,Iolascon G,Cisari C

    更新日期：2019-10-01 00:00:00

  • The effect of individualized, theory-based counselling intervention on active aging and quality of life among older people (the AGNES intervention study).

    abstract：BACKGROUND:We define active aging as a striving for activities as per one's goals, capacities and opportunities. AIM:To test the 1-year counselling intervention effects on active aging. METHODS:In this two-arm single-blinded randomized controlled trial, the intervention group received individually tailored counsellin...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-020-01535-x

    authors： Rantanen T,Hassandra M,Pynnönen K,Siltanen S,Kokko K,Karavirta L,Kauppinen M,Sipilä S,Saajanaho M,Portegijs E

    更新日期：2020-10-01 00:00:00

  • Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

    abstract：BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.3275/7519

    authors： Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

    更新日期：2012-02-01 00:00:00

  • Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).

    abstract：OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-013-0025-x

    authors： Chen JM,Huang CQ,Ai M,Kuang L

    更新日期：2013-05-01 00:00:00

  • The occurrence of acute myocardial infarction in Italy: a five-year analysis of hospital discharge records.

    abstract：BACKGROUND:The incidence and costs of acute myocardial infarction (AMI) in Europe represent a substantial problem due to population aging. METHODS:Between 2001 and 2005, Italian hospitalization records were examined to evaluate hospital admissions and costs of AMI in adults aged ≥ 45 and in elderly people ≥ 65 or ≥ 75...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03337744

    authors： Piscitelli P,Iolascon G,Greco M,Marinelli A,Gimigliano F,Gimigliano R,Gisonni P,Giordano A,Migliore A,Granata M,Tarantino U,Brandi ML,Baggiani A,Distante A

    更新日期：2011-02-01 00:00:00

  • Acetylcholinesterase inhibitors and depressive symptoms in patients with mild to moderate Alzheimer's disease.

    abstract：BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324693

    authors： Rozzini L,Vicini Chilovi B,Bertoletti E,Trabucchi M,Padovani A

    更新日期：2007-06-01 00:00:00

  • Functional status and satisfaction with community participation in persons with stroke following medical rehabilitation.

    abstract：BACKGROUND AND AIMS:Researchers and policy-makers have recognized that quality of life assessments are essential to better understand the benefits of rehabilitation intervention. The purpose of the study was to examine associations between functional status and satisfaction with community participation for persons with...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03337718

    authors： Ostir GV,Smith PM,Smith D,Ottenbacher KJ

    更新日期：2005-02-01 00:00:00

  • Coordination of trunk and foot acceleration during gait is affected by walking velocity and fall history in elderly adults.

    abstract：BACKGROUND:Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. AIMS:The aim of the current study was to determine the effects of walking at non-preferred speeds on the coordination bet...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-018-1036-4

    authors： Craig JJ,Bruetsch AP,Huisinga JM

    更新日期：2019-07-01 00:00:00

  • PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report.

    abstract：BACKGROUND AND AIMS:Peptydil prolyl cis-trans isomerase (PIN-1), which specifically regulates the conformational changes following phosphorylation of several proteins, targets the inactive hyper-phosphorylated tau on the Thr231-Pro motif and directly restores its biological function. Interestingly, PIN-1 is oxidatively...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324722

    authors： Arosio B,Segat L,Milanese M,Galimberti L,Calabresi C,Zanetti M,Trabattoni D,Annoni G,Crovella S,Vergani C

    更新日期：2007-10-01 00:00:00

  • Association of depression and sleep quality with complications of type 2 diabetes in geriatric patients.

    abstract：BACKGROUND:Diabetes mellitus (DM) is highly prevalent and increasing in geriatric population. Depression and sleep disorders occur at a higher rate in patients with diabetes compared with controls. AIM:The purpose of this study was to demonstrate whether diabetic complications influence the sleep quality and depressio...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-014-0293-0

    authors： Öztürk ZA,Yesil Y,Kuyumcu ME,Savas E,Uygun Ö,Sayıner ZA,Kepekçi Y

    更新日期：2015-08-01 00:00:00

  • Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study.

    abstract：BACKGROUND AND AIMS:Marital and parental role characteristics are important factors in both men and women's health. Most studies to date have either focused on disease specific outcomes or summary measures of self-reported health rather than using functional tests of performance. The goal of this study is to investigat...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03325226

    authors： Guralnik JM,Butterworth S,Patel K,Mishra G,Kuh D

    更新日期：2009-04-01 00:00:00

  • Pattern of use and presenting complaints of older patients visiting an Emergency Department in Italy.

    abstract：BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-013-0112-z

    authors： Salvi F,Mattioli A,Giannini E,Vita D,Morichi V,Fallani M,Dessì-Fulgheri P,Cherubini A

    更新日期：2013-10-01 00:00:00

  • Evaluation of renal function in the elderly, not as easy as it seems: a review.

    abstract：:In the elderly assessment of renal function by glomerular filtration rate estimation is crucial for diagnostic, therapeutic and prognostic purposes. Our aim is to illustrate the different formulas available and their respective advantages and disadvantages. ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-014-0311-2

    authors： Ungar A,Iacomelli I,Giordano A,Roberts AT,Rafanelli M,Marchionni N

    更新日期：2015-08-01 00:00:00

  • Lokomat training in vascular dementia: motor improvement and beyond!

    abstract：:Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-015-0343-2

    authors： Calabrò RS,De Luca R,Leo A,Balletta T,Marra A,Bramanti P

    更新日期：2015-12-01 00:00:00

  • Development of a Japanese version of the SARC-F for diabetic patients: an examination of reliability and validity.

    abstract：BACKGROUND:SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. AIMS:To create a Japanese version of the SARC-F (SARC-F-J), a questionnaire for diabetic patients, and to investigate its reliability and validity. METHODS:This...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-016-0668-5

    authors： Ida S,Murata K,Nakadachi D,Ishihara Y,Imataka K,Uchida A,Monguchi K,Kaneko R,Fujiwara R,Takahashi H

    更新日期：2017-10-01 00:00:00

  • Gender differences and burden of chronic conditions: impact on quality of life among the elderly in Taiwan.

    abstract：BACKGROUND:Multiple chronic conditions affect people's health-related quality of life (QoL) and the distributions of the conditions may differ between genders. Our goal was to examine gender differences in chronic conditions and QoL among community-living elderly in Taiwan and to examine whether differences in QoL betw...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-018-1099-2

    authors： Yu T,Enkh-Amgalan N,Zorigt G,Hsu YJ,Chen HJ,Yang HY

    更新日期：2019-11-01 00:00:00

  • The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health.

    abstract：:Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-019-01174-x

    authors： Veronese N,Reginster JY

    更新日期：2019-06-01 00:00:00

  • Incidence and predictors of multimorbidity among a multiethnic population in Malaysia: a community-based longitudinal study.

    abstract：BACKGROUND:Multimorbidity in older adults needs to be assessed as it is a risk factor for disability, cognitive decline, and mortality. AIMS:A community-based longitudinal study was performed to determine the incidence and to identify possible predictors of multimorbidity among multiethnic older adults population in M...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-018-1007-9

    authors： Hussin NM,Shahar S,Din NC,Singh DKA,Chin AV,Razali R,Omar MA

    更新日期：2019-02-01 00:00:00

  • Assessing competence at a higher level among older adults: development of the Japan Science and Technology Agency Index of Competence (JST-IC).

    abstract：BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-017-0786-8

    authors： Iwasa H,Masui Y,Inagaki H,Yoshida Y,Shimada H,Otsuka R,Kikuchi K,Nonaka K,Yoshida H,Yoshida H,Suzuki T

    更新日期：2018-04-01 00:00:00

  • Economic evaluation of passive monitoring technology for seniors.

    abstract：BACKGROUND:Advances such as passive monitoring technology (PMT), which provides holistic supervision of chronically ill and elderly patients, enable and support improved monitoring and observation, thus empowering the growing population of older adults to live more independently while lowering health care expenses. AI...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-019-01323-2

    authors： Schneider JE,Cooper J,Scheibling C,Parikh A

    更新日期：2020-07-01 00:00:00

  • In-hospital elderly mortality and associated factors in 12 Italian acute medical units: findings from an exploratory longitudinal study.

    abstract：BACKGROUND:Given the progressive demographic ageing of the population and the National Health System reforms affecting care at the bedside, a periodic re-evaluation of in-hospital mortality rates and associated factors is recommended. AIMS:To describe the occurrence of in-hospital mortality among patients admitted to ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40520-016-0576-8

    authors： Ambrosi E,De Togni S,Guarnier A,Barelli P,Zambiasi P,Allegrini E,Bazoli L,Casson P,Marin M,Padovan M,Picogna M,Taddia P,Salmaso D,Chiari P,Frison T,Marognolli O,Canzan F,Saiani L,Palese A

    更新日期：2017-06-01 00:00:00

  • Systemic endothelial function in cases with wet-type age-related macular degeneration.

    abstract：BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring f...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-015-0377-5

    authors： Arifoglu HB,Karatepe Hashas AS,Atas M,Sarli B,Ozkose A,Demircan S

    更新日期：2016-10-01 00:00:00

  • Left ventricular hypertrophy and blood pressure as predictors of cognitive decline in old age.

    abstract：BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324544

    authors： Kähönen-Väre M,Brunni-Hakala S,Lindroos M,Pitkala K,Strandberg T,Tilvis R

    更新日期：2004-04-01 00:00:00

  • Nutrition, osteoarthritis and cartilage metabolism.

    abstract：BACKGROUND:Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some r...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-019-01191-w

    authors： Messina OD,Vidal Wilman M,Vidal Neira LF

    更新日期：2019-06-01 00:00:00

  • 79-year-old post-menopausal woman with humerus fracture during teriparatide treatment.

    abstract：:The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：

    authors： Resmini G,Iolascon G

    更新日期：2007-08-01 00:00:00

  • Malnutrition and sarcopenia.

    abstract：:Risk for or established malnutrition is frequent in older adults, accompanied by functional limitations, increased morbidity and mortality. Protein-energy malnutrition is often observed and leads besides other predisposing factors to sarcopenia, the increased loss of muscle mass with aging. Sarcopenia is an integral c...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-019-01170-1

    authors： Sieber CC

    更新日期：2019-06-01 00:00:00

  • Mortality among elderly receiving long-term care: a longitudinal cohort study.

    abstract：BACKGROUND AND AIMS:To investigate mortality, determinants of mortality, and time until death among elderly subjects receiving public long-term care. METHODS:This study comprises 626 respondents (age: 65-98 years). Data were collected for two cohorts (2001 and 2002). Cox regression analysis was used to identify determ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324851

    authors： Jakobsson U,Hallberg IR

    更新日期：2006-12-01 00:00:00

  • Low systolic blood pressure is associated with impaired cognitive function in the oldest old: longitudinal observations in a population-based sample 80 years and older.

    abstract：BACKGROUND AND AIMS:The primary aim of the present study was to examine whether there is an association between blood pressure and the risk of subsequent cognitive decline in the oldest old. Various factors associated with blood pressure and cognitive function were considered. METHODS:The study comprised 599 individua...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03325209

    authors： Nilsson SE,Read S,Berg S,Johansson B,Melander A,Lindblad U

    更新日期：2007-02-01 00:00:00

  • Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:To evaluate the effect of nutrition combined physical exercise interventions on age-related cognitive decline by a systematic review and meta-analysis. METHODS:We searched 9 databases, including PubMed, EMbase, The Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure (CNK...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-020-01730-w

    authors： Liu T,Li N,Hou Z,Liu L,Gao L,Wang L,Tan J

    更新日期：2020-10-14 00:00:00