Abstract：
BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregulation of the overall arterial baroreflex response. We examined the differences in arterial stiffness and baroreflex function in older adults at high cardiovascular risk (advanced age, Type 2 diabetes, hypertension and hyperlipidemia) with and without CSH. METHODS:Forty-three older adults (mean age 71.4+/-0.7) with Type 2 diabetes, hyperlipidemia and hypertension were recruited. After resting supine for 45 minutes prior to the start of data collection, each subject had arterial stiffness measured by pulse wave velocity (PWV, Complior SD), followed by spontaneous baroreflex measures (Baroreflex sensitivity, BRS) and CSM. RESULTS:Of the 43 subjects tested, 10 subjects met the criteria for CSH (8 pure vasodepressor and 2 mixed CSH). CSH subjects had higher measures of arterial stiffness when compared to normal subjects for both radial PWV (11.5+/-0.6 vs 9.6+/-0.4 m/s, p=0.043) and femoral PWV (13.4+/-0.9 vs 11.0+/-0.5 m/s, p=0.036). The CSH group demonstrated significantly lower BRS as compared to the normal group (BRS, 6.73+/-0.58 vs 10.41+/-0.85 ms/mmHg, p=0.038). These results were unchanged when the analysis was repeated with only the VD subjects. CONCLUSIONS:Older adults with CSH have higher arterial stiffness and reduced arterial baroreflex sensitivity. There was no evidence to support upregulation of the arterial baroreflex in patients with CSH.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Madden KM,Lockhart C,Khan Kdoi
10.3275/6810subject
Has Abstractpub_date
2010-02-01 00:00:00pages
36-41issue
1eissn
1594-0667issn
1720-8319pii
6810journal_volume
22pub_type
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324481
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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