Abstract：
BACKGROUND/AIM:Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug-drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults. METHODS:Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients' records according to Beers 2012 criteria. RESULTS:Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25-7.27, p < 0.001), malnutrition (OR 2.69, 95% CI 1.52-4.76, p = 0.001), depression (OR 2.61, 95% CI 1.7-3.95, p < 0.001), presence of fall in the previous year (OR 2.24, 95% CI 1.51-3.32, p < 0.001), and dementia (OR 1.69, 95% CI 1.08-2.65, p = 0.021) were independently associated with the use of PIM. DISCUSSION/CONCLUSIONS:The results of our study suggest that PIM use is independently associated with presence of polypharmacy, malnutrition, depression, falls and dementia in older outpatients. Identifying the association of inappropriate medication use with common geriatric syndromes in older people can help to prevent, delay, and reduce PIM use and related adverse health outcomes.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Kucukdagli P,Bahat G,Bay I,Kilic C,Oren MM,Turkmen BO,Karan MAdoi
10.1007/s40520-019-01239-xsubject
Has Abstractpub_date
2020-04-01 00:00:00pages
681-687issue
4eissn
1594-0667issn
1720-8319pii
10.1007/s40520-019-01239-xjournal_volume
32pub_type
杂志文章abstract：BACKGROUND:Nursing home institutionalization tends to exacerbate loss of functioning. AIMS:Examine the feasibility and the effect of a psychomotor intervention-a multimodal exercise program promoting simultaneous cognitive and motor stimulation-on the executive (planning ability and selective attention) and physical f...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0803-y
更新日期：2018-05-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03324783
更新日期：2010-04-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324818
更新日期：2010-02-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-016-0622-6
更新日期：2017-08-01 00:00:00
abstract：:Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324906
更新日期：2009-06-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/BF03324921
更新日期：2009-08-01 00:00:00
abstract：INTRODUCTION:Syphilis is a systemic human disease which is caused by infection with the spirochete Treponema pallidum. It is spread worldwide, and there has recently been an increase in its incidence. Neurosyphilis (NS) can have a variety of presentations; meningovascular NS is a specific affection of the Treponema whi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1052-4
更新日期：2019-08-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0793-9
更新日期：2017-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0227-x
更新日期：2014-12-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,meta分析
doi：10.1007/s40520-018-0928-7
更新日期：2018-12-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0293-0
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Marital and parental role characteristics are important factors in both men and women's health. Most studies to date have either focused on disease specific outcomes or summary measures of self-reported health rather than using functional tests of performance. The goal of this study is to investigat...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325226
更新日期：2009-04-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0847-z
更新日期：2018-01-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0606-6
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:In the last decade, there has been a rapid increase in the number of elderly patients referred for cardiac surgery. Recent studies have identified risk factors for prolonged intensive care unit (ICU) stay in cardiac surgery patients. The aims of this study was to evaluate pre-operative risk factors for ICU s...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8521
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. AIMS:To create a Japanese version of the SARC-F (SARC-F-J), a questionnaire for diabetic patients, and to investigate its reliability and validity. METHODS:This...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0668-5
更新日期：2017-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-014-0311-2
更新日期：2015-08-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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更新日期：2019-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03327382
更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s40520-020-01665-2
更新日期：2020-09-08 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01703-z
更新日期：2020-09-15 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327405
更新日期：2004-12-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1099-2
更新日期：2019-11-01 00:00:00
abstract：:This case report concerns an elderly woman referred with a 6-month history of rising and falling fever in the range 38-40°C. She was examined repeatedly by her family doctor and given various antibiotic treatments before being hospitalized in our geriatric unit. Laboratory tests and microbiological studies led to a di...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8179
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0130-x
更新日期：2013-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,收录出版
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更新日期：2017-06-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0808-6
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Postoperative cognitive dysfunction (POCD) is a common complication after orthopedic surgery, which is not conducive to the prognosis of the elderly. AIMS:We performed this study to investigate the effects of oxycodone applied for patient-controlled intravenous analgesia (PCIA) on postoperative cognitive fu...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-019-01202-w
更新日期：2020-02-01 00:00:00
