Abstract：
:Depression is one of the leading causes of suffering in the elderly, but it is often under-diagnosed and under-treated, partly due to the false belief that depression is a common aspect of aging. Depression in the elderly is frequently comorbid with medical illnesses, may often be expressed by somatic complaints, and may be a risk factor for other diseases such as dementia and coronary artery disease. Depression decreases the quality of life and increases disability and the risk of mortality, also due to suicide. Although several effective antidepressant drugs are available, with a favorable therapeutic index, non-pharmacological treatments, such as psychotherapy and exercise, should receive greater attention, since combination therapy is probably more effective.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Mecocci P,Cherubini A,Mariani E,Ruggiero C,Senin Udoi
10.1007/BF03327382subject
Has Abstractpub_date
2004-06-01 00:00:00pages
176-89issue
3eissn
1594-0667issn
1720-8319journal_volume
16pub_type
杂志文章,评审abstract：AIM:To evaluate the role of balance and gait disorders, comorbidities and laboratory abnormalities in the occurrence of falls in an institutionalized elderly population. METHODS:We made a non-interventional, prospective, observational study in elderly institutionalized people. Comorbidities and information on treatmen...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0304-1
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Malnutrition and poor physical performance are both conditions that increase in prevalence with age; however, their interrelation in a clinically relevant population has not been thoroughly studied. AIMS:This study aimed to determine the strength of the association between malnutrition and measures of both ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01295-3
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8757
更新日期：2012-12-01 00:00:00
abstract：:We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.3275/8337
更新日期：2012-10-01 00:00:00
abstract：:In severe osteoporosis with recent vertebral compression fracture, drug treatment with anabolic agent in the first 18 months can stimulate the healing process and reduce the rate of progression, preventing new fractures and improving the quality of life of the patient. The sequential therapy with bisphosphonates for a...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND AND AIMS:An accurate diagnosis of sarcopenia is required. The aim of this study is to correlate the results of two methods to define sarcopenia using cross sectional body composition data, with actual loss of fat free mass. METHODS:Healthy older subjects (926 females and 381 males aged 70 years or more) and...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324705
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Sagittal spinal alignment is an important determinant for proper spinal function. Alterations in spinal alignment may serve as leading factor for diminished body biomechanics. Although increased age is suggested to be associated with changes in lumbosacral alignment, in turn body posture, this is still a cur...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0274-3
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer's disease (AD), respectively. METHODS:We describe the clinical and positron emission tomography (PET) findings for two individuals, one with ea...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0049-2
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND AIMS:To evaluate the effect of interdisciplinary outpatient geriatrics on the use, cost, and quality of health services in a fee-for-service (FFS) environment of two networks of primary care clinics operated by a not-for-profit provider organization in Dallas County, Texas. METHODS:The Senior Health Net...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324884
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Osteoporosis is a common disease in elderly, characterized by poor bone quality as a result of alterations affecting trabecular bone. However, recent studies have described also an important role of alterations of cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0423-3
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND AND AIMS:There is no conclusive evidence that hospital fall prevention programs can reduce the number of falls. We aimed to investigate the effect of a targeted individualized falls prevention program in a geriatric rehabilitation hospital. METHODS:This was a two-stage cluster-controlled trial carried out i...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-015-0330-7
更新日期：2015-10-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for thi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-020-01515-1
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. AIMS:In order to assure broader coverage o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-016-0651-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND AND AIMS:In order to investigate the relation between personal functional capacity and the physical housing environment during the aging process, the aim of this study was to give a long-term description of person-environmental fit (P-E fit) problems in terms of housing accessibility and ADL dependence among...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325154
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324415
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0025-x
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Glycemic control in geriatric patients with type 2 diabetes (T2DM) remains clinically challenging. The objective of this study was to compare the safety and efficacy of insulin lispro in patients C65 years (geriatric) to those\65 years (non-geriatric), using a metaanalysis of randomized controlled c...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,meta分析
doi：10.1007/s40520-013-0125-7
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:It is important to identify the relevant parameters of physical performance to prevent early functional decline and to prolong independent living. The aim of this study is to describe the development of physical performance in a healthy community-dwelling older cohort aged 70+ years using comprehensive asses...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01562-8
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:It is unclear whether motor-cognitive dual tasks predict cognitive decline better than either motor or cognitive tasks alone. AIMS:To examine the utility of the novel motor-cognitive dual-task test [Stepping Trail Making Test (S-TMT)], as a predictor of cognitive decline, and compare its predictive performa...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01714-w
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND AND AIMS:Whether or not there has been a "compression of morbidity" in older ages has been vividly debated during the last decades. Previous studies have found indications of both improved and deteriorated health among elderly persons. Few studies have analyzed how changes in health indicators are influenced...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324463
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND/AIM:Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug-drug interactions, prescribing cascades, and potentially inappropriate medication...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-019-01239-x
更新日期：2020-04-01 00:00:00
abstract：:Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, persona...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03324486
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:While most fractures are caused by falls, not all falls result in fractures. Risk factors for falls are well established, but only weak associations have been demonstrated for risk factors for fractures. Conflicting results on the implication of bone mineral density (BMD) suggest that other risk factors shou...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0992-z
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND AND AIMS:This pilot study measured the effects of an original low-intensity training program, called "posture-balancing-mobility" (PBM), on muscular function. METHODS:Nine non-disabled, elderly (74.3 +/- 6 years) subjects were trained with the PBM technique for 11 weeks (2 sessions per week). Mean power and...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327350
更新日期：2002-12-01 00:00:00
abstract：:Physical frailty (PF) and sarcopenia are major health issues in geriatric populations, given their high prevalence and association with several adverse outcomes. Nevertheless, the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation. Existing definitional ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-016-0708-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) is highly prevalent and increasing in geriatric population. Depression and sleep disorders occur at a higher rate in patients with diabetes compared with controls. AIM:The purpose of this study was to demonstrate whether diabetic complications influence the sleep quality and depressio...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0293-0
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0130-x
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some r...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01191-w
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Researchers and policy-makers have recognized that quality of life assessments are essential to better understand the benefits of rehabilitation intervention. The purpose of the study was to examine associations between functional status and satisfaction with community participation for persons with...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03337718
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03351076
更新日期：2011-04-01 00:00:00
