Efficacy and safety of insulin lispro in geriatric patients with type 2 diabetes: a retrospective analysis of seven randomized controlled clinical trials.


BACKGROUND AND AIMS:Glycemic control in geriatric patients with type 2 diabetes (T2DM) remains clinically challenging. The objective of this study was to compare the safety and efficacy of insulin lispro in patients C65 years (geriatric) to those\65 years (non-geriatric), using a metaanalysis of randomized controlled clinical trials (RCT). METHODS:This is a retrospective analysis of predefined endpoints from an integrated database of seven RCTs of T2DM patients treated with insulin lispro. The primary efficacy measure tested the non-inferiority of insulin lispro (geriatric vs. non-geriatric; non-inferiority margin 0.4 %) in terms of hemoglobin A1c (HbA1c) change from baseline to Month 3 (N = 1,525), with change from baseline to Month 6 as a supportive analysis (N = 885). Changes in HbA1c from baseline were evaluated with an analysis of covariance model. Secondary measures included incidence and rate of hypoglycemia, and incidence of cardiovascular events. RESULTS:Mean change in HbA1c from baseline to Month 3 was similar for geriatric (-0.97 %) and non-geriatric patients (-1.05 %); least-square (LS) mean difference (95 % CI) was 0.02 % (-0.11, 0.15 %; p = 0.756). Similar results were observed in patients treated up to Month 6; LS mean difference (95 % CI) was 0.07 % (-0.12, 0.26 %; p = 0.490). Decrease in HbA1c from baseline to Months 3 and 6 was non-inferior in geriatric compared with non-geriatric patients. There were no significant differences in the incidence and the rate of hypoglycemia, incidence of cardiovascular events, or other serious adverse events including malignancy, post-baseline between the two cohorts. CONCLUSION:Key measures of efficacy and safety in geriatric patients with T2DM were not significantly different from non-geriatric patients when utilizing insulin lispro. Insulin lispro may be considered a safe and efficacious therapeutic option for the management of T2DM in geriatric patients.


Aging Clin Exp Res


Curtis BH,Rees TM,Gaskins KA,Sierra-Johnson J,Liu R,Jiang HH,Holcombe JH




Has Abstract


2014-02-01 00:00:00












  • Nordic walking in the second half of life.

    abstract:OBJECTIVES:The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age. METHODS:Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (avera...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Skórkowska-Telichowska K,Kropielnicka K,Bulińska K,Pilch U,Woźniewski M,Szuba A,Jasiński R

    更新日期:2016-12-01 00:00:00

  • Injection of β-amyloid into the hippocampus induces metabolic disturbances and involuntary weight loss which may be early indicators of Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease (AD) and type 2 diabetes, two diseases that contribute considerable morbidity and mortality in middle-age and elderly people, coexist and progress in parallel, leading to the presumption that one may cause the other. However, a causative link has not yet been established. METHODS:This st...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: James D,Kang S,Park S

    更新日期:2014-02-01 00:00:00

  • Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment.

    abstract:BACKGROUND AND AIMS:One of the factors playing a role in both the aging process and the etiopathogenesis of primary hypertension is oxidative stress. The purpose of this work was to estimate the production of nitric oxide (NO), oxidase activity of ceruloplasmin (Cp) and level of malondialdehyde (MDA), the end-product o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Kedziora-Kornatowska K,Kornatowski T,Bartosz G,Pawluk H,Czuczejko J,Kedziora J,Szadujkis-Szadurski L

    更新日期:2006-02-01 00:00:00

  • Cellular and molecular mechanisms of new onset seizure generation.

    abstract::New onset epilepsy and seizures are common neurological disorders in aged people, second only to stroke and dementia. They are frequently related to other pathological conditions including stroke, trauma, tumors and neurological diseases whereas in about one-third of cases the origin is unknown. Besides the origin, th...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Losi G,Gomez-Gonzalo M,Zonta M,Chiavegato A,Carmignoto G

    更新日期:2019-11-15 00:00:00

  • Complications due to late diagnosis of celiac disease with co-existing plasma cell dyscrasia in an elderly patient.

    abstract::Celiac disease is a genetic disorder, presenting with malabsorption-related problems because of mucosal damage after ingestion of gluten. The only known effective treatment is a gluten-free diet. Early diagnosis and treatment are essential in preventing complications due to malabsorption. Here we report the case of an...

    journal_title:Aging clinical and experimental research

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    authors: Cankurtaran M,Ulger Z,Doğan S,Balam Yavuz B,Halil M,Güllü I,Gedikoğlu G,Anioğul S

    更新日期:2006-02-01 00:00:00

  • Acetylcholinesterase inhibitors and depressive symptoms in patients with mild to moderate Alzheimer's disease.

    abstract:BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Rozzini L,Vicini Chilovi B,Bertoletti E,Trabucchi M,Padovani A

    更新日期:2007-06-01 00:00:00

  • Three-year National report from the Gruppo Italiano di Ortogeriatria (GIOG) in the management of hip-fractured patients.

    abstract:BACKGROUND:Hip fractures (HF) are a major issue worldwide. We aimed at evaluating the practices in delivering care to patients with HF among several Italian Orthogeriatric centers. METHODS:The study took place from February 2016 to July 2018. Seven performance indicators (pre-surgical cognitive assessment, surgery per...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Ferrara MC,Andreano A,Tassistro E,Rapazzini P,Zurlo A,Volpato S,Mussi C,Corsi M,Lunardelli ML,Martini E,Castoldi G,De Filippi F,Pizzonia M,Monacelli F,Barone A,Pilotto A,March A,Ungar A,Capelli R,Galmarini V,Franz

    更新日期:2020-07-01 00:00:00

  • T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?

    abstract::Dysfunctional T-cell immunity contributes to susceptibility to infectious disease in the elderly. A characteristic feature of this "immunosenescence" is the predominance of clonal expansions of CD8 cells and decreased diversity of the T-cell antigen receptor repertoire. Lifelong chronic antigenic stress commonly cause...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Pawelec G,Gouttefangeas C

    更新日期:2006-04-01 00:00:00

  • In-hospital elderly mortality and associated factors in 12 Italian acute medical units: findings from an exploratory longitudinal study.

    abstract:BACKGROUND:Given the progressive demographic ageing of the population and the National Health System reforms affecting care at the bedside, a periodic re-evaluation of in-hospital mortality rates and associated factors is recommended. AIMS:To describe the occurrence of in-hospital mortality among patients admitted to ...

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    authors: Ambrosi E,De Togni S,Guarnier A,Barelli P,Zambiasi P,Allegrini E,Bazoli L,Casson P,Marin M,Padovan M,Picogna M,Taddia P,Salmaso D,Chiari P,Frison T,Marognolli O,Canzan F,Saiani L,Palese A

    更新日期:2017-06-01 00:00:00

  • Pattern of use and presenting complaints of older patients visiting an Emergency Department in Italy.

    abstract:BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Salvi F,Mattioli A,Giannini E,Vita D,Morichi V,Fallani M,Dessì-Fulgheri P,Cherubini A

    更新日期:2013-10-01 00:00:00

  • The application of the palliative prognostic index in predicting the life expectancy of patients in palliative care: a systematic review and meta-analysis.

    abstract:BACKGROUND:The palliative prognostic index (PPI) is a commonly used tool to predict the life expectancy in palliative care patients. However, there is no universal cutoff, and the accuracy of different cutoffs varies. Therefore, we conducted this meta-analysis to explore the validity and accuracy of different PPI score...

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    pub_type: 杂志文章,meta分析


    authors: Liu Y,Su L,Wang Y,Liu S,Dong B

    更新日期:2018-12-01 00:00:00

  • The incidence of fragility fractures in Italy.

    abstract::Osteoporosis can significantly impact on the risk of developing a fracture. Thus, fragility fractures represent a challenge for health professionals and decision makers of the twenty-first century. The aim of this work is to review the literature concerning osteoporotic fractures in Italy in terms of incidence, rate o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Ratti C,Vulcano E,La Barbera G,Canton G,Murena L,Cherubino P

    更新日期:2013-10-01 00:00:00

  • Measurement of lean body mass using bioelectrical impedance analysis: a consideration of the pros and cons.

    abstract::The assessment of body composition has important applications in the evaluation of nutritional status and estimating potential health risks. Bioelectrical impedance analysis (BIA) is a valid method for the assessment of body composition. BIA is an alternative to more invasive and expensive methods like dual-energy X-r...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Sergi G,De Rui M,Stubbs B,Veronese N,Manzato E

    更新日期:2017-08-01 00:00:00

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    abstract::Physical frailty (PF) and sarcopenia are major health issues in geriatric populations, given their high prevalence and association with several adverse outcomes. Nevertheless, the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation. Existing definitional ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Calvani R,Marini F,Cesari M,Tosato M,Picca A,Anker SD,von Haehling S,Miller RR,Bernabei R,Landi F,Marzetti E,SPRINTT Consortium.

    更新日期:2017-02-01 00:00:00

  • Old age as an "alternative" to illness: gerontological and medico-legal aspects.

    abstract::The current trend toward an ever increasing aging population forces society to face the problem of how to care for elderly people who are exposed to the risk of so-called "elder abuse," a phenomenon becoming increasingly widespread in Italy, as legislation does not provide a precise juridical definition of "elderly" n...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Molinelli A,Viale L,Landolfa MC,De Stefano F

    更新日期:2011-04-01 00:00:00

  • European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS).

    abstract:BACKGROUND:Interprofessional collaborative practice (ICP) is currently recommended for the delivery of high-quality integrated care for older people. Frailty prevention and management are key elements to be tackled on a multi-professional level. AIM:This study aims to develop a consensus-based European multi-professio...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Roller-Wirnsberger R,Lindner S,Liew A,O'Caoimh R,Koula ML,Moody D,Espinosa JM,van Durme T,Dimitrov P,Benjak T,Nicolaidou E,Hammar T,Vanhecke E,Junius-Walker U,Csizmadia P,Galluzzo L,Macijauskienė J,Salem M,Rietman L,

    更新日期:2020-04-01 00:00:00

  • Acetabular fragility fractures in elderly patients.

    abstract::The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: D'Imporzano M,Liuni FM,Tarantino U

    更新日期:2011-04-01 00:00:00

  • Comorbidities, polypharmacy, functionality and nutritional status in Turkish community-dwelling female elderly.

    abstract:BACKGROUND AND AIMS:Most elderly persons live in developing countries where current geriatric epidemiological data are scarce. We aimed to study major comorbidities, polypharmacy, functional and nutritional status in a Turkish community-dwelling female elderly clinic population. METHODS:Female geriatrics outpatient cl...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bahat G,Tufan F,Bahat Z,Tufan A,Aydin Y,Akpinar TS,Nadir S,Erten N,Karan MA

    更新日期:2014-06-01 00:00:00

  • Plasma nitrite response in older women to a physical function test.

    abstract:BACKGROUND AND AIMS:Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a wi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Dobrosielski DA,Presley T,Perlegas A,Marsh AP,Kim-Shapiro D,Rejeski WJ

    更新日期:2010-10-01 00:00:00

  • Association with and predictive capacity of self-perceived risk of falling in recurrent falls in older people: a prospective study.

    abstract:OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Gálvez-Barrón C,Sanguino MJ,Narvaiza L,Cavestany F,Collado I,Macho O,Dapena MD,Rodríguez-Molinero A

    更新日期:2013-10-01 00:00:00

  • Gender differences and burden of chronic conditions: impact on quality of life among the elderly in Taiwan.

    abstract:BACKGROUND:Multiple chronic conditions affect people's health-related quality of life (QoL) and the distributions of the conditions may differ between genders. Our goal was to examine gender differences in chronic conditions and QoL among community-living elderly in Taiwan and to examine whether differences in QoL betw...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Yu T,Enkh-Amgalan N,Zorigt G,Hsu YJ,Chen HJ,Yang HY

    更新日期:2019-11-01 00:00:00

  • Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging.

    abstract:BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Viidik A,Skalicky M

    更新日期:2003-12-01 00:00:00

  • Minimizing comprehensive geriatric assessment to identify deterioration of physical performance in a healthy community-dwelling older cohort: longitudinal data of the AEQUIPA Versa study.

    abstract:BACKGROUND:It is important to identify the relevant parameters of physical performance to prevent early functional decline and to prolong independent living. The aim of this study is to describe the development of physical performance in a healthy community-dwelling older cohort aged 70+ years using comprehensive asses...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Diekmann R,Hellmers S,Elgert L,Fudickar S,Heinks A,Lau S,Bauer JM,Zieschang T,Hein A

    更新日期:2020-05-01 00:00:00

  • The role of cognitive reserve as mediator for addition and multiplication skills in late adulthood.

    abstract:BACKGROUND:The role played by cognitive reserve for the maintenance of numeracy skills in late adulthood is still not sufficiently explored. AIMS:This study mainly investigated whether cognitive reserve (i.e., vocabulary) mediates on the relationship between non-verbal reasoning and addition and multiplication skills ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Mulas I,Ruiu M,Fastame MC

    更新日期:2020-06-18 00:00:00

  • Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease.

    abstract:BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Galizia G,Cacciatore F,Testa G,Della-Morte D,Mazzella F,Langellotto A,Raucci C,Gargiulo G,Ferrara N,Rengo F,Abete P

    更新日期:2011-04-01 00:00:00

  • Unmet needs and research challenges for late-life mood disorders.

    abstract::Mood disorders are common and often under-recognised in older people whereby, together with the general ageing of the population, they are becoming a significant and growing public health problem worldwide. However, the need to address the problem of late life mood disorders in a real-world setting is met with a surpr...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Ghio L,Vaggi M,Amore M,Ferrannini L,Natta W

    更新日期:2014-04-01 00:00:00

  • Swallowing dysfunction as risk factor for undernutrition in older people admitted to Swedish short-term care: a cross-sectional study.

    abstract:BACKGROUND:Swallowing dysfunction and risk of undernutrition increase the risk of pneumonia, morbidity, and mortality. Short-term care is an unexplored care context, where many older people stay yearly. AIM:This cross-sectional study aimed to describe and analyze the relationship between swallowing dysfunction and ris...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Hägglund P,Fält A,Hägg M,Wester P,Levring Jäghagen E

    更新日期:2019-01-01 00:00:00

  • Physical functioning, health and survival: a ten-year follow-up study.

    abstract:BACKGROUND AND AIMS:Cutbacks in human resources are putting home care personnel under increasing pressure in their work. Home health care personnel need to know how they can prevent undesirable conditions and support older people towards successful aging. The aim of this ten-year follow-up study was to identify factors...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Arve S,Savikko N,Lavonius S,Lehtonen A,Isoaho H

    更新日期:2006-10-01 00:00:00

  • Coordination of trunk and foot acceleration during gait is affected by walking velocity and fall history in elderly adults.

    abstract:BACKGROUND:Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. AIMS:The aim of the current study was to determine the effects of walking at non-preferred speeds on the coordination bet...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Craig JJ,Bruetsch AP,Huisinga JM

    更新日期:2019-07-01 00:00:00

  • Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).

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    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Chen JM,Huang CQ,Ai M,Kuang L

    更新日期:2013-05-01 00:00:00