Abstract:
OBJECTIVE:To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer's disease (AD), respectively. METHODS:We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer's disease, before and after treatment with a topical testosterone gel. Both patients were hypogonadal at baseline. We assessed cerebral glucose metabolism (CGM) via (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET). We investigated whether there are testosterone-susceptible areas within cerebral structures in patients with Alzheimer's disease. RESULTS:Under testosterone replacement therapy, changes in cerebral glucose metabolism were observed in both patients. Improvement in glucose uptake was observed most consistently in the parietal lobe and brainstem; decreased glucose metabolism was observed in the temporal lobe, the limbic system and the insula for these two subjects. DISCUSSION:These case reports demonstrate the potential for PET scanning to detect changes in cerebral glucose metabolism in hypogonadal men with Alzheimer's disease who are treated with testosterone. Further study will be needed to investigate the consistency and significance of these changes in terms of magnitude and brain region, and the correlation with functional changes.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Tan RSdoi
10.1007/s40520-013-0049-2subject
Has Abstractpub_date
2013-06-01 00:00:00pages
343-7issue
3eissn
1594-0667issn
1720-8319journal_volume
25pub_type
杂志文章abstract:BACKGROUND:The research aim was to study the associations of nature diversity with quality of life (QoL) and depressive symptoms among older people, and whether physical activity explains the associations. METHODS:Community-dwelling people aged 75-90 years (n = 848) living in Central Finland were interviewed in their ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0797-5
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Previous research indicates that dance training may improve balance among older adults. AIMS:This study investigated the effects of Thai traditional dance on balance performance among older women. METHODS:Forty-three women aged 60-80 years, with mean scores between 45 and 52 points on the Berg Balance Scal...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-018-1040-8
更新日期:2019-07-01 00:00:00
abstract::The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND AIMS:External hip protectors have been shown to have a good preventive effect against hip fractures in many studies. However, these studies were carried out either entirely or mostly among older persons living in institutions. The aim of this study was to investigate whether health nurses can, after brie...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324530
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324544
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327370
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Gait disorders are common in the elderly populations, and their prevalence increases with age. Abnormal gait has been associated with greater risk for adverse outcomes in older adults, such as immobility and falls, which in turn lead to loss of functional independence and death. AIM:The purpose of this revi...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-015-0420-6
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. AIMS:The aim of the current study was to determine the effects of walking at non-preferred speeds on the coordination bet...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1036-4
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. AIMS:To create a Japanese version of the SARC-F (SARC-F-J), a questionnaire for diabetic patients, and to investigate its reliability and validity. METHODS:This...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0668-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The process applied to identify fall risks in frail elderly persons remains a matter of debate. We intended to develop a fall screening instrument for clinically defined subgroups of long-term care residents, to be administered by nursing staff. METHODS:Fall risk indicators were selected by multipl...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324595
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01420-2
更新日期:2019-11-22 00:00:00
abstract::The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:In spite of a rapidly ageing population, there is a lack of population-based data on mortality among nursing home residents in Southern Europe. AIMS:To assess mortality rates, their determinants, and causes of death in newly admitted nursing home residents in the Veneto region (northeastern Italy). METHODS...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01441-x
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03324513
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/8757
更新日期:2012-12-01 00:00:00
abstract::Anderson-Fabry's disease (AFD) is a rare inborn X-linked sphingolipid storage disorder. Deficient activity of the lysosomal enzyme alpha-galactosidase A (alpha-GAL-A) leads to progressive accumulation of glycosphingolipids within most visceral tissues and body fluids of affected patients, provoking a clinical syndrome...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324669
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Oxidative stress has been considered one of the causes of aging. For this reason, treatments based on antioxidants or those capable of increasing endogenous antioxidant activity have been taken into consideration to delay aging or age-related disease progression. AIM:In this paper, we determine if resveratr...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0366-8
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Muscle weakness and 25-hydroxyvitamin D (25(OH)D) deficiency have been associated with adverse outcomes among older adults. However, little is known about the relationship between clinically relevant muscle weakness and 25(OH)D levels in Ecuador. AIMS:To examine the prevalence of muscle weakness and its ass...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0678-3
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:This pilot study measured the effects of an original low-intensity training program, called "posture-balancing-mobility" (PBM), on muscular function. METHODS:Nine non-disabled, elderly (74.3 +/- 6 years) subjects were trained with the PBM technique for 11 weeks (2 sessions per week). Mean power and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327350
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Advances such as passive monitoring technology (PMT), which provides holistic supervision of chronically ill and elderly patients, enable and support improved monitoring and observation, thus empowering the growing population of older adults to live more independently while lowering health care expenses. AI...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01323-2
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring f...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0377-5
更新日期:2016-10-01 00:00:00
abstract::In the elderly assessment of renal function by glomerular filtration rate estimation is crucial for diagnostic, therapeutic and prognostic purposes. Our aim is to illustrate the different formulas available and their respective advantages and disadvantages. ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-014-0311-2
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX®) as well as whet...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0634-2
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Impairment in visual-spatial attention can cause difficulties in planning and guiding movements, leading to falls in older adults .The purpose of this study was to investigate the relationship between visual-spatial attention during movement and the risk of falling in older adults. METHODS:Thirty-s...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03325266
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. METHODS:We studied AF patients ≥ 45 years in Sweden 1998-2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Regis...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01449-3
更新日期:2020-11-01 00:00:00
abstract::Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324906
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age. METHODS:Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (avera...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-016-0531-8
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and significance of the clinical application of ultrasound score in assessing the clinical severity of acute cholecystitis in the elderly. METHODS:Pre-surgery ultrasonography was performed on 72 elderly patients with acute cholecystitis who were scheduled for cholecystectomy to...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0236-9
更新日期:2015-02-01 00:00:00
abstract::Milk is a major source of high bioavailable calcium in most developed countries with an average calcium content of 1150 mg/L, providing a ready means of meeting the daily requirements. Its content in other minerals, phosphorus, vitamins, iodine, proteins, potassium and various nutrients is supposed to be beneficial fo...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-019-01192-9
更新日期:2019-06-01 00:00:00
abstract:BACKGROUNDS:Different and new approaches have been proposed to prevent the risk of falling of elderly people, particularly women. AIMS:This study investigates the possibility that a new protocol based on the focal mechanical muscle vibration may reduce the risk of falling of elderly women. METHODS:A pragmatic randomi...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-015-0356-x
更新日期:2015-12-01 00:00:00