Abstract：
BACKGROUND AND AIMS:To assess the incidence and prognostic value of hypoglycemia in hospitalized non-diabetic elderly patients. METHODS:An observational retrospective study, with a 3-year follow-up, was performed in a series of 678 patients aged over 65 years, admitted between January 1 2001 and December 31 2001 to the Units of Gerontology and Geriatrics of the Careggi University Hospital, Florence, Italy. Patients with diabetes mellitus were excluded. To determine the cumulative incidence of hypoglycemia, all measurements of venous or capillary blood glucose during hospital stay were taken into account. In-hospital mortality was determined from hospital discharge records. Information on all-cause, three-year mortality after hospital admission was obtained from the City of Florence Registry Office. RESULTS:Hypoglycemia was observed in 8.6% of patients, and was asymptomatic in about 25% of cases. In-hospital mortality was significantly higher in patients with hypoglycemia (41.4% vs 14.3%; p<0.001), even after adjustment for potential confounders, including comorbidity, indices of malnutrition, and pharmacological treatment (adjusted OR 2.17[1.25;3.85]). 3-year mortality was significantly higher in patients with hypoglycemia during hospital stay, but the difference was not significant after adjustment for confounders. CONCLUSIONS:Hypoglycemia is a prognostic marker of in-hospital mortality in non-diabetic hospitalized patients, even after adjustment for comorbidity and indices of malnutrition. Instead, it does not seem to have any relevant independent prognostic value in the longer term.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Mannucci E,Monami M,Mannucci M,Chiasserini V,Nicoletti P,Gabbani L,Giglioli L,Masotti G,Marchionni Ndoi
10.1007/BF03324842subject
Has Abstractpub_date
2006-10-01 00:00:00pages
446-51issue
5eissn
1594-0667issn
1720-8319pii
3206journal_volume
18pub_type
杂志文章abstract：BACKGROUND AND AIMS:The effect of heavy work-related physical loads (WRPL) on low back pain (LBP) and impaired physical function has been studied extensively in active workers but not in pensioners. METHODS:We compared LBP and physical function in post-menopausal pensioners, divided according to their life-long WRPL i...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324899
更新日期：2009-02-01 00:00:00
abstract：:Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0343-2
更新日期：2015-12-01 00:00:00
abstract：:Age-related macular disease (AMD) is the leading cause of legal blindness among the elderly in Western nations. The magnitude of the problem will undoubtedly grow, as age is a significant risk factor and the number of people aged 65 and over is projected to increase. The most frequent cause of severe visual loss assoc...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/BF03327409
更新日期：2005-12-01 00:00:00
abstract：:We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-015-0383-7
更新日期：2016-10-01 00:00:00
abstract：:Risk for or established malnutrition is frequent in older adults, accompanied by functional limitations, increased morbidity and mortality. Protein-energy malnutrition is often observed and leads besides other predisposing factors to sarcopenia, the increased loss of muscle mass with aging. Sarcopenia is an integral c...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01170-1
更新日期：2019-06-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for thi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-020-01515-1
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Atrial fibrillation (AF) is the most frequent arrhythmia in elderly patients. Aims of this study were to evaluate the predictors of arterial stiffness after external cardioversion (ECV) of AF and to establish whether a link exists between vascular properties and left atrial diameter (LAD). METHODS:...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0173-z
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Multimorbidity in older adults needs to be assessed as it is a risk factor for disability, cognitive decline, and mortality. AIMS:A community-based longitudinal study was performed to determine the incidence and to identify possible predictors of multimorbidity among multiethnic older adults population in M...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1007-9
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01555-7
更新日期：2020-04-16 00:00:00
abstract：:Excess of bone remodeling is still the major pathogenic factor in involutional osteoporosis. This phenomenon is linked to an imbalance between neoformation (by osteoblasts) and resorption (by osteoclasts). Recently, research in drug development is focused on new and more "physiological" approach to balance bone remode...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0086-x
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Slow walking speed as one indicator of physical frailty has been found to be associated with deterioration of the health status. Although many reports have shown that exercise training improves motor function, it is unclear whether a group-based and short-term health promotion intervention will improve motor...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0994-x
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregu...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/6810
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Physical exercise and nutrition seem to have a key role in the management of hip fracture patients. AIM:To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients. METHODS:In th...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-018-1090-y
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324415
更新日期：2002-02-01 00:00:00
abstract：:The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid prof...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-014-0218-y
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emerge...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01735-5
更新日期：2020-11-18 00:00:00
abstract：:Mood disorders are common and often under-recognised in older people whereby, together with the general ageing of the population, they are becoming a significant and growing public health problem worldwide. However, the need to address the problem of late life mood disorders in a real-world setting is met with a surpr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-013-0149-z
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. AIMS:The aim of the current study was to determine the effects of walking at non-preferred speeds on the coordination bet...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-1036-4
更新日期：2019-07-01 00:00:00
abstract：:Despite strong evidence for the efficacy of integrated systems, securing the participation of health professionals, particularly primary care physicians (PCPs), has proven difficult. Novel approaches are needed to resolve these problems. We developed a model - COPA - that is based on scientific evidence and an origina...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327446
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Since oral organs function in the first stage of the swallowing process, it is possible that decline in swallowing function can be partly related to oral frailty. AIMS:The purpose of this study was to investigate the association between swallowing function and oral function among community-dwelling elderly ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01547-7
更新日期：2020-04-18 00:00:00
abstract：:Milk is a major source of high bioavailable calcium in most developed countries with an average calcium content of 1150 mg/L, providing a ready means of meeting the daily requirements. Its content in other minerals, phosphorus, vitamins, iodine, proteins, potassium and various nutrients is supposed to be beneficial fo...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：10.1007/s40520-019-01192-9
更新日期：2019-06-01 00:00:00
abstract：:Osseointegration is a term that refers to the formation of a direct interface between an implant and bone without intervening soft tissue. Cementless femoral fixation in total hip arthroplasty is dependent on mechanical and biological factors that affect implant stability and long-term outcome. Osteoporosis leads to m...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-013-0103-0
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Given the progressive demographic ageing of the population and the National Health System reforms affecting care at the bedside, a periodic re-evaluation of in-hospital mortality rates and associated factors is recommended. AIMS:To describe the occurrence of in-hospital mortality among patients admitted to ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
doi：10.1007/s40520-016-0576-8
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral bl...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327392
更新日期：2004-06-01 00:00:00
abstract：:Celiac disease is a genetic disorder, presenting with malabsorption-related problems because of mucosal damage after ingestion of gluten. The only known effective treatment is a gluten-free diet. Early diagnosis and treatment are essential in preventing complications due to malabsorption. Here we report the case of an...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324644
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people's goal-directed actions. We examined the cross-section...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-017-0762-3
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND AND AIMS:With an increasing population aged 85 years and over, the aim of this study was to describe health status and living conditions in the oldest old and to estimate age and sex differences in a Northern European population. METHODS:A population-based cross-sectional study, The Umeå 85+ Study, was carr...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327426
更新日期：2006-04-01 00:00:00
abstract：AIM:We report 3 cases of spontaneous insufficiency fracture of long bones, to promote awareness of this phenomenon to medical personnel dealing with long-term bedridden patients. METHODS:Cases were analyzed in the light of a literature review. RESULTS:Our patients were all women, who were severely debilitated and had...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324821
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Glycemic control in geriatric patients with type 2 diabetes (T2DM) remains clinically challenging. The objective of this study was to compare the safety and efficacy of insulin lispro in patients C65 years (geriatric) to those\65 years (non-geriatric), using a metaanalysis of randomized controlled c...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,meta分析
doi：10.1007/s40520-013-0125-7
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:Despite the use of the new generation P2Y12 inhibitors (Ticagrelor and Prasugrel) with aspirin is the recommended therapy in acute NSTE-ACS patients, their current use in clinical practice remains quite low and might be related, among several variables, with increased comorbidity burden. We aimed to assess...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
doi：10.1007/s40520-019-01348-7
更新日期：2020-08-01 00:00:00
