Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.


BACKGROUND:Physical exercise and nutrition seem to have a key role in the management of hip fracture patients. AIM:To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients. METHODS:In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. We randomly assigned the participants into two groups (A and B). Both groups performed a physical exercise rehabilitative programme (five sessions of 40 min/week for 2 weeks, followed by a home-based exercise protocol) and received a dietetic counseling; only group A was supplemented with two sachets of 4 g/day of essential amino acids (Aminotrofic®). We evaluated at baseline and after 2 months of intervention (T1): hand grip strength, Timed Up and Go, and Iowa Level of Assistance scale (ILOA). RESULTS:The 32 hip fracture patients (mean aged 79.03 ± 7.80 years) were allocated into two groups: group A (n = 16) and group B (n = 16). All the participants showed significant differences in all outcomes at T1 (p < 0.017). Sarcopenic patients in group A (n = 10) showed statistically significant differences in all the primary outcomes at T1 (p < 0.017), whereas sarcopenic patients in group B (n = 13) showed a significant reduction of ILOA only. In non-sarcopenic patients, we found no differences at T1 in all outcome measures. DISCUSSION:Hip fractures are a complex multifactorial condition of the elderly that determines devastating effects on functioning and independence. CONCLUSION:A multidisciplinary rehabilitative and nutritional intervention seems to be effective on functioning in hip fracture patients, in particular sarcopenic ones.


Aging Clin Exp Res


Invernizzi M,de Sire A,D'Andrea F,Carrera D,Renò F,Migliaccio S,Iolascon G,Cisari C




Has Abstract


2019-10-01 00:00:00














  • Age-associated changes in hand grip and quadriceps muscle strength ratios in healthy adults.

    abstract:BACKGROUND AND AIMS:Muscle strength may decline with age differentially in the upper and lower limbs. This information is difficult to capture through a single measure. The present study therefore aimed to characterize the relative changes in handgrip and lower limb muscle strength with aging by expressing them as a ra...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Samuel D,Wilson K,Martin HJ,Allen R,Sayer AA,Stokes M

    更新日期:2012-06-01 00:00:00

  • Health status in the oldest old. Age and sex differences in the Umeå 85+ Study.

    abstract:BACKGROUND AND AIMS:With an increasing population aged 85 years and over, the aim of this study was to describe health status and living conditions in the oldest old and to estimate age and sex differences in a Northern European population. METHODS:A population-based cross-sectional study, The Umeå 85+ Study, was carr...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: von Heideken Wågert P,Gustavsson JM,Lundin-Olsson L,Kallin K,Nygren B,Lundman B,Norberg A,Gustafson Y

    更新日期:2006-04-01 00:00:00

  • Prevention of falls and role of calcium and vitamin D.

    abstract::Falls in the elderly are very common and represent a serious cause of morbidity, severe disability and death. Impairments of the mechanisms of postural stability with age and the presence of acute and chronic diseases may favour the occurrence of falls in the elderly. Together with the adoption of non-pharmacological ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Gatto S,Gimigliano F,Gimigliano R,Iolascon G

    更新日期:2011-04-01 00:00:00

  • Platelet-to-lymphocyte ratio relates to poor prognosis in elderly patients with acute myocardial infarction.

    abstract:BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Li L,Ma Y,Geng XB,Tan Z,Wang JH,Cui C,Wang HL,Shang XM

    更新日期:2020-04-16 00:00:00

  • Effect of a mixed-exercise program on physical capacity and sedentary behavior in older adults during cancer treatments.

    abstract:BACKGROUND:Aging, cancer and its treatment all contribute to increase the risk of deconditioning and sedentary behaviors. Mixed exercise is recognized to counteract the effects of aging and deconditioning as well as improving physical capacity during cancer treatment in adults. AIMS:To determine the impact of a mixed ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Maréchal R,Fontvieille A,Parent-Roberge H,Fülöp T,Riesco E,Pavic M,Dionne IJ

    更新日期:2019-11-01 00:00:00

  • Relationship between whole body oxygen consumption and skeletal muscle glucose metabolism during walking in older adults: FDG PET study.

    abstract:BACKGROUND AND AIMS:The purpose of this study was to determine the relationship between whole body energy metabolism measured as oxygen consumption (VO2) and local muscle activity measured by positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). METHODS:Ten community- dwelling older women (73-83 yrs) h...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Shimada H,Sturnieks D,Endo Y,Kimura Y,Suzuki T,Oda K,Ishii K,Ishiwata K

    更新日期:2011-06-01 00:00:00

  • Cognitive performance in community-dwelling older adults with stroke and the contribution of age and diffuse subcortical damage: a population-based study in rural Ecuador (The Atahualpa Project).

    abstract:BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Del Brutto OH,Mera RM,Zambrano M,Lama J

    更新日期:2015-10-01 00:00:00

  • Femoral cortical index: an indicator of poor bone quality in patient with hip fracture.

    abstract:BACKGROUND:Osteoporosis is a common disease in elderly, characterized by poor bone quality as a result of alterations affecting trabecular bone. However, recent studies have described also an important role of alterations of cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Feola M,Rao C,Tempesta V,Gasbarra E,Tarantino U

    更新日期:2015-10-01 00:00:00

  • The effect of strength training on control of force in older men and women.

    abstract:BACKGROUND AND AIMS:Age-related structural alterations in motor units and consequential functional manifestations are asserted to underlie the decline in the ability to finely grade, or control, muscular force in upper extremity musculature of older adults. Functional activities requiring appropriately graded muscular ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bellew JW

    更新日期:2002-02-01 00:00:00

  • Effects of a physical activity program on postural stability in older people.

    abstract:BACKGROUND AND AIMS:The objective of this non-randomized study was to determine the influence of a specific physical activity program on the postural stability of older people. METHODS:Seventy-four subjects (72.4 +/- 0.7 yrs) participated in an individualized three-month physical activity program designed to improve p...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Hue OA,Seynnes O,Ledrole D,Colson SS,Bernard PL

    更新日期:2004-10-01 00:00:00

  • Mild polypharmacy and MCI progression in older adults: the mediation effect of drug-drug interactions.

    abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Trevisan C,Limongi F,Siviero P,Noale M,Cignarella A,Manzato E,Sergi G,Maggi S

    更新日期:2019-11-22 00:00:00

  • Income differentials in functional disability in old age: relative risks of onset, recovery, decline, attrition and mortality.

    abstract:BACKGROUND AND AIMS:Socioeconomic status (SES) differences in health decline in late life may be underestimated, because the relatively higher risks of attrition of lower-SES persons are seldom taken into account. This longitudinal study aimed at comparing income differences in the course of disability, non-mortality a...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Broese van Groenou MI,Deeg DJ,Penninx BW

    更新日期:2003-04-01 00:00:00

  • The effect of different test protocols and walking distances on gait speed in older persons.

    abstract:BACKGROUND AND AIMS:Walking is the core physical activity of older persons. The assessment of walking capacity is increasingly important for clinical purposes and clinical research. Differences between assessment tools and protocols for short walks to obtain gait characteristics can be responsible for changes, e.g., in...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Krumpoch S,Lindemann U,Rappl A,Becker C,Sieber CC,Freiberger E

    更新日期:2020-09-15 00:00:00

  • The Charlson Comorbidity and Barthel Index predict length of hospital stay, mortality, cardiovascular mortality and rehospitalization in unselected older patients admitted to the emergency department.

    abstract:BACKGROUND AND AIMS:The Charlson Comorbidity Index (CCI) is the most widely used assessment tool to report the presence of comorbid conditions. The Barthel index (BI) is used to measure performance in activities of daily living. We prospectively investigated the performance of CCI or BI to predict length of hospital st...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bahrmann A,Benner L,Christ M,Bertsch T,Sieber CC,Katus H,Bahrmann P

    更新日期:2019-09-01 00:00:00

  • An algorithm to screen long-term care residents at risk for accidental falls.

    abstract:BACKGROUND AND AIMS:The process applied to identify fall risks in frail elderly persons remains a matter of debate. We intended to develop a fall screening instrument for clinically defined subgroups of long-term care residents, to be administered by nursing staff. METHODS:Fall risk indicators were selected by multipl...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Becker C,Loy S,Sander S,Nikolaus T,Rissmann U,Kron M

    更新日期:2005-06-01 00:00:00

  • Reliability and validity of the Turkish version of the Nottingham Extended Activities of Daily Living Scale.

    abstract:BACKGROUND AND AIMS:The aim of this study was to develop a Turkish version of the Nottingham Extended Activities of Daily Living Scale (NEADLS) and to assess its reliability and validity. METHODS:Sixty healthy volunteers over 67 years old were included in the study. After translation, the Turkish version of the scale ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Sahin F,Yilmaz F,Ozmaden A,Kotevoglu N,Sahin T,Kuran B

    更新日期:2008-10-01 00:00:00

  • Clinically silent idiopathic Parkinson's disease unmasked by valproate use: a brief report.

    abstract::Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Athauda D,Batley R,Ellis C

    更新日期:2015-06-01 00:00:00

  • Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study.

    abstract::The purpose of this study was to evaluate the relationship between 3 eNOS gene polymorphisms and training status (TS) in affecting plasma nitrite concentration (NO2) in normotensive adults over 50 years old. Resting blood pressure (BP) was measured in all participants (n = 101). Plasma was taken to analyze: lipid prof...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: da Silva RF,Sertório JT,Lacchini R,Trapé AA,Tanus-Santos JE,Rush JW,Amaral SL,Zago AS

    更新日期:2014-12-01 00:00:00

  • Familial late-onset Alzheimer's disease: description of an Italian family with four affected siblings and one case of early-onset dementia in the preceding generation.

    abstract::We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Abbate C,Arosio B,Cantatore A,Viti N,Giunco F,Bagarolo R,Nicolini P,Gussago C,Ferri E,Casati M,Rossi PD,Casè A,Bergamaschini L,Vergani C,Mari D

    更新日期:2016-10-01 00:00:00

  • Predictors of institutionalization among home-dwelling older Finnish people: a 22-year follow-up study.

    abstract:BACKGROUND:Identification of predictive factors on institutionalization provides the basis for the development and application of preadmission assessment. There is a lack of evidence for predictors of institutionalization for older people. AIMS:To examine the effect of predictive factors on institutionalization in hom...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,收录出版


    authors: Salminen M,Vire J,Viikari L,Vahlberg T,Isoaho H,Lehtonen A,Viitanen M,Arve S,Eloranta S

    更新日期:2017-06-01 00:00:00

  • Calcium channel blockers and stroke.

    abstract::The most frequent indication for Calcium Channel Blockers (CCBs) is their use as antihypertensive agents for primary or secondary stroke prevention. Hypertension contributes to virtually all mechanisms of stroke, of atherothrombotic, lacunar, cardioembolic and intraparenchymal hemorrhage types. In comparison with the ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Inzitari D,Poggesi A

    更新日期:2005-08-01 00:00:00

  • Physical frailty in older people with severe aortic stenosis.

    abstract:BACKGROUND:Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. AIMS:We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. METHODS:A total of 125 consecutive ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Fukui S,Kawakami M,Otaka Y,Ishikawa A,Mizuno K,Tsuji T,Hayashida K,Inohara T,Yashima F,Liu M

    更新日期:2016-12-01 00:00:00

  • Focal muscle vibration as a possible intervention to prevent falls in elderly women: a pragmatic randomized controlled trial.

    abstract:BACKGROUNDS:Different and new approaches have been proposed to prevent the risk of falling of elderly people, particularly women. AIMS:This study investigates the possibility that a new protocol based on the focal mechanical muscle vibration may reduce the risk of falling of elderly women. METHODS:A pragmatic randomi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Celletti C,Fattorini L,Camerota F,Ricciardi D,La Torre G,Landi F,Filippi GM

    更新日期:2015-12-01 00:00:00

  • Malnutrition and sarcopenia.

    abstract::Risk for or established malnutrition is frequent in older adults, accompanied by functional limitations, increased morbidity and mortality. Protein-energy malnutrition is often observed and leads besides other predisposing factors to sarcopenia, the increased loss of muscle mass with aging. Sarcopenia is an integral c...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Sieber CC

    更新日期:2019-06-01 00:00:00

  • Nature diversity and well-being in old age.

    abstract:BACKGROUND:The research aim was to study the associations of nature diversity with quality of life (QoL) and depressive symptoms among older people, and whether physical activity explains the associations. METHODS:Community-dwelling people aged 75-90 years (n = 848) living in Central Finland were interviewed in their ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Rantakokko M,Keskinen KE,Kokko K,Portegijs E

    更新日期:2018-05-01 00:00:00

  • Lokomat training in vascular dementia: motor improvement and beyond!

    abstract::Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Calabrò RS,De Luca R,Leo A,Balletta T,Marra A,Bramanti P

    更新日期:2015-12-01 00:00:00

  • Quality indicators in acute stroke care: a prospective observational survey in 13 Italian regions.

    abstract:BACKGROUND AND AIMS:Quality monitoring has great relevance in stroke care. The Project "How to guarantee adherence to effective interventions in stroke care" aimed to estimate adherence to acute-phase guidelines in stroke care in Italy. METHODS:A prospective observational study was performed in 27 hospitals of 13 Ital...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Di Carlo A,Accetta G,Bellan M,Terni G,Lamassa M,Facchini R,Biggeri A,Inzitari D,Ferro S,National Stroke Care Group.

    更新日期:2014-06-01 00:00:00

  • An overview of standard statistical methods for assessing exposure-outcome link in survival analysis (Part I): basic concepts.

    abstract::The occurrence of a given disease in a population is measured by prevalence and incidence. Prevalence reflects the burden of a given disease in a specific population and is calculated as point prevalence or period prevalence. Incidence denotes the number of new cases of a given disease which occur in a cohort of indiv...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Tripepi G,Torino C,D'Arrigo G,Bolignano D,Provenzano F,Zoccali C

    更新日期:2012-04-01 00:00:00

  • No modifying effect of nutritional status on statins therapy in relation to all-cause death in older patients with coronary artery disease.

    abstract:BACKGROUND:Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy. AIMS:To investigate whether older patients with CAD w...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Huang BT,Huang FY,Pu XB,Xia TL,Peng Y,Chen F,Yang Y,Liao YB,Chen M

    更新日期:2018-09-01 00:00:00

  • Neutrophil-to-lymphocyte count ratio is associated with perforated appendicitis in elderly patients of emergency department.

    abstract:PURPOSE:The diagnostic value of the neutrophil-to-lymphocyte count ratio (NLR) and the Appendicitis Inflammatory Response (AIR) score for identifying acute appendicitis (AA) perforation in elderly patients in the emergency department (ED) were evaluated. METHODS:A total of 103 patients who were admitted for appendecto...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Jung SK,Rhee DY,Lee WJ,Woo SH,Seol SH,Kim DH,Choi SP

    更新日期:2017-06-01 00:00:00