T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?

abstract：BACKGROUND AND AIMS:External hip protectors have been shown to have a good preventive effect against hip fractures in many studies. However, these studies were carried out either entirely or mostly among older persons living in institutions. The aim of this study was to investigate whether health nurses can, after brie...

journal_title：Aging clinical and experimental research

authors： Heikinheimo R,Jalonen-Männikkö A,Asumaniemi H,Lehtomäki E

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...

journal_title：Aging clinical and experimental research

authors： Aronsson A,Al-Ani NA,Brismar K,Hedström M

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Osteoporosis and fall fractures are increasing problems amongst the elderly. The aim of this study was to explore whether combined population-based and individual interventions directed at risk factors for osteoporosis and falls result in behavioral changes in an elderly population. METHODS:A quasi...

journal_title：Aging clinical and experimental research

authors： Grahn Kronhed AC,Blomberg C,Löfman O,Timpka T,Möller M

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of the present study is to describe the effects of aging on various cognitive domains (global cognitive function, executive function, motor speed) in a population sample of elderly men, and to describe how their age-related changes are influenced by education, depression, or prevalent cerebr...

journal_title：Aging clinical and experimental research

authors： Scuteri A,Palmieri L,Lo Noce C,Giampaoli S

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...

journal_title：Aging clinical and experimental research

authors： Viidik A,Skalicky M

更新日期：2003-12-01 00:00:00

abstract：:In the elderly assessment of renal function by glomerular filtration rate estimation is crucial for diagnostic, therapeutic and prognostic purposes. Our aim is to illustrate the different formulas available and their respective advantages and disadvantages. ...

journal_title：Aging clinical and experimental research

authors： Ungar A,Iacomelli I,Giordano A,Roberts AT,Rafanelli M,Marchionni N

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...

journal_title：Aging clinical and experimental research

authors： Johnen B,Schott N

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. AIMS:We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. METHODS:A total of 125 consecutive ...

journal_title：Aging clinical and experimental research

authors： Fukui S,Kawakami M,Otaka Y,Ishikawa A,Mizuno K,Tsuji T,Hayashida K,Inohara T,Yashima F,Liu M

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Squamous cell carcinoma (SCC) of the oral tongue is one of the most frequent head and neck cancers. The over-70-year age group is the fastest growing segment of the population. Age, however, is not considered a prognostic factor in oral tongue SCC. This study investigated the clinical and histopatho...

journal_title：Aging clinical and experimental research

authors： Soudry E,Preis M,Hod R,Hamzany Y,Hadar T,Bahar G,Sternov Y,Shpitzer T

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Improvements on balance, gait and cognition are some of the benefits of exergames. Few studies have investigated the cognitive effects of exergames in institutionalized older persons. AIMS:To assess the acute effect of a single session of exergames on cognition of institutionalized older persons. METHODS:N...

journal_title：Aging clinical and experimental research

authors： Monteiro-Junior RS,da Silva Figueiredo LF,Maciel-Pinheiro PT,Abud ELR,Braga AEMM,Barca ML,Engedal K,Nascimento OJM,Deslandes AC,Laks J

更新日期：2017-06-01 00:00:00

abstract：:Excess of bone remodeling is still the major pathogenic factor in involutional osteoporosis. This phenomenon is linked to an imbalance between neoformation (by osteoblasts) and resorption (by osteoclasts). Recently, research in drug development is focused on new and more "physiological" approach to balance bone remode...

journal_title：Aging clinical and experimental research

authors： Iolascon G,Resmini G,Tarantino U

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The SarQoL® is a recently developed quality of life questionnaire specific to sarcopenia. AIM:To compare the quality of life (QoL) of subjects identified as sarcopenic with that of non-sarcopenic subjects when using six different operational definitions of sarcopenia. METHODS:Participants of the SarcoPhAge...

journal_title：Aging clinical and experimental research

authors： Beaudart C,Locquet M,Reginster JY,Delandsheere L,Petermans J,Bruyère O

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...

journal_title：Aging clinical and experimental research

authors： Del Brutto OH,Mera RM,Zambrano M,Lama J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some r...

journal_title：Aging clinical and experimental research

authors： Messina OD,Vidal Wilman M,Vidal Neira LF

更新日期：2019-06-01 00:00:00

abstract：:Celiac disease is a genetic disorder, presenting with malabsorption-related problems because of mucosal damage after ingestion of gluten. The only known effective treatment is a gluten-free diet. Early diagnosis and treatment are essential in preventing complications due to malabsorption. Here we report the case of an...

journal_title：Aging clinical and experimental research

authors： Cankurtaran M,Ulger Z,Doğan S,Balam Yavuz B,Halil M,Güllü I,Gedikoğlu G,Anioğul S

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregu...

journal_title：Aging clinical and experimental research

authors： Madden KM,Lockhart C,Khan K

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....

journal_title：Aging clinical and experimental research

authors： Iwasa H,Masui Y,Inagaki H,Yoshida Y,Shimada H,Otsuka R,Kikuchi K,Nonaka K,Yoshida H,Yoshida H,Suzuki T

更新日期：2018-04-01 00:00:00

abstract：:Physical frailty (PF) and sarcopenia are major health issues in geriatric populations, given their high prevalence and association with several adverse outcomes. Nevertheless, the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation. Existing definitional ...

journal_title：Aging clinical and experimental research

authors： Calvani R,Marini F,Cesari M,Tosato M,Picca A,Anker SD,von Haehling S,Miller RR,Bernabei R,Landi F,Marzetti E,SPRINTT Consortium.

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS:The cognitive functions of 98 elderly patients who were scheduled t...

journal_title：Aging clinical and experimental research

authors： Xie H,Huang D,Zhang S,Hu X,Guo J,Wang Z,Zhou G

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Sagittal spinal alignment is an important determinant for proper spinal function. Alterations in spinal alignment may serve as leading factor for diminished body biomechanics. Although increased age is suggested to be associated with changes in lumbosacral alignment, in turn body posture, this is still a cur...

journal_title：Aging clinical and experimental research

authors： Coskun Benlidayi I,Basaran S

更新日期：2015-06-01 00:00:00

abstract：:Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...

journal_title：Aging clinical and experimental research

authors： Veronese N,Reginster JY

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:In addition to the normal process of ageing, frailty, defined as a geriatric syndrome, is becoming more prevalent. Around 10% of people over 65 years and 25-50% of those aged over 85 years are frail. Frail elderly are more vulnerable to external stressors and have an increased risk of adverse health outcomes...

journal_title：Aging clinical and experimental research

authors： Windhaber T,Koula ML,Ntzani E,Velivasi A,Rizos E,Doumas MT,Pappas EE,Onder G,Vetrano DL,Roudriguez Laso A,Roudriguez Manjas L,Illario M,Roller-Wirnsberger RE,ADVANTAGE JA WP8 group.

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Muscle strength may decline with age differentially in the upper and lower limbs. This information is difficult to capture through a single measure. The present study therefore aimed to characterize the relative changes in handgrip and lower limb muscle strength with aging by expressing them as a ra...

journal_title：Aging clinical and experimental research

authors： Samuel D,Wilson K,Martin HJ,Allen R,Sayer AA,Stokes M

更新日期：2012-06-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of 'alternative' therapies. These alternative therapies may have a limited evidence base and, for thi...

journal_title：Aging clinical and experimental research

authors： Fuggle NR,Cooper C,Oreffo ROC,Price AJ,Kaux JF,Maheu E,Cutolo M,Honvo G,Conaghan PG,Berenbaum F,Branco J,Brandi ML,Cortet B,Veronese N,Kurth AA,Matijevic R,Roth R,Pelletier JP,Martel-Pelletier J,Vlaskovska M,Thoma

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Despite evidence of cognitive impairment and difficulties in performing daily activities among elderly people with major depression, studies implementing objective performance-based evaluation of functional deficits in this patient population are scarce. With the aid of a computerized device we exam...

journal_title：Aging clinical and experimental research

authors： Rosenblum S,Werner P,Dekel T,Gurevitz I,Heinik J

更新日期：2010-04-01 00:00:00

abstract：BACKGROUNDS:Different and new approaches have been proposed to prevent the risk of falling of elderly people, particularly women. AIMS:This study investigates the possibility that a new protocol based on the focal mechanical muscle vibration may reduce the risk of falling of elderly women. METHODS:A pragmatic randomi...

journal_title：Aging clinical and experimental research

authors： Celletti C,Fattorini L,Camerota F,Ricciardi D,La Torre G,Landi F,Filippi GM

更新日期：2015-12-01 00:00:00

abstract：:The most frequent indication for Calcium Channel Blockers (CCBs) is their use as antihypertensive agents for primary or secondary stroke prevention. Hypertension contributes to virtually all mechanisms of stroke, of atherothrombotic, lacunar, cardioembolic and intraparenchymal hemorrhage types. In comparison with the ...

journal_title：Aging clinical and experimental research

authors： Inzitari D,Poggesi A

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Influence of cognitive intervention programs on brain activity has not been enough explored. AIMS:The aims of the present study were to clarify changes in brain activity from a cognitive intervention program utilizing the board game "Go" and to examine the relationship between brain activity and the acquisi...

journal_title：Aging clinical and experimental research

authors： Iizuka A,Ishii K,Wagatsuma K,Ishibashi K,Onishi A,Tanaka M,Suzuki H,Awata S,Fujiwara Y

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...

journal_title：Aging clinical and experimental research

authors： Wellens NI,Deschodt M,Boonen S,Flamaing J,Gray L,Moons P,Milisen K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The palliative prognostic index (PPI) is a commonly used tool to predict the life expectancy in palliative care patients. However, there is no universal cutoff, and the accuracy of different cutoffs varies. Therefore, we conducted this meta-analysis to explore the validity and accuracy of different PPI score...

journal_title：Aging clinical and experimental research

authors： Liu Y,Su L,Wang Y,Liu S,Dong B

更新日期：2018-12-01 00:00:00