Medications and fall risk: a case-control study in nursing home residents in Japan.


AIM:Falls are a significant problem for older people, but are few studies of the risk of falling in residents of nursing homes in Japan. We aimed to investigate the risk factors for falls and the association of medication use and falls in nursing home residents in Japan. METHODS:This case-control study reviewed the records of residents of who were ≥ 65 years of age and had fallen in 2012 and an age-, sex-, and facility-matched control group selected from 58 nursing homes in Japan. The odds ratios of potential risk factors and current medications were determined by conditional logistic regression. RESULTS:A total of 1832 residents (916 cases and 916 controls) were included. Falls were significantly associated with an inability to walk without assistance or stand up without assistance, need for toileting assistance, visual impairment, insomnia, and dementia. Current prescription of antithrombotic, nonsteroidal anti-inflammatory, or antiparkinson drugs, muscle relaxants, antiepileptics, antipsychotics, antidepressants, opioids, selective serotonin reuptake inhibitors, and memantine was also associated with increased risk of falling. CONCLUSIONS:Many medications were associated with falls in nursing homes residents in Japan. To prevent these falls, caregivers should provide adequate care, and healthcare professionals should consider switching or dose reduction for these medications.


Aging Clin Exp Res


Park H,Satoh H,Miki A,Maki H,Asai K,Shiraishi A,Urushihara H,Sawada Y




Has Abstract


2020-05-01 00:00:00














  • Association with and predictive capacity of self-perceived risk of falling in recurrent falls in older people: a prospective study.

    abstract:OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Gálvez-Barrón C,Sanguino MJ,Narvaiza L,Cavestany F,Collado I,Macho O,Dapena MD,Rodríguez-Molinero A

    更新日期:2013-10-01 00:00:00

  • Mild polypharmacy and MCI progression in older adults: the mediation effect of drug-drug interactions.

    abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Trevisan C,Limongi F,Siviero P,Noale M,Cignarella A,Manzato E,Sergi G,Maggi S

    更新日期:2019-11-22 00:00:00

  • No modifying effect of nutritional status on statins therapy in relation to all-cause death in older patients with coronary artery disease.

    abstract:BACKGROUND:Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy. AIMS:To investigate whether older patients with CAD w...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Huang BT,Huang FY,Pu XB,Xia TL,Peng Y,Chen F,Yang Y,Liao YB,Chen M

    更新日期:2018-09-01 00:00:00

  • The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health.

    abstract::Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Veronese N,Reginster JY

    更新日期:2019-06-01 00:00:00

  • The effect of aging on gait parameters in able-bodied older subjects: a literature review.

    abstract:BACKGROUND:Gait disorders are common in the elderly populations, and their prevalence increases with age. Abnormal gait has been associated with greater risk for adverse outcomes in older adults, such as immobility and falls, which in turn lead to loss of functional independence and death. AIM:The purpose of this revi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Aboutorabi A,Arazpour M,Bahramizadeh M,Hutchins SW,Fadayevatan R

    更新日期:2016-06-01 00:00:00

  • Pattern of use and presenting complaints of older patients visiting an Emergency Department in Italy.

    abstract:BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Salvi F,Mattioli A,Giannini E,Vita D,Morichi V,Fallani M,Dessì-Fulgheri P,Cherubini A

    更新日期:2013-10-01 00:00:00

  • A carbohydrate-rich drink shortly before surgery affected IGF-I bioavailability after a total hip replacement. A double-blind placebo controlled study on 29 patients.

    abstract:BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Aronsson A,Al-Ani NA,Brismar K,Hedström M

    更新日期:2009-04-01 00:00:00

  • Physical performance among patients aged 70 + in acute care: a preliminar comparison between the Short Physical Performance Battery and the De Morton Mobility Index with regard to sensitivity to change and prediction of discharge destination.

    abstract:BACKGROUND:The Short Physical Performance Battery (SPPB) and the De Morton Mobility Index (DEMMI) are two commonly used instruments to assess mobility in older patients. AIMS:To compare the two assessments in acute senior trauma patients with regard to sensitivity to change during an acute care, and prediction of disc...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Gazzotti A,Meyer U,Freystaetter G,Palzer M,Theiler R,Abderhalden L,Bischoff-Ferrari HA

    更新日期:2020-04-01 00:00:00

  • The nutritional risk and short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation.

    abstract:OBJECTIVE:To determine the association between the level of nutritional risk and the mortality of hospitalized patients with atrial fibrillation. METHODS:In a prospective cohort study, we included patients hospitalized with atrial fibrillation in an internal medicine department in 2007. We calculated the nutritional r...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Díez-Manglano J,Clemente-Sarasa C

    更新日期:2019-12-01 00:00:00

  • Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project.

    abstract::MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Cruz-Jentoft AJ,Daragjati J,Fratiglioni L,Maggi S,Mangoni AA,Mattace-Raso F,Paccalin M,Polidori MC,Topinkova E,Ferrucci L,Pilotto A,MPI_AGE Investigators.

    更新日期:2020-05-01 00:00:00

  • Working late: the impact of work after 70 on longevity, health and function.

    abstract:BACKGROUND AND AIMS:Although many older persons choose to postpone retirement, the health consequences of this decision are still debated. This study aimed at determining the impact of continued employment on life-style, well-being, health and survival in a cohort of community-dwelling 70-year-olds. METHODS:A longitud...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Hammerman-Rozenberg R,Maaravi Y,Cohen A,Stessman J

    更新日期:2005-12-01 00:00:00

  • Influence of bone densitometry on the anti-osteoporosis treatment after fragility hip fracture.

    abstract:BACKGROUND:Fragility fracture significantly increases risk of future fracture. The fragility fracture cycle should be disrupted. The secondary fracture prevention is important for the patients with fragility hip fracture. The pharmacotherapy for osteoporosis is important for prevention of new fracture. However, many pa...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Wang P,Li Y,Zhuang H,Yu H,Cai S,Xu H,Chen Z,Lin J,Yao X

    更新日期:2019-10-01 00:00:00

  • The contribution of CNVs to the most common aging-related neurodegenerative diseases.

    abstract::Alzheimer and Parkinson's diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address these complex multifactorial traits, a systems biolog...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Gentile G,La Cognata V,Cavallaro S

    更新日期:2020-02-06 00:00:00

  • Suicide and euthanasia in late life.

    abstract::Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, persona...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: De Leo D,Spathonis K

    更新日期:2003-04-01 00:00:00

  • Second-order visual sensitivity in the aging population.

    abstract::Most visual and cognitive functions are affected by aging over the lifespan. In this study, our aim was to investigate the loss in sensitivity to different classes of second-order stimuli-a class of stimuli supposed to be mainly processed in extrastriate cortex-in the aging population. These stimuli will then allow on...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Reynaud A,Tang Y,Zhou Y,Hess RF

    更新日期:2019-05-01 00:00:00

  • Acetabular fragility fractures in elderly patients.

    abstract::The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: D'Imporzano M,Liuni FM,Tarantino U

    更新日期:2011-04-01 00:00:00

  • Feasibility of a machine vs free weight strength training program and its effects on physical performance in nursing home residents: a pilot study.

    abstract:BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Johnen B,Schott N

    更新日期:2018-07-01 00:00:00

  • Physical activity among hospitalised older people: insights from upper and lower limb accelerometry.

    abstract:BACKGROUND:Few studies have explored the activity levels of hospitalised older people and the intra-daily activity patterns in this group have not been described. AIMS:To describe the quantity and daily pattern of physical activity among hospitalised older people using two accelerometers: the ankle-worn StepWatch Acti...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Lim SER,Dodds R,Bacon D,Sayer AA,Roberts HC

    更新日期:2018-11-01 00:00:00

  • Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

    abstract:BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

    更新日期:2012-02-01 00:00:00

  • Representativeness of the "Fiesole Misurata" study database for use in pharmaco-epidemiological investigations on adherence to antihypertensive medications.

    abstract:BACKGROUND AND AIMS:Poor adherence to medications is a major health concern especially among older subjects. To plan future studies to improve adherence, an epidemiological study, called "Fiesole Misurata", was conducted. The aim of the present paper was to verify the representativeness of the database in evaluating th...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Lapi F,Lucenteforte E,Moschini M,Bonaiuti R,Di Pirro M,Barchielli A,Benemei S,Belladonna M,Nesti N,Coppini R,Taras M,Vannacci A,Ungar A,Mugelli A

    更新日期:2013-08-01 00:00:00

  • Is it safe and useful, laparoscopic peritoneal lavage in the treatment of acute diverticulitis of octogenarian patients? A multicenter retroprospective observational study.

    abstract:BACKGROUND:Diverticular disease of the colon also affects older people. Generally, older patients with diverticulitis may be regarded as too risky to undergo surgery. This retroprospective multicentric observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage (LPL) in elderly patients...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Boselli C,Gemini A,Cirocchi R,Grassi V,Avenia S,Polistena A,Sanguinetti A,Pironi D,Santoro A,Tabola R,Burattini MF,Avenia N

    更新日期:2017-02-01 00:00:00

  • Step adjustments among young and elderly when walking toward a raised surface.

    abstract:BACKGROUND:Falls among the elderly are often associated with walking on uneven ground. Obstacle negotiation requires both postural reaction strategies and anticipatory strategies which may be impaired with age. Anticipatory strategies are necessary in many daily living situations such as crossing the street and negotia...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Laessoe U,Voigt M

    更新日期:2013-06-01 00:00:00

  • Cognitive performance in community-dwelling older adults with stroke and the contribution of age and diffuse subcortical damage: a population-based study in rural Ecuador (The Atahualpa Project).

    abstract:BACKGROUND:Cognitive impairment is common among stroke survivors. However, there is controversy on the role of the stroke itself or the associated subcortical damage in post-stroke cognitive decline. AIM:To assess the independent contribution and the interaction of age, the stroke itself and diffuse subcortical damage...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Del Brutto OH,Mera RM,Zambrano M,Lama J

    更新日期:2015-10-01 00:00:00

  • Lokomat training in vascular dementia: motor improvement and beyond!

    abstract::Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Calabrò RS,De Luca R,Leo A,Balletta T,Marra A,Bramanti P

    更新日期:2015-12-01 00:00:00

  • Executive function and life-space mobility in old age.

    abstract:BACKGROUND:Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people's goal-directed actions. We examined the cross-section...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Poranen-Clark T,von Bonsdorff MB,Rantakokko M,Portegijs E,Eronen J,Kauppinen M,Eriksson JG,Rantanen T,Viljanen A

    更新日期:2018-02-01 00:00:00

  • Familial late-onset Alzheimer's disease: description of an Italian family with four affected siblings and one case of early-onset dementia in the preceding generation.

    abstract::We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Abbate C,Arosio B,Cantatore A,Viti N,Giunco F,Bagarolo R,Nicolini P,Gussago C,Ferri E,Casati M,Rossi PD,Casè A,Bergamaschini L,Vergani C,Mari D

    更新日期:2016-10-01 00:00:00

  • The Frailty Index in centenarians and their offspring.

    abstract::Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians,...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Arosio B,Ferri E,Casati M,Mari D,Vitale G,Cesari M

    更新日期:2019-11-01 00:00:00

  • Disability trajectories and mortality in older adults with different cognitive and physical profiles.

    abstract:BACKGROUND:Cognitive and physical deficits independently raise the risk for negative events in older adults. Less is known about whether their co-occurrence constitutes a distinct risk profile. This study quantifies the association between cognitive impairment, no dementia (CIND), slow walking speed (WS) and their comb...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Grande G,Vetrano DL,Fratiglioni L,Marseglia A,Vanacore N,Laukka EJ,Welmer AK,Rizzuto D

    更新日期:2020-06-01 00:00:00

  • Total lymphocyte count and in-hospital mortality in older persons with multimorbidity.

    abstract:BACKGROUND AND AIMS:Low total lymphocyte count (TLC) has been found to be a poor prognostic factor in adults affected by heart diseases, malignancy, and renal failure. The aims of this study were to verify if a low TLC was associated with in-hospital mortality in older persons and to evaluate whether this association w...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Marengoni A,Petroboni B,Casella S,Martinelli D,Cossi S

    更新日期:2008-08-01 00:00:00

  • The effects of interdisciplinary outpatient geriatrics on the use, costs and quality of health services in the fee-for-service environment.

    abstract:BACKGROUND AND AIMS:To evaluate the effect of interdisciplinary outpatient geriatrics on the use, cost, and quality of health services in a fee-for-service (FFS) environment of two networks of primary care clinics operated by a not-for-profit provider organization in Dallas County, Texas. METHODS:The Senior Health Net...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Famadas JC,Frick KD,Haydar ZR,Nicewander D,Ballard D,Boult C

    更新日期:2008-12-01 00:00:00