Factors influencing attrition in 35 Alzheimer's Disease Centers across the USA: a longitudinal examination of the National Alzheimer's Coordinating Center's Uniform Data Set.


OBJECTIVE:A lack of understanding of the causes of attrition in longitudinal studies of older adults may lead to higher attrition rates and bias longitudinal study results. In longitudinal epidemiological studies of Alzheimer's disease and related dementias, high rates of attrition may cause a systematic underestimation of dementia prevalence and skew the characterization of the disease. This can compromise the generalizability of the study results and any inferences based on the surviving sample may grossly misrepresent the importance of the risk factors for dementia. The National Institute on Aging outlined a National Strategy for Recruitment and Participation in Alzheimer's Disease Clinical Research to address this problem, providing evidence of the magnitude of this problem. METHOD:To explore predictors of attrition, this study examined the National Alzheimer's Coordinating Center (NACC) Uniform Data Set, a repository of observations of older adults spanning 11 years, using survival analysis. Four samples were examined: the full sample (n = 30,433), the alive subsample excluding those who died (n = 24,231), the MRI sample [participants with complete MRI data (n = 1104)], and the alive MRI subsample [participants with MRI data excluding those who died (n = 947)]. RESULTS:Worsening cognitive impairment, neuropsychiatric symptoms, and difficulty with functional activities predicted attrition, as did lower hippocampal volume in the MRI subsample. Questionable co-participant reliability and an informant other than a spouse also increased risk of attrition. DISCUSSION:Special considerations exist in recruiting and retaining older adults in longitudinal studies, and results of baseline psychological, functional, and cognitive functioning should be used to identify targeted retention strategies.


Aging Clin Exp Res


Burke SL,Hu T,Naseh M,Fava NM,O'Driscoll J,Alvarez D,Cottler LB,Duara R




Has Abstract


2019-09-01 00:00:00














  • 79-year-old post-menopausal woman with humerus fracture during teriparatide treatment.

    abstract::The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Resmini G,Iolascon G

    更新日期:2007-08-01 00:00:00

  • Sarcopenic obesity: research advances in pathogenesis and diagnostic criteria.

    abstract::Sarcopenic obesity (SO) refers to an obesity disease accompanied by low skeletal muscle quality, strength and/or function, which is more common in the elderly and seriously affects their quality of life and can lead to falls, unstable walking, balance disorders and fractures in the elderly. The increase in aging popul...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Xie WQ,Xiao GL,Fan YB,He M,Lv S,Li YS

    更新日期:2019-12-16 00:00:00

  • Platelet-to-lymphocyte ratio relates to poor prognosis in elderly patients with acute myocardial infarction.

    abstract:BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Li L,Ma Y,Geng XB,Tan Z,Wang JH,Cui C,Wang HL,Shang XM

    更新日期:2020-04-16 00:00:00

  • The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health.

    abstract::Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limi...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Veronese N,Reginster JY

    更新日期:2019-06-01 00:00:00

  • Economic evaluation of passive monitoring technology for seniors.

    abstract:BACKGROUND:Advances such as passive monitoring technology (PMT), which provides holistic supervision of chronically ill and elderly patients, enable and support improved monitoring and observation, thus empowering the growing population of older adults to live more independently while lowering health care expenses. AI...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Schneider JE,Cooper J,Scheibling C,Parikh A

    更新日期:2020-07-01 00:00:00

  • Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate the effect of nutrition combined physical exercise interventions on age-related cognitive decline by a systematic review and meta-analysis. METHODS:We searched 9 databases, including PubMed, EMbase, The Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure (CNK...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Liu T,Li N,Hou Z,Liu L,Gao L,Wang L,Tan J

    更新日期:2020-10-14 00:00:00

  • Effects of a physical activity program on postural stability in older people.

    abstract:BACKGROUND AND AIMS:The objective of this non-randomized study was to determine the influence of a specific physical activity program on the postural stability of older people. METHODS:Seventy-four subjects (72.4 +/- 0.7 yrs) participated in an individualized three-month physical activity program designed to improve p...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Hue OA,Seynnes O,Ledrole D,Colson SS,Bernard PL

    更新日期:2004-10-01 00:00:00

  • Comparison of trabecular bone score and hip structural analysis with FRAX® in postmenopausal women with type 2 diabetes mellitus.

    abstract:PURPOSE:To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX®) as well as whet...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bonaccorsi G,Fila E,Messina C,Maietti E,Ulivieri FM,Caudarella R,Greco P,Guglielmi G

    更新日期:2017-10-01 00:00:00

  • Quality of life in sarcopenia measured with the SarQoL®: impact of the use of different diagnosis definitions.

    abstract:BACKGROUND:The SarQoL® is a recently developed quality of life questionnaire specific to sarcopenia. AIM:To compare the quality of life (QoL) of subjects identified as sarcopenic with that of non-sarcopenic subjects when using six different operational definitions of sarcopenia. METHODS:Participants of the SarcoPhAge...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Beaudart C,Locquet M,Reginster JY,Delandsheere L,Petermans J,Bruyère O

    更新日期:2018-04-01 00:00:00

  • Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.

    abstract::Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD). Acetylcholinesterase inhibitors (AChEI), the symptomatic therapy in AD, attenuate and delay the cognitive deficit by enhancing cholinergic synapses...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Benfante R,Di Lascio S,Cardani S,Fornasari D

    更新日期:2019-10-03 00:00:00

  • Working late: the impact of work after 70 on longevity, health and function.

    abstract:BACKGROUND AND AIMS:Although many older persons choose to postpone retirement, the health consequences of this decision are still debated. This study aimed at determining the impact of continued employment on life-style, well-being, health and survival in a cohort of community-dwelling 70-year-olds. METHODS:A longitud...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Hammerman-Rozenberg R,Maaravi Y,Cohen A,Stessman J

    更新日期:2005-12-01 00:00:00

  • Gait reveals bilateral adaptation of motor control in patients with chronic unilateral stroke.

    abstract:BACKGROUND AND AIMS:Functional brain imaging has shown that bilateral brain reorganization may occur after unilateral cerebral damage. The present study searched for evidence of bilateral motor control changes in gait in patients with chronic unilateral stroke. METHODS:Gait variables (temporal and spatial parameters, ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Titianova EB,Peurala SH,Pitkänen K,Tarkka IM

    更新日期:2008-04-01 00:00:00

  • Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

    abstract:BACKGROUND:Physical exercise and nutrition seem to have a key role in the management of hip fracture patients. AIM:To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients. METHODS:In th...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,随机对照试验


    authors: Invernizzi M,de Sire A,D'Andrea F,Carrera D,Renò F,Migliaccio S,Iolascon G,Cisari C

    更新日期:2019-10-01 00:00:00

  • Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).

    abstract:OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Chen JM,Huang CQ,Ai M,Kuang L

    更新日期:2013-05-01 00:00:00

  • Depression in the elderly: new concepts and therapeutic approaches.

    abstract::Depression is one of the leading causes of suffering in the elderly, but it is often under-diagnosed and under-treated, partly due to the false belief that depression is a common aspect of aging. Depression in the elderly is frequently comorbid with medical illnesses, may often be expressed by somatic complaints, and ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Mecocci P,Cherubini A,Mariani E,Ruggiero C,Senin U

    更新日期:2004-06-01 00:00:00

  • T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?

    abstract::Dysfunctional T-cell immunity contributes to susceptibility to infectious disease in the elderly. A characteristic feature of this "immunosenescence" is the predominance of clonal expansions of CD8 cells and decreased diversity of the T-cell antigen receptor repertoire. Lifelong chronic antigenic stress commonly cause...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Pawelec G,Gouttefangeas C

    更新日期:2006-04-01 00:00:00

  • Related factors of cognitive impairment in community-dwelling older adults in Beijing Longitudinal Study of Aging.

    abstract:OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Han R,Tang Z,Ma L

    更新日期:2019-01-01 00:00:00

  • The Italian version of the "frailty index" based on deficits in health: a validation study.

    abstract:BACKGROUND AND AIM:Several measurements were taken for frailty classification in geriatric population. "Frailty index" is based on "deficits in health," but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of "frailty index" for the Italian geriatric community. ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Abete P,Basile C,Bulli G,Curcio F,Liguori I,Della-Morte D,Gargiulo G,Langellotto A,Testa G,Galizia G,Bonaduce D,Cacciatore F

    更新日期:2017-10-01 00:00:00

  • Hydration status of community-dwelling seniors.

    abstract:BACKGROUND AND AIMS:Dehydration is the most common fluid or electrolyte disorder among older persons. This study was designed to examine the hydration status of community-dwelling seniors. METHODS:Blood and urine samples were collected from 67 independently living volunteers (65-93 yrs) who had functional limitations ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,多中心研究


    authors: Morgan AL,Masterson MM,Fahlman MM,Topp RV,Boardley D

    更新日期:2003-08-01 00:00:00

  • Impaired choice stepping in response to a visual-spatial attention demanding task among older adults at high risk of falling: a pilot study.

    abstract:BACKGROUND AND AIMS:Impairment in visual-spatial attention can cause difficulties in planning and guiding movements, leading to falls in older adults .The purpose of this study was to investigate the relationship between visual-spatial attention during movement and the risk of falling in older adults. METHODS:Thirty-s...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Uemura K,Yamada M,Nagai K,Tanaka B,Mori S

    更新日期:2012-08-01 00:00:00

  • Diagnostic and treatment practices of delirium in a general hospital.

    abstract:BACKGROUND:Despite the increase in research on delirium, it remains underdiagnosed and difficult to manage, and the outcome is poor especially in older people. AIMS:To identify the clinically diagnosed rates of delirium, the possible aetiologies, to describe treatment, number and type of psychotropic medication used a...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Rooney S,Qadir M,Adamis D,McCarthy G

    更新日期:2014-12-01 00:00:00

  • Decreased cell proliferation and altered cytokine production in frail older adults.

    abstract:BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral bl...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Leng SX,Yang H,Walston JD

    更新日期:2004-06-01 00:00:00

  • Role of functional performance in diagnosis of dementia in elderly people with low educational level living in Southern Italy.

    abstract:BACKGROUND AND AIMS:Diagnosis of dementia is often difficult in subjects with low educational level. Our aim was to evaluate the role of functional performance and the possibility of preferring scores of activities of daily living (ADL) and instrumental activities of daily living (IADL) in screening elderly people for ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Iavarone A,Milan G,Vargas G,Lamenza F,De Falco C,Gallotta G,Postiglione A

    更新日期:2007-04-01 00:00:00

  • Effectiveness of exercise in the treatment of lumbar spinal stenosis, knee osteoarthritis, and osteoporosis.

    abstract:BACKGROUND AND AIMS:Lumbar spinal stenosis (LSS), osteoarthritis (OA) of the knee, and osteoporosis are major locomotive diseases in the elderly population. The aim of this study was to examine the effectiveness of exercise in these three diseases. METHODS:We reviewed the relevant literature, i.e., systematic reviews ...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Iwamoto J,Sato Y,Takeda T,Matsumoto H

    更新日期:2010-04-01 00:00:00

  • Comorbidities, polypharmacy, functionality and nutritional status in Turkish community-dwelling female elderly.

    abstract:BACKGROUND AND AIMS:Most elderly persons live in developing countries where current geriatric epidemiological data are scarce. We aimed to study major comorbidities, polypharmacy, functional and nutritional status in a Turkish community-dwelling female elderly clinic population. METHODS:Female geriatrics outpatient cl...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Bahat G,Tufan F,Bahat Z,Tufan A,Aydin Y,Akpinar TS,Nadir S,Erten N,Karan MA

    更新日期:2014-06-01 00:00:00

  • Left ventricular hypertrophy and blood pressure as predictors of cognitive decline in old age.

    abstract:BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Kähönen-Väre M,Brunni-Hakala S,Lindroos M,Pitkala K,Strandberg T,Tilvis R

    更新日期:2004-04-01 00:00:00

  • Squamous cell carcinoma of the oral tongue in patients over 75 years old.

    abstract:BACKGROUND AND AIMS:Squamous cell carcinoma (SCC) of the oral tongue is one of the most frequent head and neck cancers. The over-70-year age group is the fastest growing segment of the population. Age, however, is not considered a prognostic factor in oral tongue SCC. This study investigated the clinical and histopatho...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Soudry E,Preis M,Hod R,Hamzany Y,Hadar T,Bahar G,Sternov Y,Shpitzer T

    更新日期:2011-06-01 00:00:00

  • Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.

    abstract:BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

    更新日期:2012-02-01 00:00:00

  • The contribution of CNVs to the most common aging-related neurodegenerative diseases.

    abstract::Alzheimer and Parkinson's diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address these complex multifactorial traits, a systems biolog...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章,评审


    authors: Gentile G,La Cognata V,Cavallaro S

    更新日期:2020-02-06 00:00:00

  • Overall mortality and causes of death in newly admitted nursing home residents.

    abstract:BACKGROUND:In spite of a rapidly ageing population, there is a lack of population-based data on mortality among nursing home residents in Southern Europe. AIMS:To assess mortality rates, their determinants, and causes of death in newly admitted nursing home residents in the Veneto region (northeastern Italy). METHODS...

    journal_title:Aging clinical and experimental research

    pub_type: 杂志文章


    authors: Braggion M,Pellizzari M,Basso C,Girardi P,Zabeo V,Lamattina MR,Corti MC,Fedeli U

    更新日期:2020-02-01 00:00:00