Abstract:
BACKGROUND:Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS:We aimed to explore the relationship between clinical symptoms and physical findings with radiographic diagnoses of tibiofemoral and patellofemoral OA. METHODS:This study was based on 409 individuals from the Hertfordshire Cohort Study, born between 1931 and 1939. Antero-posterior and lateral radiographs were taken of both knees. The presence of tibiofemoral and patellofemoral OA was defined according to the Kellgren and Lawrence score. Clinical symptoms, assessed using WOMAC, and physical findings were ascertained by examination. Relationships were assessed using multilevel univariate logistic regression. RESULTS:In the 775 knees studied, the prevalence of physical findings was crepitus (25%), tibiofemoral tenderness (15%), bony swelling (12%), and pain on flexion (10%). Thirty-one percent (n = 238) knees demonstrated tibiofemoral OA, 28% (n = 220) showed patellofemoral OA, and 16% demonstrated OA in both locations. A global clinical symptom score was associated with increased risk of tibiofemoral OA (OR 12.5, 95% CI 5.4-29.0) and patellofemoral OA (OR 5.1, 95% CI 2.3-13.1). On clinical examination, the presence of crepitus, tibiofemoral tenderness, bony swelling, and pain on flexion was associated with increased risk of tibiofemoral OA; however, only tenderness was found to be associated with patellofemoral OA. CONCLUSION:Global clinical symptom score was associated with radiographic tibiofemoral and patellofemoral OA. However, individual clinical signs were more strongly associated with tibiofemoral than patellofemoral OA.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Parsons C,Fuggle NR,Edwards MH,Goulston L,Litwic AE,Jagannath D,van der Pas S,Cooper C,Dennison EM,EPOSA Research Group.doi
10.1007/s40520-017-0847-zsubject
Has Abstractpub_date
2018-01-01 00:00:00pages
17-25issue
1eissn
1594-0667issn
1720-8319pii
10.1007/s40520-017-0847-zjournal_volume
30pub_type
杂志文章abstract:OBJECTIVES:The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age. METHODS:Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (avera...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-016-0531-8
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties....
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0786-8
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:For people with dementia, moving into a nursing home is usually considered at some point in time. Currently available information on predictors of institutionalization is often based on small sample sizes, not taking competing risks into account, and with inconclusive results for sex. AIMS:We aimed to carry...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0737-4
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emerge...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01735-5
更新日期:2020-11-18 00:00:00
abstract:INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a p...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01353-w
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Hip fractures (HF) are a major issue worldwide. We aimed at evaluating the practices in delivering care to patients with HF among several Italian Orthogeriatric centers. METHODS:The study took place from February 2016 to July 2018. Seven performance indicators (pre-surgical cognitive assessment, surgery per...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01488-1
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer's disease (AD), respectively. METHODS:We describe the clinical and positron emission tomography (PET) findings for two individuals, one with ea...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0049-2
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03325234
更新日期:2011-10-01 00:00:00
abstract::Mood disorders are common and often under-recognised in older people whereby, together with the general ageing of the population, they are becoming a significant and growing public health problem worldwide. However, the need to address the problem of late life mood disorders in a real-world setting is met with a surpr...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-013-0149-z
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. AIMS:In order to assure broader coverage o...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0651-1
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0112-z
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIM:Sarcopenia and sarcopenic obesity (SO) are associated with adverse health outcomes in older people. Data on sarcopenia- and SO-related mortality are insufficient for hospitalized older people. The aim of this study was to evaluate the relationship between sarcopenia, SO and mortality among hospitaliz...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01277-5
更新日期:2019-11-01 00:00:00
abstract::Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0343-2
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The incidence and costs of acute myocardial infarction (AMI) in Europe represent a substantial problem due to population aging. METHODS:Between 2001 and 2005, Italian hospitalization records were examined to evaluate hospital admissions and costs of AMI in adults aged ≥ 45 and in elderly people ≥ 65 or ≥ 75...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03337744
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institu...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-017-0830-8
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Fall-induced deaths of elderly people are a major problem. AIM AND METHODS:Using the Official Cause-of-Death Statistics of Finland, we aimed to determine the current trends in the number and age-adjusted incidence (per 100,000 persons) of fall deaths among older Finns by taking into account 50 years or olde...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0898-9
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Functional brain imaging has shown that bilateral brain reorganization may occur after unilateral cerebral damage. The present study searched for evidence of bilateral motor control changes in gait in patients with chronic unilateral stroke. METHODS:Gait variables (temporal and spatial parameters, ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324759
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327370
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324544
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Although many older persons choose to postpone retirement, the health consequences of this decision are still debated. This study aimed at determining the impact of continued employment on life-style, well-being, health and survival in a cohort of community-dwelling 70-year-olds. METHODS:A longitud...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327419
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01420-2
更新日期:2019-11-22 00:00:00
abstract:BACKGROUND AND AIMS:Declines in hamstrings and quadriceps maximal and rapid strength are commonly reported as a consequence of aging; however, few studies have investigated the influence of age on maximal and rapid hamstrings to quadriceps (H/Q) strength ratios. This study aimed to examine the effects of age on leg ext...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0734-7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Art-based activities like painting workshops demonstrated health benefits in older individuals living in home care facilities. Few studies examined the effects of painting workshops in geriatric inpatients. AIM:The study aims to examine whether the participation in painting workshops performed in patients a...
journal_title:Aging clinical and experimental research
pub_type: 临床试验,杂志文章
doi:10.1007/s40520-020-01675-0
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregu...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/6810
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND AIMS:In order to investigate the relation between personal functional capacity and the physical housing environment during the aging process, the aim of this study was to give a long-term description of person-environmental fit (P-E fit) problems in terms of housing accessibility and ADL dependence among...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03325154
更新日期:2008-10-01 00:00:00
abstract::The most frequent indication for Calcium Channel Blockers (CCBs) is their use as antihypertensive agents for primary or secondary stroke prevention. Hypertension contributes to virtually all mechanisms of stroke, of atherothrombotic, lacunar, cardioembolic and intraparenchymal hemorrhage types. In comparison with the ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Poor adherence to medications is a major health concern especially among older subjects. To plan future studies to improve adherence, an epidemiological study, called "Fiesole Misurata", was conducted. The aim of the present paper was to verify the representativeness of the database in evaluating th...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0060-7
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0746-3
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is highly prevalent and increasing in geriatric population. Depression and sleep disorders occur at a higher rate in patients with diabetes compared with controls. AIM:The purpose of this study was to demonstrate whether diabetic complications influence the sleep quality and depressio...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0293-0
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Multimorbidity in older adults needs to be assessed as it is a risk factor for disability, cognitive decline, and mortality. AIMS:A community-based longitudinal study was performed to determine the incidence and to identify possible predictors of multimorbidity among multiethnic older adults population in M...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1007-9
更新日期:2019-02-01 00:00:00