Abstract：
INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a pilot study to investigate the role of exercise intensity on BDNF levels in people with PD. METHODS:Participants of early- to mid-stage disease were recruited from a single PD service in north-east England, UK into two separate studies of exercise in PD, one involving moderate-intensity continuous training (MICT) and one involving high-intensity interval training (HIIT), both had control groups. In both the interventions, participants exercise three times per week for 12 weeks. Blood samples were taken for BDNF analysis at the start and end of the first session and the start and end of the final session, with corresponding samples taken in controls. RESULTS:Data were available for 27 participants (13 intervention, 14 control) in the MICT intervention and 17 (9 intervention, 8 control) in the HIIT intervention. BDNF level did not rise significantly from the start to end of individual sessions. Across the 12 week period, they rose significantly in the HIIT intervention group, but not in controls or the MICT intervention group. CONCLUSIONS:High-intensity interval training appears to have a greater impact on BDNF than MICT. Future work should directly compare exercise modalities and investigate the impact of BDNF levels on disease progression and quality of life.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
O'Callaghan A,Harvey M,Houghton D,Gray WK,Weston KL,Oates LL,Romano B,Walker RWdoi
10.1007/s40520-019-01353-wsubject
Has Abstractpub_date
2020-09-01 00:00:00pages
1731-1738issue
9eissn
1594-0667issn
1720-8319pii
10.1007/s40520-019-01353-wjournal_volume
32pub_type
杂志文章abstract：BACKGROUND:Improvements on balance, gait and cognition are some of the benefits of exergames. Few studies have investigated the cognitive effects of exergames in institutionalized older persons. AIMS:To assess the acute effect of a single session of exergames on cognition of institutionalized older persons. METHODS:N...
journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,meta分析,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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更新日期：2011-04-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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更新日期：2013-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
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更新日期：2014-02-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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