Abstract：
BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--lifelong physical exercise increases the mean life span but not the maximum life span, while food restriction increases both life spans. We studied male Sprague-Dawley rats in order to further analyze these beneficial effects. METHODS:We compared voluntary running in wheels (RW) with food restriction to pair weight with RW (PW), and mild forced running in treadmill (TM)--all animals housed individually. Control groups were sedentary ad libitum-fed animals housed individually (S1) and four to a cage (S4). The collagen biomarker of aging was calculated as a composite parameter from thermal stability data for 5 (baseline), 15, 19 and 23 months of age. RESULTS:In RW and PW, the increase in the composite parameter was retarded to the same extent. The retardation in TM was less efficient. S4 had the highest value for the composite parameter, together with the highest body weight and fat content. In groupwise comparisons, the composite parameter tended to predict survival in the groups up to the age of 23 months. CONCLUSIONS:Voluntary running in wheels is more beneficial than mild-forced exercise on the treadmill. The composite parameter is a useful indicator of different interventions on aging rats.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Viidik A,Skalicky Mdoi
10.1007/BF03327370subject
Has Abstractpub_date
2003-12-01 00:00:00pages
475-81issue
6eissn
1594-0667issn
1720-8319journal_volume
15pub_type
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324608
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03324530
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03337747
更新日期：2011-06-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2020-06-18 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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更新日期：2009-04-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND AND AIMS:Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a wi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
