当前位置： SCI文献检索 > AGING CLINICAL AND EXPERIMENTAL RESEARCH期刊下所有文献 > Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging.

Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging.

Abstract：

BACKGROUND AND AIMS:Obesity and lack of physical exercise characterize increasing numbers of people in Western societies, resulting in increasing morbidity and mortality. Regular physical exercise, on the other hand, has been shown to be beneficial. Beneficial effects have also been shown in laboratory rodent studies--lifelong physical exercise increases the mean life span but not the maximum life span, while food restriction increases both life spans. We studied male Sprague-Dawley rats in order to further analyze these beneficial effects. METHODS:We compared voluntary running in wheels (RW) with food restriction to pair weight with RW (PW), and mild forced running in treadmill (TM)--all animals housed individually. Control groups were sedentary ad libitum-fed animals housed individually (S1) and four to a cage (S4). The collagen biomarker of aging was calculated as a composite parameter from thermal stability data for 5 (baseline), 15, 19 and 23 months of age. RESULTS:In RW and PW, the increase in the composite parameter was retarded to the same extent. The retardation in TM was less efficient. S4 had the highest value for the composite parameter, together with the highest body weight and fat content. In groupwise comparisons, the composite parameter tended to predict survival in the groups up to the age of 23 months. CONCLUSIONS:Voluntary running in wheels is more beneficial than mild-forced exercise on the treadmill. The composite parameter is a useful indicator of different interventions on aging rats.

journal_name

Aging Clin Exp Res

journal_title

Aging clinical and experimental research

authors

Viidik A,Skalicky M

doi

10.1007/BF03327370

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

475-81

issue

6

eissn

1594-0667

issn

1720-8319

journal_volume

15

pub_type

杂志文章

相关文献

AGING CLINICAL AND EXPERIMENTAL RESEARCH文献大全
  • Familial late-onset Alzheimer's disease: description of an Italian family with four affected siblings and one case of early-onset dementia in the preceding generation.

    abstract：:We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-015-0383-7

    authors： Abbate C,Arosio B,Cantatore A,Viti N,Giunco F,Bagarolo R,Nicolini P,Gussago C,Ferri E,Casati M,Rossi PD,Casè A,Bergamaschini L,Vergani C,Mari D

    更新日期：2016-10-01 00:00:00

  • A Nordic multi-center study on physical and daily activities for residents in nursing home settings: design of a randomized, controlled trial.

    abstract：BACKGROUND AND AIMS:Nursing home residents constitute a frail, multi-diseased and heterogeneous group. As physical activity is essential for the preservation of function, personalized training and activities are of great importance. The main objective of this study was to describe the influence of an individually tailo...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF03324921

    authors： Frändin K,Borell L,Grönstedt H,Bergland A,Helbostad JL,Puggaard L,Andresen M,Granbo R,Hellström K

    更新日期：2009-08-01 00:00:00

  • Effects of participatory art-based painting workshops in geriatric inpatients: results of a non-randomized open label trial.

    abstract：BACKGROUND:Art-based activities like painting workshops demonstrated health benefits in older individuals living in home care facilities. Few studies examined the effects of painting workshops in geriatric inpatients. AIM:The study aims to examine whether the participation in painting workshops performed in patients a...

    journal_title：Aging clinical and experimental research

    pub_type： 临床试验,杂志文章

    doi：10.1007/s40520-020-01675-0

    authors： Beauchet O,Lafleur L,Remondière S,Galery K,Vilcocq C,Launay CP

    更新日期：2020-12-01 00:00:00

  • Prevention of the spread of multidrug-resistant organisms in nursing homes.

    abstract：:The increase in the aged population led to a global rise in the demand for elderly healthcare services, such as long-term care facilities (LTCFs), nursing homes, residential homes. Unfortunately, the spread of multidrug-resistant organisms (MDROs) in these structures represent an urgent public health threat requiring ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-020-01746-2

    authors： Tinelli M,Tiseo G,Falcone M,ESCMID Study Group for Infections in the Elderly.

    更新日期：2021-01-11 00:00:00

  • Health status in the oldest old. Age and sex differences in the Umeå 85+ Study.

    abstract：BACKGROUND AND AIMS:With an increasing population aged 85 years and over, the aim of this study was to describe health status and living conditions in the oldest old and to estimate age and sex differences in a Northern European population. METHODS:A population-based cross-sectional study, The Umeå 85+ Study, was carr...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03327426

    authors： von Heideken Wågert P,Gustavsson JM,Lundin-Olsson L,Kallin K,Nygren B,Lundman B,Norberg A,Gustafson Y

    更新日期：2006-04-01 00:00:00

  • Comparing the influence of exercise intensity on brain-derived neurotrophic factor serum levels in people with Parkinson's disease: a pilot study.

    abstract：INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a p...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-019-01353-w

    authors： O'Callaghan A,Harvey M,Houghton D,Gray WK,Weston KL,Oates LL,Romano B,Walker RW

    更新日期：2020-09-01 00:00:00

  • Effects of a physical activity program on postural stability in older people.

    abstract：BACKGROUND AND AIMS:The objective of this non-randomized study was to determine the influence of a specific physical activity program on the postural stability of older people. METHODS:Seventy-four subjects (72.4 +/- 0.7 yrs) participated in an individualized three-month physical activity program designed to improve p...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324564

    authors： Hue OA,Seynnes O,Ledrole D,Colson SS,Bernard PL

    更新日期：2004-10-01 00:00:00

  • Educational vaccine tools: the French initiative.

    abstract：:Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324906

    authors： Belmin J,Bourée P,Camus D,Guiso N,Jeandel C,Trivalle C,Veyssier P

    更新日期：2009-06-01 00:00:00

  • Age-associated changes in hand grip and quadriceps muscle strength ratios in healthy adults.

    abstract：BACKGROUND AND AIMS:Muscle strength may decline with age differentially in the upper and lower limbs. This information is difficult to capture through a single measure. The present study therefore aimed to characterize the relative changes in handgrip and lower limb muscle strength with aging by expressing them as a ra...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03325252

    authors： Samuel D,Wilson K,Martin HJ,Allen R,Sayer AA,Stokes M

    更新日期：2012-06-01 00:00:00

  • The contribution of CNVs to the most common aging-related neurodegenerative diseases.

    abstract：:Alzheimer and Parkinson's diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address these complex multifactorial traits, a systems biolog...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-020-01485-4

    authors： Gentile G,La Cognata V,Cavallaro S

    更新日期：2020-02-06 00:00:00

  • A combined stepping and visual tracking task predicts cognitive decline in older adults better than gait or visual tracking tasks alone: a prospective study.

    abstract：BACKGROUND:It is unclear whether motor-cognitive dual tasks predict cognitive decline better than either motor or cognitive tasks alone. AIMS:To examine the utility of the novel motor-cognitive dual-task test [Stepping Trail Making Test (S-TMT)], as a predictor of cognitive decline, and compare its predictive performa...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-020-01714-w

    authors： Osuka Y,Kim H,Watanabe Y,Taniguchi Y,Kojima N,Seino S,Kawai H,Sakurai R,Inagaki H,Awata S,Shinkai S

    更新日期：2020-09-23 00:00:00

  • Acetylcholinesterase inhibitors and depressive symptoms in patients with mild to moderate Alzheimer's disease.

    abstract：BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324693

    authors： Rozzini L,Vicini Chilovi B,Bertoletti E,Trabucchi M,Padovani A

    更新日期：2007-06-01 00:00:00

  • Quality of life in sarcopenia measured with the SarQoL®: impact of the use of different diagnosis definitions.

    abstract：BACKGROUND:The SarQoL® is a recently developed quality of life questionnaire specific to sarcopenia. AIM:To compare the quality of life (QoL) of subjects identified as sarcopenic with that of non-sarcopenic subjects when using six different operational definitions of sarcopenia. METHODS:Participants of the SarcoPhAge...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-017-0866-9

    authors： Beaudart C,Locquet M,Reginster JY,Delandsheere L,Petermans J,Bruyère O

    更新日期：2018-04-01 00:00:00

  • Prevention of falls and role of calcium and vitamin D.

    abstract：:Falls in the elderly are very common and represent a serious cause of morbidity, severe disability and death. Impairments of the mechanisms of postural stability with age and the presence of acute and chronic diseases may favour the occurrence of falls in the elderly. Together with the adoption of non-pharmacological ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：

    authors： Gatto S,Gimigliano F,Gimigliano R,Iolascon G

    更新日期：2011-04-01 00:00:00

  • Pattern of use and presenting complaints of older patients visiting an Emergency Department in Italy.

    abstract：BACKGROUND AND AIMS:The number of older persons admitted to the Emergency Department (ED) is dramatically increasing due to their complex medical and social problems, which in turn lead to longer clinical evaluation times and increased use of resources compared to younger adults. However, scant data are available for I...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-013-0112-z

    authors： Salvi F,Mattioli A,Giannini E,Vita D,Morichi V,Fallani M,Dessì-Fulgheri P,Cherubini A

    更新日期：2013-10-01 00:00:00

  • Aging-related changes in oxidative stress response of human endothelial cells.

    abstract：BACKGROUND:Oxidative stress is strongly associated with aging and age-related diseases and plays a crucial role in endothelial dysfunction development. AIM:To better understand the molecular mechanisms of aging and stress response in humans, we examined changes to young and older human endothelial cells over time (72,...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-015-0357-9

    authors： Conti V,Corbi G,Simeon V,Russomanno G,Manzo V,Ferrara N,Filippelli A

    更新日期：2015-08-01 00:00:00

  • Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia.

    abstract：OBJECTIVE:The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS:The cognitive functions of 98 elderly patients who were scheduled t...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-015-0519-9

    authors： Xie H,Huang D,Zhang S,Hu X,Guo J,Wang Z,Zhou G

    更新日期：2016-12-01 00:00:00

  • Vitamin D receptor polymorphisms, bone ultrasound and mineral density in post-menopausal women.

    abstract：BACKGROUND AND AIMS:Bone structure, geometry and mineral content represent complex traits with a significant heritable component. However, the specific contributing genes have not been unambiguously identified. The aim of the present cross-sectional study was to analyse an association between heel ultrasound measuremen...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324584

    authors： Zajickova K,Zofkova I,Hill M

    更新日期：2005-04-01 00:00:00

  • Relationship of a lifelong physical workload with physical function and low back pain in retired women.

    abstract：BACKGROUND AND AIMS:The effect of heavy work-related physical loads (WRPL) on low back pain (LBP) and impaired physical function has been studied extensively in active workers but not in pensioners. METHODS:We compared LBP and physical function in post-menopausal pensioners, divided according to their life-long WRPL i...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324899

    authors： Gnudi S,Sitta E,Gnudi F,Pignotti E

    更新日期：2009-02-01 00:00:00

  • Drugs and falls in older people in geriatric care settings.

    abstract：BACKGROUND AND AIMS:Falls and their consequences constitute serious health problems in the older population. The aim was to study predisposing factors for falls among older people in geriatric care settings, focusing on drugs. METHODS:This population-based study, with a cross-sectional design, analysed all geriatric c...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03324551

    authors： Kallin K,Gustafson Y,Sandman PO,Karlsson S

    更新日期：2004-08-01 00:00:00

  • Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease.

    abstract：BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/BF03351076

    authors： Galizia G,Cacciatore F,Testa G,Della-Morte D,Mazzella F,Langellotto A,Raucci C,Gargiulo G,Ferrara N,Rengo F,Abete P

    更新日期：2011-04-01 00:00:00

  • Significance and clinical applications of ultrasound score in assessing the clinical severity of acute cholecystitis in the elderly.

    abstract：OBJECTIVE:To investigate the feasibility and significance of the clinical application of ultrasound score in assessing the clinical severity of acute cholecystitis in the elderly. METHODS:Pre-surgery ultrasonography was performed on 72 elderly patients with acute cholecystitis who were scheduled for cholecystectomy to...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-014-0236-9

    authors： Zhang L,Han Q,Zhang H,Li D,Yao K

    更新日期：2015-02-01 00:00:00

  • A prevalence study of potentially inappropriate medications use in hospitalized Pakistani elderly.

    abstract：BACKGROUND:Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS:To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the facto...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-017-0742-7

    authors： Mazhar F,Akram S,Malhi SM,Haider N

    更新日期：2018-01-01 00:00:00

  • Strength training and protein supplementation improve muscle mass, strength, and function in mobility-limited older adults: a randomized controlled trial.

    abstract：BACKGROUND:Adaptation to strength training in very old mobility-limited individuals is not fully characterized. Therefore, the aim of this study was to perform a thorough investigation of the adaptation to a lower body strength training regime in this population, with particular emphasis on the relationship between cha...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40520-019-01234-2

    authors： Aas SN,Seynnes O,Benestad HB,Raastad T

    更新日期：2020-04-01 00:00:00

  • Validity of the interRAI Acute Care based on test content: a multi-center study.

    abstract：BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,多中心研究

    doi：10.1007/BF03325244

    authors： Wellens NI,Deschodt M,Boonen S,Flamaing J,Gray L,Moons P,Milisen K

    更新日期：2011-10-01 00:00:00

  • Platelet-to-lymphocyte ratio relates to poor prognosis in elderly patients with acute myocardial infarction.

    abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients. AIM:The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events. METHODS:A total o...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-020-01555-7

    authors： Li L,Ma Y,Geng XB,Tan Z,Wang JH,Cui C,Wang HL,Shang XM

    更新日期：2020-04-16 00:00:00

  • Clinically silent idiopathic Parkinson's disease unmasked by valproate use: a brief report.

    abstract：:Valproate is an important but uncommon cause of drug induced parkinsonism in the elderly. The development of symptoms after valproate onset is unpredictable, and severity of symptoms is unrelated to plasma levels. However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：10.1007/s40520-014-0278-z

    authors： Athauda D,Batley R,Ellis C

    更新日期：2015-06-01 00:00:00

  • Biomarkers for physical frailty and sarcopenia.

    abstract：:Physical frailty (PF) and sarcopenia are major health issues in geriatric populations, given their high prevalence and association with several adverse outcomes. Nevertheless, the lack of an univocal operational definition for the two conditions has so far hampered their clinical implementation. Existing definitional ...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-016-0708-1

    authors： Calvani R,Marini F,Cesari M,Tosato M,Picca A,Anker SD,von Haehling S,Miller RR,Bernabei R,Landi F,Marzetti E,SPRINTT Consortium.

    更新日期：2017-02-01 00:00:00

  • Nutrition, osteoarthritis and cartilage metabolism.

    abstract：BACKGROUND:Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some r...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章,评审

    doi：10.1007/s40520-019-01191-w

    authors： Messina OD,Vidal Wilman M,Vidal Neira LF

    更新日期：2019-06-01 00:00:00

  • Diabetes in a geriatric ward: efficacy and safety of new insulin analogs in very old inpatients.

    abstract：AIMS:1) to evaluate the prevalence of diabetes mellitus (DM) in a geriatric ward; 2) to assess the efficacy and safety of insulin analogs in elderly inpatients over 65 years of age. METHODS:We analysed the medical records of 1851 elderly inpatients admitted to our geriatric clinic from March 2009 to September 2011, to...

    journal_title：Aging clinical and experimental research

    pub_type： 杂志文章

    doi：

    authors： Franchin A,Corradin ML,Giantin V,Rossi F,Zanatta F,Attanasio F,Toffanello ED,Manzato E

    更新日期：2012-06-01 00:00:00