Abstract：
PURPOSE:To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX®) as well as whether TBS can improve the fracture prediction ability of FRAX® in diabetic women. METHODS:Eighty diabetic postmenopausal women were matched with 88 controls without major diseases for age and body mass index. The individual 10-year fracture risk was assessed by FRAX® tool for Europe-Italy; bone mineral density (BMD) at lumbar spine, femoral neck and total hip was evaluated through dual-energy X-ray absorptiometry; TBS measurements were taken using the same region of interest as the BMD measurements; HSA was performed at proximal femur with the HSA software. RESULTS:Regarding variables of interest, the only significant difference between diabetic and control groups was observed for the value of TBS (median value: 1.215; IQR 1.138-1.285 in controls vs. 1.173; IQR 1.082-1.217 in diabetic; p = 0.002). The prevalence of fractures in diabetic women was almost tripled than in controls (13.8 vs. 3.4 %; p = 0.02). The receiver operator characteristic curve analysis showed that TBS alone (AUC = 0.71) had no significantly lower discriminative power for fracture prediction in diabetic women than FRAX major adjusted for TBS (AUC = 0.74; p = 0.65). CONCLUSION:In diabetic postmenopausal women TBS is an excellent tool in identifying fragility fractures.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Bonaccorsi G,Fila E,Messina C,Maietti E,Ulivieri FM,Caudarella R,Greco P,Guglielmi Gdoi
10.1007/s40520-016-0634-2subject
Has Abstractpub_date
2017-10-01 00:00:00pages
951-957issue
5eissn
1594-0667issn
1720-8319pii
10.1007/s40520-016-0634-2journal_volume
29pub_type
杂志文章abstract：BACKGROUNDS:Different and new approaches have been proposed to prevent the risk of falling of elderly people, particularly women. AIMS:This study investigates the possibility that a new protocol based on the focal mechanical muscle vibration may reduce the risk of falling of elderly women. METHODS:A pragmatic randomi...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40520-015-0356-x
更新日期：2015-12-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-020-01518-y
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abstract：BACKGROUND AND AIMS:The success of I-131 therapy in geriatric patients who were referred to an endocrinology clinic with toxic nodular goiter and who lived in iodine-deficiency regions was studied. MATERIALS AND METHODS:Patients older than 60 years who received I-131 therapy were included via retrospective data analys...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/8759
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abstract：:Senescence of the brain seems to be related to increased levels of free oxygen radical (FOR). FOR may damage macromolecular compounds such as: proteins, lipids, and DNA. In the aging brain, increased FOR levels damage DNA, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA). In DNA they damage single and double strands,...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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abstract：BACKGROUND AND AIMS:Although many older persons choose to postpone retirement, the health consequences of this decision are still debated. This study aimed at determining the impact of continued employment on life-style, well-being, health and survival in a cohort of community-dwelling 70-year-olds. METHODS:A longitud...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03327419
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abstract：:The most frequent indication for Calcium Channel Blockers (CCBs) is their use as antihypertensive agents for primary or secondary stroke prevention. Hypertension contributes to virtually all mechanisms of stroke, of atherothrombotic, lacunar, cardioembolic and intraparenchymal hemorrhage types. In comparison with the ...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
doi：
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/BF03325209
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journal_title：Aging clinical and experimental research
pub_type： 临床试验,杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,评审
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Fall-induced deaths of elderly people are a major problem. AIM AND METHODS:Using the Official Cause-of-Death Statistics of Finland, we aimed to determine the current trends in the number and age-adjusted incidence (per 100,000 persons) of fall deaths among older Finns by taking into account 50 years or olde...
journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.1007/s40520-018-0898-9
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,meta分析
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更新日期：2012-12-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章,随机对照试验
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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journal_title：Aging clinical and experimental research
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Aging clinical and experimental research
pub_type： 杂志文章
doi：10.3275/7519
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