Abstract:
:The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed. Cyclocariols A-H were evaluated for their cytotoxicities against human liver (SMMC-7721) and breast cancer (BT-549) cell lines. Cyclocariols A, B, E, and H were also tested against human colon tumor (HCT-116) cell lines, where all four exhibited good activities with IC50 values of 6.53, 4.94, 8.24, and 6.48 μM, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Chen YJ,Na L,Fan J,Zhao J,Hussain N,Jian YQ,Yuan H,Li B,Liu B,Choudhary MI,Khan I,Wang Wdoi
10.1016/j.phytochem.2017.10.013subject
Has Abstractpub_date
2018-01-01 00:00:00pages
85-92eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30339-4journal_volume
145pub_type
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