Abstract:
:A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
el-Mekkawy S,Meselhy MR,Nakamura N,Tezuka Y,Hattori M,Kakiuchi N,Shimotohno K,Kawahata T,Otake Tdoi
10.1016/s0031-9422(98)00254-4subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1651-7issue
6eissn
0031-9422issn
1873-3700pii
S0031-9422(98)00254-4journal_volume
49pub_type
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