Abstract:
:Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32.42-62.90 μM. Only compound 1 had in vitro cytotoxic activity against Bcap37 cells, with the IC50 value of 90.61 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Ge YC,Zhang HJ,Wang KW,Fan XFdoi
10.1016/j.phytochem.2018.06.017subject
Has Abstractpub_date
2018-10-01 00:00:00pages
73-76eissn
0031-9422issn
1873-3700pii
S0031-9422(18)30274-7journal_volume
154pub_type
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