Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China.

Abstract:

:Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32.42-62.90 μM. Only compound 1 had in vitro cytotoxic activity against Bcap37 cells, with the IC50 value of 90.61 μM.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Ge YC,Zhang HJ,Wang KW,Fan XF

doi

10.1016/j.phytochem.2018.06.017

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

73-76

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(18)30274-7

journal_volume

154

pub_type

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