Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.

Abstract:

:The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Morikawa T,Xie Y,Asao Y,Okamoto M,Yamashita C,Muraoka O,Matsuda H,Pongpiriyadacha Y,Yuan D,Yoshikawa M

doi

10.1016/j.phytochem.2009.06.015

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1166-1172

issue

9

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(09)00252-0

journal_volume

70

pub_type

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