Cytotoxic heterodimers of meroterpene phenol from the fruits of Psoralea corylifolia.

Abstract:

:Seventeen undescribed heterodimers of meroterpene phenol, psocorylins A-Q, were isolated from the fruits of Psoralea corylifolia. Their another monomeric unit derived from flavonone, chalcone, coumarin and isoflavone, respectively. Psocorylins A-E were rare natural spiroketals with the skeleton of 1,4,8-trioxaspiro[4.5]decane deriving from flavonone, and their plausible biosynthetic pathways were proposed. These structures were established by spectroscopic methods. Their absolute configurations were assigned via single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations and Rh2(OCOCF3)4-induced ECD spectra. Psocorylins B-E, F, M and Q exhibited potent cytotoxic activities against different kinds of tumor cells with IC50 values less than 10 μM.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Xu QX,Zhang YB,Liu XY,Xu W,Yang XW

doi

10.1016/j.phytochem.2020.112394

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

112394

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(19)31244-0

journal_volume

176

pub_type

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