Abstract：
:Five undescribed xanthones, 4-methoxypyranojacareubin, 4-hydroxy-3-prenylpyranoxanthone, 1-hydroxy-5,7-dimethoxyxanthone, 5-hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone, together with thirty-three known xanthones were isolated from the roots of Mesua ferrea L. The structures of all isolated xanthones were elucidated based on spectroscopic methods. 5-Hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone were also confirmed by X-ray diffraction data. In addition, the isolated compounds were determined for antibacterial, antioxidant and cytotoxic activities. The known 1,5,6-trihydroxyxanthone showed cytotoxicity against A375, PC-3 and HaCaT cell lines with IC50 values of 5.73 μg/mL, 5.93 μg/mL and 8.94 μg/mL, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Chukaew A,Saithong S,Chusri S,Limsuwan S,Watanapokasin R,Voravuthikunchai SP,Chakthong Sdoi
10.1016/j.phytochem.2018.10.008subject
Has Abstractpub_date
2019-01-01 00:00:00pages
64-70eissn
0031-9422issn
1873-3700pii
S0031-9422(18)30634-4journal_volume
157pub_type
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