Abstract:
:Contemporary glycobiology reflects the intense interest in glycoproteins and their biological roles. Addition of saccharides by N- or O-glycosylation is precise rather than random and forms a uniquely interactive molecular surface. We designate these well conserved glycomotifs as glycomodules to emphasize their functional significance. Thus, elucidation of the glycosylation codes that determine saccharide addition is a significant goal. The focus here is on the Hyp O-glycosylation of cell wall proteins. This involves two consecutive posttranslational modifications, proline hydroxylation and glycosylation. Peptide sequence rather than conformation seems to determine these modifications. Hyp glycosylation occurs in two distinct modes: Hyp arabinosylation and Hyp galactosylation. The Hyp contiguity hypothesis predicts arabinosylation of contiguous Hyp residues and galactosylation of clustered non-contiguous Hyp. Elucidation of Hyp glycosylation codes involves the design and expression of putative glycomotifs as simple repetitive peptides. Thus, repetitive (Ser-Hyp), directed Hyp galactosylation resulting in the exclusive addition of arabinogalactan polysaccharide to all the non-contiguous Hyp residues. and a new AGP. Another repetitive peptide from gum arabic glycoprotein, containing both contiguous and non-contiguous Hyp, directed both modes of Hyp glycosylation. Furthermore, expression of the (Ser-Hypx)n series confirmed the arabinosylation of contiguous Hyp. Thus, the Hyp contiguity hypothesis is a useful predictive tool in the functional genomics toolbox.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Kieliszewski MJdoi
10.1016/s0031-9422(01)00029-2subject
Has Abstractpub_date
2001-06-01 00:00:00pages
319-23issue
3eissn
0031-9422issn
1873-3700pii
S0031-9422(01)00029-2journal_volume
57pub_type
杂志文章,评审相关文献
PHYTOCHEMISTRY文献大全abstract::A new anthraquinone glycoside, emodin-6-O-beta-D-glucopyranoside, and a new simple halogenated flavan-3-ol, 6-chlorocatechin, have been isolated from the roots of Rumex patientia L. together with seven known phenolic compounds. Their structures were elucidated on the basis of spectroscopic methods. Cytotoxic effects a...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(01)00337-5
更新日期:2001-12-01 00:00:00
abstract::A pyrroloisoquinoline alkaloid, 2,3-dimethoxy-6-(3-oxo-butyl)-7,9,10,11,11a,12-hexahydrobenzo[f]pyrrolo[1,2-b]isoquinoline (1), whose structure was determined by spectroscopic methods, was isolated from the aerial parts of Cynanchum komarovii, together with two known alkaloids, 7-demethoxytylophorine (2) and 7-demetho...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(01)00382-x
更新日期:2001-12-01 00:00:00
abstract::Novel, polyunsaturated monocyclic sester- and triterpenes isolated from the diatom Rhizosolenia setigera (Brightwell), are biosynthesised mainly via the mevalonate pathway. The experiments involved incubation of the alga with [1-(13)C]acetate, isolation of the alkenes by extraction and silver ion HPLC, followed by det...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2004.02.019
更新日期:2004-04-01 00:00:00
abstract::Phenylpropanoid glycosides, 1'-O-benzyl-alpha-L-rhamnopyranosyl-(1''-->6')-beta-D-glucopyranoside (1) and alpha-L-xylopyranosyl-(4''-->2')-(3-O-beta-D-glucopyranosyl)-1'-O-E-caffeoyl-beta-D-glucopyranoside (2), together with the known derivatives, 1,6-di-O-caffeoyl-beta-D-glucopyranoside (3), 1-O-(E)-caffeoyl-beta-D-g...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2005.06.019
更新日期:2005-08-01 00:00:00
abstract::A new acylated anthocyanin was isolated from the red-purple flowers of x Laeliocattleya cv Mini Purple as one of the major anthocyanins. The structure of this pigment was determined to be cyanidin 3-O-[6-O-(malonyl)-beta-D-glucopyranoside]-7-O-[6-O-(trans-p- coumaryl)-beta-D-glucopyranoside]-3'-O-[6-O-[trans-4-O-[6-O-...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(00)89553-9
更新日期:1994-11-01 00:00:00
abstract::Visible symptoms of tepal senescence in cut Iris x hollandica (cv. Blue Magic) flowers were delayed by placing one cut daffodil flower (Narcissus pseudonarcissus, cv. Carlton) in the same vase. Addition of mucilage, exuded by daffodil stems, to the vase water had the same effect as the flowering daffodil stem. The act...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2003.12.008
更新日期:2004-03-01 00:00:00
abstract::Fractionation of an HIV-inhibitory organic extract of Geniostoma antherotrichum afforded a glycoside derivative, which has been characterized as 2-hydroxy-3-O-beta-D-glucopyranosyl-benzoic acid (1) on the basis of spectral analyses. The HIV-inhibitory activity of the extract was traced to polymeric tannins, while 1 wa...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/0031-9422(95)00768-7
更新日期:1996-03-01 00:00:00
abstract::Biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus AS 3.3450 gave 10 metabolites (2-10), of which 2-5 were previously known. On the basis of NMR and MS analyses, structures 6-10 were established as 12-oxo-23beta-hydroxyl-20(S)-protopanaxatriol (6), 20S,24R-epoxy-dammaran-3beta,6alpha,25-triol...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2007.05.028
更新日期:2007-10-01 00:00:00
abstract::The ubiquitous glycolipid 1,2-dilinolenoyl-3-galactopyranosylglycerol and a new protolimonoid glucoside, named prieurianoside, were isolated from the leaves of Trichilia prieuriana. The structure of the latter was established, by spectroscopic techniques, as 12beta,21-diacetoxy-29-beta-D-glucopyranosyloxy-23zeta -hydr...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(99)00374-x
更新日期:2000-08-01 00:00:00
abstract::Nine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racemates. The structures and...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2019.04.012
更新日期:2019-08-01 00:00:00
abstract::The distribution and biosynthesis of iridoid glucosides in the Oleaceae is reviewed and five distinct biosynthetic pathways to iridoids have been identified in the family, deoxyloganic acid apparently being a common intermediate. Likewise, the distributions of caffeoyl phenylethanoid glycosides (CPGs), i.e. verbascosi...
journal_title:Phytochemistry
pub_type: 杂志文章,评审
doi:10.1016/s0031-9422(02)00102-4
更新日期:2002-06-01 00:00:00
abstract::A series of prenylated flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2017.06.003
更新日期:2017-09-01 00:00:00
abstract::The linear hexitol altritol has only been identified in six genera, all of them in the order Fucales of the brown algae. Five of these genera are closely related according to molecular phylogenetic and other data, while the sixth (Notheia) is an obligate epiphyte on two other altritol-containing genera with which it i...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(01)00286-2
更新日期:2001-10-01 00:00:00
abstract::Three acylated flavonol glycosides have been identified from leaves of Planchonia grandis Ridley. They possess kaempferol as aglycone and two triglycosidic chains substituting hydroxyl groups at the 3- and 7-positions. The first glycosidic unit of each chain is esterified by a cis or trans p-coumaric acid. Structural ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(03)00215-2
更新日期:2003-09-01 00:00:00
abstract::In search for new or chemo-taxonomically relevant bioactive compounds from chemically unexplored Hypericum species, four previously undescribed natural products, named peplidiforones A-D were isolated and characterized from Hypericum peplidifolium A. Rich., together with six known compounds. The structures of all comp...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2016.02.003
更新日期:2016-04-01 00:00:00
abstract::S-limonene synthase is a model monoterpene synthase that cyclizes geranyl pyrophosphate (GPP) to form S-limonene. It is a relatively specific enzyme as the majority of its products are composed of limonene. In this study, we converted it to pinene or phellandrene synthases after introducing N345A/L423A/S454A or N345I ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2017.02.017
更新日期:2017-05-01 00:00:00
abstract::Triterpenoid saponins, impatienosides A-G, together with 12 known saponins, were isolated from the whole plants of Impatiens siculifer. Their structures were established on the basis of extensive 1D and 2D NMR and MS analyses coupled with chemical degradation. Cytotoxic activities of the isolated saponins were evaluat...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2009.03.022
更新日期:2009-04-01 00:00:00
abstract::A combination of high-resolution mass spectrometry and modern HPLC column technology, assisted by diode array detection, was used for accurate characterization of water-soluble polyphenolic compounds in the pistils, stamens, petals, sepals, stems, leaves, roots and seeds of Geranium sylvaticum. The organs contained a ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2013.05.013
更新日期:2013-11-01 00:00:00
abstract::Highly specialized chemical defense pathways are a particularly noteworthy metabolic characteristic of sessile organisms, whether terrestrial or marine, providing protection against pests and diseases. For this reason, knowledge of the metabolites involved in these processes is crucial to producing ecologically fit cr...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2014.07.024
更新日期:2015-05-01 00:00:00
abstract::Two new flavanone glycosides, alhagitin and alhagidin, have been isolated from the whole plant of Alhagi pseudalhagi and their structures established respectively as naringenin 5-methyl ether 4'-glucoside and hesperitin 7-galactosyl(1-->2)[rhamnosyl(1-->6)]glucoside by chemical and spectroscopic methods. ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(99)00010-2
更新日期:1999-06-01 00:00:00
abstract::The widespread secondary metabolite usnic acid, a dibenzofuran derivative, is the principal acetone-soluble compound in the lichen Flavocetraria nivalis. Seasonal variation in concentrations were studied in four populations of this lichen, three from Arctic-alpine habitats in the Northern Hemisphere, and one from Pata...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2004.12.007
更新日期:2005-02-01 00:00:00
abstract::A new flavonol tetraglycoside, together with two known flavonol glycosides, kaempferol 7-rhamnoside and kaempferol 3-rhamnosyl(1-->6) galactoside-7-rhamnoside, were isolated from fresh plant material of Cephalocereus senilis. The structure of the new compound was established as kaempferol 3-O-beta-D-glucopyranosyl(1--...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(00)97043-2
更新日期:1994-05-01 00:00:00
abstract::Bacterial LPS have the ability to act as modulators of the innate immune response in plants. Complex and largely unresolved perception systems exist for LPS on the plant cell surfaces that lead to the activation of multiple intracellular defense signaling pathways. The aim of the present study was to investigate the p...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2004.09.005
更新日期:2004-11-01 00:00:00
abstract::Seven hexahydrobenzophenanthridine-type alkaloids, Ambiguanine A-G, along with eight known alkaloids, were isolated from tubers of Corydalis ambigua var. amurensis. Their structures were elucidated based on extensive spectroscopic analyses, with absolute configurations determined by CD experiments. ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2014.05.013
更新日期:2014-09-01 00:00:00
abstract::The antifungal glycoalkaloid alpha-tomatine of the tomato plant (Lycopersicon esculentum) is proposed to protect the plant against phytopathogenic fungi. Fusarium oxysporum f. sp. lycopersici, a vascular pathogen of tomato, produces a tomatinase enzyme which hydrolyses the glycoalkaloid into non-fungitoxic compounds. ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(97)00170-2
更新日期:1997-08-01 00:00:00
abstract::Sugarcane neutral invertase (SNI) has been partially purified from mature sugarcane stem tissue to remove any potential competing activity. The enzyme is non-glycosylated and exhibits catalytic activity as a monomer, dimer and tetramer, most of the activity elutes as a monomer of native M(r) ca 60 k. The enzyme displa...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(98)00204-0
更新日期:1998-10-01 00:00:00
abstract::Aconitum carmichaelii has long been used as a traditional Chinese medicine, and its processed lateral roots are known commonly as fuzi. Aconitine-type C19-diterpenoid alkaloids accumulating in the lateral roots are some of the main toxicants of this species, yet their biosynthesis remains largely unresolved. As a firs...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2018.04.022
更新日期:2018-08-01 00:00:00
abstract::8-dimethylallylnaringenin (8-DMAN) 2'-hydroxylase, which is indispensable for the formation of a lavandulylated flavanone, sophoraflavanone G, was detected in cell suspension cultures of Sophora flavescens. The enzyme catalyzes the 2'-hydroxylation of 8-DMAN to leachianone G, and is tightly bound to the membrane. It r...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(01)00270-9
更新日期:2001-11-01 00:00:00
abstract::A new bidesmosidic triterpenoidal saponin 3-O-[beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->4)-alpha-L - arabinopyranosyl]-hederagenin-28-O-[alpha-L-rhamnopyranosyl- (1-->4)-beta-D- glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester, was isolated from the roots of Symphytum officinale. The structure was a...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/0031-9422(95)00246-4
更新日期:1995-09-01 00:00:00
abstract::Five previously undescribed monoterpenoid indole alkaloids were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated by HRESIMS, X-ray diffraction, ECD spectra, and molecular modeling. 19,20-Epoxyhumantenine is a humantenine-type alkaloid with an epoxypropyl group...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2019.03.016
更新日期:2019-06-01 00:00:00