Abstract:
:Nine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racemates. The structures and absolute configurations of the undescribed compounds were determined by comprehensive MS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. The cytotoxic effects of the isolated compounds on two human tumour cell lines (HEL and MDA-MB-231) were evaluated by the MTT assay. Eighteen compounds showed good inhibitory activities against the HEL cell line, with IC50 values of 3.53-18.7 μM, while nine compounds exhibited moderate cytotoxicity against the MDA-MB-231 cancer cell line, with IC50 values ranging from 4.92 to 10.75 μM. Their preliminary structure-activity relationship of the isolated compounds was also discussed.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Zhu W,Qiu J,Zeng YR,Yi P,Lou HY,Jian JY,Zuo MX,Duan L,Gu W,Huang LJ,Li YM,Yuan CM,Hao XJdoi
10.1016/j.phytochem.2019.04.012subject
Has Abstractpub_date
2019-08-01 00:00:00pages
33-40eissn
0031-9422issn
1873-3700pii
S0031-9422(19)30038-Xjournal_volume
164pub_type
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