Hepatoprotective pyranocoumarins from the stems of Clausena emarginata.

Abstract:

:Seven pyranocoumarins, clauemarmarins A-G, along with 6 known analogues were isolated from the stems of Clausena emarginata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute stereochemistries at C-6″ of clauemarmarin B, C and D and the absolute configurations of clauemarmarin E, F and G were determined by ECD experiments. Compounds clauemarmarin C, D and two known analogues exhibited hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells at the concentration of 10 μM.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Xia HM,Li CJ,Yang JZ,Ma J,Li Y,Li L,Zhang DM

doi

10.1016/j.phytochem.2016.05.010

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

238-43

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(16)30112-1

journal_volume

130

pub_type

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