Abstract：
:Chemical investigation of the methanol extract of the fertile form of Roccella montagnei collected in Vietnam afforded twelve secondary metabolites, including five new montagnetol derivatives, orsellinylmontagnetols A-D and a furanyl derivative together with seven known compounds. Their chemical structures were elucidated by analysis of 1D and 2D NMR and high resolution mass spectroscopic data. The relative stereochemistry of two chiral centers (C-2 and C-3) of orsellinylmontagnetols A and B was elucidated by comparison of their coupling constants and the specific rotation with those reported in the literature while the absolute stereochemistry was determined by the application of a modified Mosher method for the hydroxy group at C-3. The absolute configuration (2R,3S) of the butanetetraol moiety of these compounds is in accordance with that of erythrin, a recognized chemotaxonomic marker of the genus Roccella. Five of these compounds were evaluated for their cytotoxic activities against four cancer cell lines. Only orsellinylmontagnetol A exerted a moderate activity against MCF-7 cell line with an IC50 value of 68.39 ± 3.46 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Duong TH,Huynh BLC,Chavasiri W,Chollet-Krugler M,Nguyen VK,Nguyen THT,Hansen PE,Le Pogam P,Thüs H,Boustie J,Nguyen KPPdoi
10.1016/j.phytochem.2017.02.012subject
Has Abstractpub_date
2017-05-01 00:00:00pages
156-164eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30054-7journal_volume
137pub_type
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