Abstract:
:Eight pairs of meroterpenoid enantiomers and four achiral meroterpenoids were isolated from Rhododendron anthopogonoides Maxim. Seventeen of them, named (+)-/(-)-anthoponoids A-G, (+)-daurichromene D, and anthoponoids H and I, are undescribed compounds with structural diversity. Their structures were characterized herein by a combined application of spectroscopic techniques, X-ray crystallographic analysis, ECD calculation, and the modified Mosher's method. (+)-/(-)-Anthoponoid A and anthoponoid I are the first Rhododendron meroterpenoids found to possess a hexahydroxanthene motif and a diterpene unit, respectively. Some isolates were identified as NF-κB pathway inhibitors, and (+)-anthoponoid E, (-)-anthoponoid G, and anthoponoid H showed suppressive effects on LPS-induced inflammatory responses in RAW 264.7 macrophages.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Shi Q,Li TT,Wu YM,Sun XY,Lei C,Li JY,Hou AJdoi
10.1016/j.phytochem.2020.112524subject
Has Abstractpub_date
2020-12-01 00:00:00pages
112524eissn
0031-9422issn
1873-3700pii
S0031-9422(20)31139-0journal_volume
180pub_type
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