Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides.

Abstract:

:Eight pairs of meroterpenoid enantiomers and four achiral meroterpenoids were isolated from Rhododendron anthopogonoides Maxim. Seventeen of them, named (+)-/(-)-anthoponoids A-G, (+)-daurichromene D, and anthoponoids H and I, are undescribed compounds with structural diversity. Their structures were characterized herein by a combined application of spectroscopic techniques, X-ray crystallographic analysis, ECD calculation, and the modified Mosher's method. (+)-/(-)-Anthoponoid A and anthoponoid I are the first Rhododendron meroterpenoids found to possess a hexahydroxanthene motif and a diterpene unit, respectively. Some isolates were identified as NF-κB pathway inhibitors, and (+)-anthoponoid E, (-)-anthoponoid G, and anthoponoid H showed suppressive effects on LPS-induced inflammatory responses in RAW 264.7 macrophages.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Shi Q,Li TT,Wu YM,Sun XY,Lei C,Li JY,Hou AJ

doi

10.1016/j.phytochem.2020.112524

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

112524

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(20)31139-0

journal_volume

180

pub_type

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