Abstract:
:A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'',3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR (1)H-(1)H COSY and (13)C-(1)H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Ganapaty S,Srilakshmi GV,Pannakal ST,Rahman H,Laatsch H,Brun Rdoi
10.1016/j.phytochem.2008.10.009subject
Has Abstractpub_date
2009-01-01 00:00:00pages
95-9issue
1eissn
0031-9422issn
1873-3700pii
S0031-9422(08)00480-9journal_volume
70pub_type
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